Chronic Fatigue Syndrome


4.5 out of 5 (63 Reviews)



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Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes

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Activity Description

Chronic fatigue syndrome, also known as myalgic encephalomyelitis, is a complex multisystem disease commonly characterized by severe fatigue, cognitive dysfunction, sleep problems, autonomic dysfunction, and post-exertional malaise, which can severely impair patients' ability to conduct the activities of daily living. Therefore, early diagnosis and prompt treatment are critical to prevent high morbidity and its overwhelming effect on the quality of life. This activity reviews the evaluation and treatment of chronic fatigue syndrome and highlights the interprofessional team's role in evaluating and treating patients with this condition.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, nurse practitioners, and social workers.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the etiology of chronic fatigue syndrome.
  • Review the appropriate evaluation of chronic fatigue syndrome.
  • Outline the management options available for chronic fatigue syndrome.
  • Describe interprofessional team strategies for improving care coordination and communication to ensure the best outcomes for patients with chronic fatigue syndrome.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

As a Jointly Accredited Organization, StatPearls, LLC is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. StatPearls, LLC maintains responsibility for this course. Social workers completing this course receive 1.50 continuing education credits.

Social Workers: StatPearls, LLC designates this continuing education activity for 1.50 ASWB ACE credit(s) for social workers. Social Workers should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

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This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




Thomas P. on 3/5/2021

The presentations was excellent. UGH, the evaluation section was so long, repetitive and tedious. It took almost as long to do that as to read the educational portion. You should have 2 different options, one to satisfy CME’s and one for MOC. This is my first activity after subscribing. I hope that all the evaluations aren’t like this one. I will probably just read the articles and forego the CME’s if they are.

Patricia Lynn O. on 3/21/2021

This CME activity promotes outdated and harmful treatment recommendations for MECFS. They go against CDC guidelines. Providers will cause serious harm to their patients if they use this Cme to update their knowledge. Bad bad bad!!!!! Will no longer be using this CE service!

Maya L. on 4/12/2021

April W. on 11/4/2021

Diane P. on 12/4/2021

I am grateful to read the newer criteria for CFS. That is very helpful .

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muhammad i. on 7/16/2023

Good review of subject

Mark S. on 7/29/2023

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