[1]
Halford GM, Lordkipanidzé M, Watson SP. 50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams. Platelets. 2012:23(6):415-22. doi: 10.3109/09537104.2011.632032. Epub 2011 Nov 18
[PubMed PMID: 22098129]
Level 3 (low-level) evidence
[2]
Konstan MW, VanDevanter DR, Sawicki GS, Pasta DJ, Foreman AJ, Neiman EA, Morgan WJ. Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis. Annals of the American Thoracic Society. 2018 Apr:15(4):485-493. doi: 10.1513/AnnalsATS.201706-486OC. Epub
[PubMed PMID: 29313709]
[3]
Chen Q, Ilanga M, Simbassa SB, Chirra B, Shah KN, Cannon CL. Synergistic Antimicrobial Effects of Ibuprofen Combined with Standard-of-Care Antibiotics against Cystic Fibrosis Pathogens. Biomedicines. 2023 Oct 30:11(11):. doi: 10.3390/biomedicines11112936. Epub 2023 Oct 30
[PubMed PMID: 38001937]
[4]
Mitra S, Weisz D, Jain A, Jong G'. Management of the patent ductus arteriosus in preterm infants. Paediatrics & child health. 2022 Mar:27(1):63-64. doi: 10.1093/pch/pxab085. Epub 2022 Mar 7
[PubMed PMID: 35273674]
[5]
Yeung T, Shahroor M, Jain A, Weisz D, Jasani B. Efficacy and safety of high versus standard dose ibuprofen for patent ductus arteriosus treatment in preterm infants: A systematic review and meta-analysis. Journal of neonatal-perinatal medicine. 2022:15(3):501-510. doi: 10.3233/NPM-210968. Epub
[PubMed PMID: 35404294]
Level 1 (high-level) evidence
[6]
Gummin DD, Mowry JB, Beuhler MC, Spyker DA, Rivers LJ, Feldman R, Brown K, Pham NPT, Bronstein AC, DesLauriers C. 2022 Annual Report of the National Poison Data System(®) (NPDS) from America's Poison Centers(®): 40th Annual Report. Clinical toxicology (Philadelphia, Pa.). 2023 Oct:61(10):717-939. doi: 10.1080/15563650.2023.2268981. Epub 2023 Dec 12
[PubMed PMID: 38084513]
[7]
Apata J, Pennap DD, Mosholder AD. The use of analgesics for intentional self-poisoning: Trends in U.S. poison center data. Journal of psychiatric research. 2023 Jul:163():402-405. doi: 10.1016/j.jpsychires.2023.05.076. Epub 2023 May 27
[PubMed PMID: 37270880]
[8]
Babić Ž, Kordić NB, Rešić A, Turk R. Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children. Arhiv za higijenu rada i toksikologiju. 2021 Dec 30:72(4):299-304. doi: 10.2478/aiht-2021-72-3596. Epub 2021 Dec 30
[PubMed PMID: 34985841]
[9]
Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arteriosclerosis, thrombosis, and vascular biology. 2011 May:31(5):986-1000. doi: 10.1161/ATVBAHA.110.207449. Epub
[PubMed PMID: 21508345]
[10]
Krasniqi V, Dimovski A, Domjanović IK, Bilić I, Božina N. How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity. Arhiv za higijenu rada i toksikologiju. 2016 Mar:67(1):1-8. doi: 10.1515/aiht-2016-67-2754. Epub
[PubMed PMID: 27092633]
Level 2 (mid-level) evidence
[11]
Pilotto A, Seripa D, Franceschi M, Scarcelli C, Colaizzo D, Grandone E, Niro V, Andriulli A, Leandro G, Di Mario F, Dallapiccola B. Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms. Gastroenterology. 2007 Aug:133(2):465-71
[PubMed PMID: 17681167]
Level 3 (low-level) evidence
[12]
Ungprasert P, Cheungpasitporn W, Crowson CS, Matteson EL. Individual non-steroidal anti-inflammatory drugs and risk of acute kidney injury: A systematic review and meta-analysis of observational studies. European journal of internal medicine. 2015 May:26(4):285-91. doi: 10.1016/j.ejim.2015.03.008. Epub 2015 Apr 8
[PubMed PMID: 25862494]
Level 1 (high-level) evidence
[13]
Ferguson MC, Schumann R, Gallagher S, McNicol ED. Single-dose intravenous ibuprofen for acute postoperative pain in adults. The Cochrane database of systematic reviews. 2021 Sep 9:9(9):CD013264. doi: 10.1002/14651858.CD013264.pub2. Epub 2021 Sep 9
[PubMed PMID: 34499349]
Level 1 (high-level) evidence
[14]
Irvine J, Afrose A, Islam N. Formulation and delivery strategies of ibuprofen: challenges and opportunities. Drug development and industrial pharmacy. 2018 Feb:44(2):173-183. doi: 10.1080/03639045.2017.1391838. Epub 2017 Oct 30
[PubMed PMID: 29022772]
[15]
Davies NM. Clinical pharmacokinetics of ibuprofen. The first 30 years. Clinical pharmacokinetics. 1998 Feb:34(2):101-54
[PubMed PMID: 9515184]
[16]
Kauffman RE, Nelson MV. Effect of age on ibuprofen pharmacokinetics and antipyretic response. The Journal of pediatrics. 1992 Dec:121(6):969-73
[PubMed PMID: 1447669]
[17]
Section on Clinical Pharmacology and Therapeutics, Committee on Drugs, Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics. 2011 Mar:127(3):580-7. doi: 10.1542/peds.2010-3852. Epub 2011 Feb 28
[PubMed PMID: 21357332]
[18]
Paul IM, Walson PD. Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review. Current medical research and opinion. 2021 Aug:37(8):1363-1375. doi: 10.1080/03007995.2021.1928617. Epub 2021 Jun 4
[PubMed PMID: 33966545]
Level 3 (low-level) evidence
[19]
Antal EJ, Wright CE 3rd, Brown BL, Albert KS, Aman LC, Levin NW. The influence of hemodialysis on the pharmacokinetics of ibuprofen and its major metabolites. Journal of clinical pharmacology. 1986 Mar:26(3):184-90
[PubMed PMID: 3958223]
[20]
Wanwimolruk S, Brooks PM, Birkett DJ. Protein binding of non-steroidal anti-inflammatory drugs in plasma and synovial fluid of arthritic patients. British journal of clinical pharmacology. 1983 Jan:15(1):91-4
[PubMed PMID: 6849750]
[21]
Hall AH, Smolinske SC, Conrad FL, Wruk KM, Kulig KW, Dwelle TL, Rumack BH. Ibuprofen overdose: 126 cases. Annals of emergency medicine. 1986 Nov:15(11):1308-13
[PubMed PMID: 3777588]
Level 3 (low-level) evidence
[22]
Volans G, Monaghan J, Colbridge M. Ibuprofen overdose. International journal of clinical practice. Supplement. 2003 Apr:(135):54-60
[PubMed PMID: 12723749]
[23]
Kimmey MB, Silverstein FE, Saunders DR, Chapman RC. Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine. Digestive diseases and sciences. 1987 Aug:32(8):851-6
[PubMed PMID: 3301232]
[24]
Meijuan Z, Yu P, Yuan J, Yu T, Sun D. Stomach ulcer caused by mistakenly oral medication of 14,400 mg ibuprofen: A case report. Medicine. 2023 May 19:102(20):e33812. doi: 10.1097/MD.0000000000033812. Epub
[PubMed PMID: 37335722]
Level 3 (low-level) evidence
[25]
Marciniak KE, Thomas IH, Brogan TV, Roberts JS, Czaja A, Mazor SS. Massive ibuprofen overdose requiring extracorporeal membrane oxygenation for cardiovascular support. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2007 Mar:8(2):180-2
[PubMed PMID: 17273120]
[26]
Lee CY, Finkler A. Acute intoxication due to ibuprofen overdose. Archives of pathology & laboratory medicine. 1986 Aug:110(8):747-9
[PubMed PMID: 3755329]
[27]
Clarke SF, Arepalli N, Armstrong C, Dargan PI. Duodenal perforation after ibuprofen overdose. Journal of toxicology. Clinical toxicology. 2004:42(7):983-5
[PubMed PMID: 15641644]
[28]
Zoubek ME, Lucena MI, Andrade RJ, Stephens C. Systematic review: ibuprofen-induced liver injury. Alimentary pharmacology & therapeutics. 2020 Mar:51(6):603-611. doi: 10.1111/apt.15645. Epub 2020 Jan 27
[PubMed PMID: 31984540]
Level 1 (high-level) evidence
[29]
Gui MZ, Ni M, Yin XD, Zhang T, Li ZL. Ibuprofen induced Stevens-Johnson syndrome and liver injury in children: a case report. Translational pediatrics. 2021 Jun:10(6):1737-1742. doi: 10.21037/tp-21-8. Epub
[PubMed PMID: 34295789]
Level 3 (low-level) evidence
[30]
Whelton A, Stout RL, Spilman PS, Klassen DK. Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison. Annals of internal medicine. 1990 Apr 15:112(8):568-76
[PubMed PMID: 2183665]
Level 1 (high-level) evidence
[31]
Murray MD, Brater DC. Adverse effects of nonsteroidal anti-inflammatory drugs on renal function. Annals of internal medicine. 1990 Apr 15:112(8):559-60
[PubMed PMID: 2327675]
[32]
Kim J, Gazarian M, Verjee Z, Johnson D. Acute renal insufficiency in ibuprofen overdose. Pediatric emergency care. 1995 Apr:11(2):107-8
[PubMed PMID: 7596869]
[33]
Hall AH, Smolinske SC, Stover B, Conrad FL, Rumack BH. Ibuprofen overdose in adults. Journal of toxicology. Clinical toxicology. 1992:30(1):23-37
[PubMed PMID: 1542147]
[34]
Court H, Volans GN. Poisoning after overdose with non-steroidal anti-inflammatory drugs. Adverse drug reactions and acute poisoning reviews. 1984 Spring:3(1):1-21
[PubMed PMID: 6541425]
[35]
Mattana J, Perinbasekar S, Brod-Miller C. Near-fatal but reversible acute renal failure after massive ibuprofen ingestion. The American journal of the medical sciences. 1997 Feb:313(2):117-9
[PubMed PMID: 9030680]
[36]
McElwee NE, Veltri JC, Bradford DC, Rollins DE. A prospective, population-based study of acute ibuprofen overdose: complications are rare and routine serum levels not warranted. Annals of emergency medicine. 1990 Jun:19(6):657-62
[PubMed PMID: 2188537]
[37]
Chelluri L, Jastremski MS. Coma caused by ibuprofen overdose. Critical care medicine. 1986 Dec:14(12):1078-9
[PubMed PMID: 3780253]
[38]
Oker EE, Hermann L, Baum CR, Fentzke KM, Sigg T, Leikin JB. Serious toxicity in a young child due to ibuprofen. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2000 Jul:7(7):821-3
[PubMed PMID: 10917334]
[39]
Easley RB, Altemeier WA 3rd. Central nervous system manifestations of an ibuprofen overdose reversed by naloxone. Pediatric emergency care. 2000 Feb:16(1):39-41
[PubMed PMID: 10698143]
[40]
Pires SAP, Lemos AP, Pereira EPMN, Maia PADSV, Agro JPSEABD. IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT. Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo. 2019:37(3):382-385. doi: 10.1590/1984-0462/;2019;37;3;00016. Epub 2019 Jun 3
[PubMed PMID: 31166468]
Level 3 (low-level) evidence
[41]
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P. Drug-induced aseptic meningitis: a mini-review. Fundamental & clinical pharmacology. 2018 Jun:32(3):252-260. doi: 10.1111/fcp.12349. Epub 2018 Mar 9
[PubMed PMID: 29364542]
[42]
Holubek W, Stolbach A, Nurok S, Lopez O, Wetter A, Nelson L. A report of two deaths from massive ibuprofen ingestion. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2007 Jun:3(2):52-5
[PubMed PMID: 18072160]
[43]
Zuckerman GB, Uy CC. Shock, metabolic acidosis, and coma following ibuprofen overdose in a child. The Annals of pharmacotherapy. 1995 Sep:29(9):869-71
[PubMed PMID: 8547735]
[44]
Pollack BE, Barbaro RP, Selewski DT, Carlton EF. Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis. Drug and therapeutics bulletin. 2023 Jul:61(7):108-111. doi: 10.1136/dtb.2022.244281.rep. Epub 2023 Jan 17
[PubMed PMID: 36649974]
[45]
Pollack BE, Barbaro RP, Selewski DT, Carlton EF. Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis. BMJ case reports. 2022 Feb 7:15(2):. doi: 10.1136/bcr-2021-244281. Epub 2022 Feb 7
[PubMed PMID: 35131772]
Level 3 (low-level) evidence
[46]
Page CB, Wilson PA, Foy A, Downes MA, Whyte IM, Isbister GK. Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis. The Medical journal of Australia. 2011 Jun 6:194(11):614
[PubMed PMID: 21644884]
[47]
Levine M, Khurana A, Ruha AM. Polyuria, acidosis, and coma following massive ibuprofen ingestion. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2010 Sep:6(3):315-7. doi: 10.1007/s13181-010-0076-8. Epub
[PubMed PMID: 20419362]
[48]
Jain S. Ibuprofen-induced thrombocytopenia. The British journal of clinical practice. 1994 Jan-Feb:48(1):51
[PubMed PMID: 8179987]
[49]
Seifert SA, Bronstein AC, McGuire T. Massive ibuprofen ingestion with survival. Journal of toxicology. Clinical toxicology. 2000:38(1):55-7
[PubMed PMID: 10696926]
[50]
Vayne C, Guéry EA, Rollin J, Baglo T, Petermann R, Gruel Y. Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia. Journal of clinical medicine. 2020 Jul 13:9(7):. doi: 10.3390/jcm9072212. Epub 2020 Jul 13
[PubMed PMID: 32668640]
[51]
Benmoussa J, Chevenon M, Nandi M, Forlenza TJ, Nfonoyim J. Ibuprofen-induced thrombotic thrombocytopenic purpura. The American journal of emergency medicine. 2016 May:34(5):942.e5-7. doi: 10.1016/j.ajem.2015.10.044. Epub 2015 Oct 26
[PubMed PMID: 26643158]
[53]
Catizone L, Santoro A, Scialfa G, Cagnoli L, Fabbri L. [Thrombotic thrombocytopenic purpura due to administration of Ibuprofen]. Minerva nefrologica. 1974 Nov-Dec:21(6):439-44
[PubMed PMID: 4477894]
[54]
Vogts N, Young S. Pulmonary infiltrates with eosinophilia syndrome in ibuprofen overdose. The New Zealand medical journal. 2012 Aug 24:125(1360):74-5
[PubMed PMID: 22932657]
[55]
Lindblad R, Rödjer S. A case of severe pancytopenia caused by ibuprofen. Journal of internal medicine. 1991 Mar:229(3):281-3
[PubMed PMID: 2007846]
Level 3 (low-level) evidence
[56]
Lapatto-Reiniluoto O, Kivistö KT, Neuvonen PJ. Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram. British journal of clinical pharmacology. 1999 Aug:48(2):148-53
[PubMed PMID: 10417490]
[57]
Wood DM, Monaghan J, Streete P, Jones AL, Dargan PI. Fatality after deliberate ingestion of sustained-release ibuprofen: a case report. Critical care (London, England). 2006:10(2):R44
[PubMed PMID: 16542487]
Level 3 (low-level) evidence
[58]
Richy F, Bruyere O, Ethgen O, Rabenda V, Bouvenot G, Audran M, Herrero-Beaumont G, Moore A, Eliakim R, Haim M, Reginster JY. Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Annals of the rheumatic diseases. 2004 Jul:63(7):759-66
[PubMed PMID: 15194568]
Level 3 (low-level) evidence