4.7 out of 5 (373 Reviews)



Post Assessment Questions


Start Date

1 Sep 2023

Last Review Date

21 Apr 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

180 Minutes

Need Help?  If you have a system or content concerns, please contact

Activity Description

Syphilis is a systemic, bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. The infection progresses through 4 stages (primary, secondary, latent, and tertiary) and can affect virtually every organ system in the body, even many years or even decades after the original infection.

Early symptoms include the painless chancre of primary disease or the unique maculopapular rash involving the palms and soles of secondary syphilis. As the clinical manifestations are so varied, clinicians need to be constantly aware of the possibility of syphilis in the differential diagnosis of a multitude of illnesses affecting any bodily organ system and perform screening serologic testing frequently and appropriately, particularly in high-risk populations. Fortunately, the causative organism remains very sensitive to antibiotics, and benzathine penicillin G is still recommended for most stages of syphilis, although IV aqueous penicillin G is preferred for neurosyphilis. 

This course will provide clinicians with a comprehensive understanding of syphilis, including its epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and management strategies. Participants will gain insights into the complexities of syphilis management, together with its medical, psychosocial, and public health implications. This activity also highlights the role of the interprofessional team in addressing the evolving landscape of syphilis and promoting the health and well-being of individuals and populations.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, nurse practitioners, and dentists.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Differentiate the stages of syphilis adn the likelihood of progression over time.

  • Apply best practice guidelines in the diagnosis of syphilis based on practices outlined by public health organizations.

  • Improve the diagnosis and treatment of syphilis through increased education of healthcare professionals about the varied clinical manifestations of syphilis.

  • Collaborate among interprofessional team members and public health officials to improve outcomes for patients affected by syphilis.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 3.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website,, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 3.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Otolaryngology–Head and Neck Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn their required annual part II self-assessment credit in the American Board of Otolaryngology–Head and Neck Surgery’s Continuing Certification program (formerly known as MOC). It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of recognizing participation.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 3.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 3.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact


This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




Susana C. on 4/27/2021

Katherine N. on 9/2/2021

Nogba P. on 9/29/2021

John L. on 10/5/2021

MIA G. on 10/14/2021

John M. on 10/21/2021

Terri C. on 12/23/2021

Adele L. on 12/29/2021

Laurie K. on 1/1/2022

Amelia G. on 1/16/2022

Tiffany N. on 1/25/2022

Timothy M. on 2/16/2022

Kathleen H. on 3/5/2022

Maria B. on 3/6/2022

Kentaro I. on 4/9/2022

Stacy G. on 4/27/2022

Alyssa B. on 5/7/2022

Dr.Mallikarjun K. on 5/8/2022

Rebecca T. on 6/8/2022

Thanks much

Dr. Mallikarjuna S. on 6/11/2022

Adriana S. on 9/8/2022

Leon C. on 10/11/2022

Jennifer D. on 11/8/2022

The information was well explained.

Jessica Z. on 12/3/2022

Douglas M. on 12/2/2022

Muammar A. on 12/8/2022

Jacqueline W. on 12/13/2022

Nathalie G. on 12/17/2022

Ingerlisa M. on 12/25/2022

Ramon M. on 1/2/2023

More CE for this offering

Peter S. on 1/9/2023

Nicole S. on 2/20/2023

Skyler S. on 1/26/2023

JOSE P. on 2/1/2023

Jill P. on 2/8/2023

Timothy A. on 2/19/2023

Questions were way too many and complex.

Ron H. on 3/20/2023

Shantu P. on 3/28/2023

Christine G. on 4/6/2023

Louie L. on 4/23/2023

Sherie O. on 4/24/2023

Alice H. on 5/2/2023

Urvil P. on 5/3/2023

Gary T. on 5/4/2023

Aaron M. on 5/7/2023

John h. on 5/5/2023

hussien b. on 5/6/2023

James O. on 5/14/2023

shayna m. on 5/26/2023

Nogba P. on 5/26/2023

randal h. on 5/31/2023

Peter M. on 6/5/2023

James N. on 6/5/2023

William H. on 6/5/2023

Krista B. on 6/13/2023

MELISSA B. on 6/15/2023

Gregory P. on 6/15/2023

Stephanie D. on 6/17/2023

Sheila C. on 6/17/2023

Gurinder S. on 6/22/2023

Amina O. on 6/30/2023

Kevin M. on 7/2/2023

Jihye J. on 7/4/2023

kevin n. on 7/7/2023

SHOHALA N. on 7/10/2023

Taha D. on 7/11/2023

Megan B. on 7/11/2023

Jennifer H. on 7/13/2023

Michele N. on 7/16/2023

Peter W. on 7/21/2023

Morgan C. on 7/23/2023

Michael B. on 7/24/2023

Catherine O. on 7/27/2023

Nikotah C. on 7/27/2023

Katherine L. on 7/27/2023

shelley h. on 7/29/2023

Alyssa S. on 7/31/2023

Keon M. on 8/4/2023

Anna A. on 8/20/2023

Elise C. on 8/12/2023

Allen A. on 8/12/2023

Tayebeh N. on 8/21/2023

Joshua K. on 8/21/2023

Sendil K. on 8/22/2023

Raja A. on 8/22/2023

Gabrielle P. on 8/22/2023

Katy K. on 8/24/2023

Richard H. on 8/27/2023

Ryan M. on 9/1/2023

Sikander A. on 9/6/2023

Christina K. on 9/7/2023

Chris C. on 9/12/2023

Camille C. on 9/12/2023

Adrian J. on 9/20/2023

Linden G. on 9/21/2023

CHAULA P. on 9/25/2023

Nicole F. on 9/25/2023

Peter L. on 9/27/2023

Christine F. on 9/30/2023

Hormoz F. on 9/30/2023

Jeff P. on 9/30/2023

Marcelo on 10/4/2023

hiba e. on 10/5/2023

Renea o. on 10/10/2023

Julu W. on 10/10/2023

Advaith B. on 10/11/2023

Brandi H. on 10/12/2023

Jeffrey L. on 10/14/2023

Laura R. on 10/14/2023

Lisa P. on 10/15/2023

Paul S. on 10/18/2023

Shengen Y. on 10/19/2023

Mackenzie H. on 10/19/2023

Faith M. on 10/20/2023

Tanveer H. on 11/20/2023

Robert K. on 10/21/2023

Kimberly K. on 10/22/2023

Sandra R. on 10/22/2023

Mark G. on 10/23/2023

Ogheneyerovwo D. on 10/24/2023

Corey E. on 10/25/2023

Christa R. on 10/26/2023

Snehit P. on 10/26/2023

Puja P. on 10/27/2023

Shearin H. on 10/27/2023

Ali I. on 10/30/2023

Daniel T. on 10/30/2023

Claire I. on 10/30/2023

Sarah H. on 11/3/2023

NO A. on 11/5/2023

maria j. on 11/5/2023

chelsea t. on 11/9/2023

Maria W. on 11/10/2023

John H. on 11/15/2023

Thanh N. on 11/16/2023

ChihTao H. on 11/17/2023

Peter D. on 11/19/2023

Jeffrey S. on 11/20/2023

Matthew E. on 11/21/2023

rachel j. on 11/21/2023

Penny S. on 11/23/2023

Larry M. on 11/23/2023

maryam m. on 11/24/2023

William J. on 11/26/2023

Roseann J. on 11/28/2023

Sharon V. on 11/29/2023

Catherine B. on 12/1/2023

GARY T. on 12/1/2023

James W. on 12/2/2023


Daniel A. on 12/3/2023

DENA A. on 12/3/2023

Ephrem P. on 12/4/2023

william c. on 12/5/2023

Claudia C. on 12/6/2023

Abigail S. on 12/6/2023

Jennifer S. on 12/6/2023

Colbert P. on 12/6/2023

Susan N. on 12/6/2023

makondo s. on 12/12/2023

Kevin M. on 12/13/2023

Elsa V. on 12/14/2023

Jessica H. on 12/26/2023


Natasha B. on 12/15/2023

Joahd T. on 12/16/2023

Jeffrey M. on 12/17/2023

Graham H. on 12/17/2023

Javita R. on 12/18/2023


Marti E. on 12/18/2023

Stephen M. on 12/18/2023

Mike B. on 12/19/2023

Puneet s. on 12/19/2023

Samantha B. on 12/20/2023

GREGORY C. on 12/20/2023

Michi C. on 12/21/2023

Mona K. on 12/25/2023

Jason R. on 12/21/2023

Suzanne M. on 12/22/2023

sadia a. on 12/23/2023

Excellent CME

Nawaz S. on 12/23/2023

vasudha d. on 12/23/2023

valerie b. on 12/25/2023

Donald R. on 12/25/2023

Aeyrie R. on 12/25/2023

paul n. on 12/25/2023

syed nasir h. on 12/26/2023

Jessaka F. on 12/25/2023

Jordan C. on 12/26/2023

Jonathan B. on 12/27/2023

Aurelio T. on 12/27/2023

Rashmi M. on 12/28/2023

Osama Q. on 12/28/2023

Thank you!

Emily E. on 12/28/2023

Karim E. on 12/28/2023

Jennifer G. on 12/29/2023

James B. on 12/29/2023

Honey C. on 12/30/2023

ARVIND B. on 12/29/2023

Pankaj L. on 12/30/2023

Antonio V. on 12/30/2023

Tawana T. on 12/30/2023

STANLEY K. on 12/30/2023

Cynthia D. on 12/30/2023

mohammed a. on 12/30/2023

Todd G. on 12/30/2023

Ajit R. on 12/30/2023

Janet U. on 12/30/2023

Fernando B. on 12/30/2023

Elena V. on 12/30/2023

Illuri r. on 12/30/2023

RAchel G. on 12/31/2023

Shawn O. on 12/31/2023

James L. on 12/31/2023

Sergio M. on 12/31/2023

zubair s. on 12/31/2023

Nancy A. on 12/31/2023

David C. on 12/31/2023

Linda R. on 12/31/2023

Ashar U. on 12/31/2023

Elias M. on 12/31/2023

Ismaeel A. on 1/7/2024

Robert R. on 1/12/2024

Amber D. on 1/14/2024

Zbigniew C. on 1/14/2024

paul n. on 1/17/2024

Stephanie K. on 1/17/2024

Matthew F. on 1/18/2024

Calvin K. on 1/19/2024

shelley h. on 1/19/2024

David F. on 1/20/2024

Chelsea A. on 1/20/2024

Bruce L. on 1/20/2024

Julie B. on 1/21/2024

Christopher M. on 1/22/2024

Melissa C. on 1/23/2024

Fabian C. on 1/23/2024

Mark G. on 1/26/2024

Morgan M. on 1/27/2024

robert c. on 1/28/2024

laura L. on 1/29/2024

Scott S. on 1/30/2024

Karin A. on 1/30/2024

DANIEL W. on 1/30/2024

Erin R. on 1/30/2024

Jenny K. on 1/31/2024

Erica G. on 1/31/2024

William S. on 1/31/2024

Emily N. on 2/1/2024

David S. on 2/4/2024

Jamar G. on 2/4/2024

Kristina H. on 2/4/2024

Chelsea V. on 2/5/2024

Christin H. on 2/6/2024

brian w. on 2/8/2024

Gardenia Z. on 2/12/2024

ISLAM A. on 2/13/2024

Mazda A. on 2/16/2024

Stacy W. on 2/16/2024

Brittany C. on 2/16/2024

Glenna M. on 2/18/2024

Stacey S. on 2/18/2024

Jon M. on 2/21/2024

Giulio R. on 2/22/2024

jorge h. on 2/22/2024

Christine G. on 2/23/2024

Bozena B. on 2/24/2024

Derek F. on 2/24/2024

Syed B. on 2/27/2024

Klaus M. on 2/29/2024

Yashma P. on 2/29/2024

Eric F. on 2/29/2024

Natasha D. on 2/29/2024

Abdul K. on 3/2/2024

Melissa A. on 3/4/2024

Anne G. on 3/5/2024

Anisha N. on 3/6/2024

Manar A. on 3/7/2024

Thomas S. on 3/8/2024

ahdy b. on 3/8/2024

Helean Z. on 3/9/2024

Greg H. on 3/13/2024

Christopher K. on 3/17/2024

John H. on 3/18/2024

Cheryl M. on 3/20/2024

Hugo N. on 4/9/2024

Alan S. on 3/21/2024

Ashley H. on 3/23/2024

Jerome S. on 3/23/2024

Jennifer w. on 3/23/2024

Robin H. on 3/24/2024

Luis C. on 3/25/2024

Desiree S. on 3/26/2024

Prathibha P. on 3/26/2024

Katie R. on 3/26/2024

Vasco M. on 3/27/2024

Eric H. on 3/27/2024

Kristine G. on 3/28/2024

Kalpesh A. on 3/28/2024

Anand D. on 3/28/2024

Emmeline K. on 4/1/2024

Saima A. on 4/2/2024

Jesse K. on 4/5/2024

Lindsey A. on 4/5/2024

Jayshree D. on 4/8/2024

Rebecca A. on 4/8/2024

Nichole M. on 4/8/2024

Laura C. on 4/9/2024

Matthew J. on 4/11/2024

Andrew R. on 4/11/2024

Tracie P. on 4/13/2024

obrien m. on 4/13/2024

Eric P. on 4/14/2024

Robert S. on 4/15/2024

Nancy A. on 4/16/2024

David W. on 4/17/2024

jemini i. on 4/17/2024

Poorvi C. on 4/22/2024

Andrew B. on 4/23/2024

Armen N. on 4/24/2024

Alexandra U. on 4/25/2024

Rosario L. on 4/27/2024

Louise L. on 4/27/2024

Charles j. on 4/27/2024

Cassandra C. on 4/29/2024

Tiffany M. on 4/29/2024

Ryan G. on 5/1/2024

Richard M. on 5/1/2024

John C. on 5/5/2024

Jessica K. on 5/6/2024

kevin n. on 5/7/2024

Lea D. on 5/7/2024

Amber S. on 5/10/2024

Joseph G. on 5/10/2024

daniel p. on 5/11/2024

Megan W. on 5/12/2024

Jingbo L. on 5/14/2024

Patrick C. on 5/16/2024

Azzam A. on 5/17/2024

Kirsten B. on 5/18/2024

Darius J. on 5/18/2024

Neil K. on 5/18/2024

Jerin M. on 5/19/2024

Maria V. on 5/20/2024

Clare G. on 5/24/2024

Jacqueline R. on 5/26/2024

Manoj P. on 5/27/2024

Baylee E. on 5/28/2024

Rachel B. on 5/28/2024

Revathi K. on 5/30/2024

Aneesh M. on 5/31/2024

ERIK S. on 6/1/2024

CHAD I. on 6/1/2024

JASON K. on 6/1/2024

Charles S. on 6/2/2024

Madison C. on 6/2/2024

BRANDI B. on 6/4/2024

jeffrey m. on 6/5/2024

Chris H. on 6/7/2024

tammy a. on 6/10/2024

Corey T. on 6/11/2024

Ellen J. on 6/13/2024

Michael O. on 6/13/2024

May G. on 6/14/2024

CHAULA P. on 6/14/2024

John F. on 6/16/2024

Christopher B. on 6/17/2024

Amanda K. on 6/18/2024

Kevin C. on 6/18/2024

Rahul A. on 6/18/2024

Isabel S. on 6/21/2024

JOSE T. on 6/19/2024

Renae R. on 6/19/2024

Lauren C. on 6/20/2024

April P. on 6/21/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6671 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7921.5 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$147 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$399 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$599 per 1 year per user