4.5 out of 5 (124 Reviews)



Post Assessment Questions


Start Date

1 Sep 2023

Last Review Date

30 Jan 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes

Need Help?  If you have a system or content concerns, please contact

Activity Description

Ketamine hydrochloride, commonly known as ketamine, is a medication approved by the United States Food and Drug Administration (FDA) for use as a general anesthetic either on its own or in combination with other medications. The medication is highly effective for brief medical procedures that do not necessitate skeletal muscle relaxation and can be utilized as a pre-anesthetic for the induction of general anesthesia when combined with other general anesthetic agents. Furthermore, ketamine is FDA-approved for enhancing the effects of low-potency substances such as nitrous oxide.

In addition to its anesthetic applications, ketamine proves invaluable in pain management, addressing treatment-resistant depression, managing suicidal ideation, and treating refractory status epilepticus, with specific indications awaiting FDA approval. The dosage determines the application and resulting effects of the drug, leading to variations in the prescribing protocol. This versatility renders ketamine valuable in both anesthesia and pain management. Ongoing research explores the potential applications of ketamine in psychiatry across all isomeric forms. At elevated doses, ketamine operates primarily as a sedative rather than an analgesic agent. This activity reviews ketamine's indications, mechanism of action, pharmacokinetics, adverse drug reactions, monitoring strategies, drug-drug interactions, and clinical toxicology for healthcare professionals to facilitate the enhancement of clinical best practice guidelines.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify appropriate indications for ketamine use, recognizing its role in general anesthesia, pain management, and potential applications in psychiatry.

  • Screen patients thoroughly, assessing their medical history and contraindications to determine suitability for ketamine administration.

  • Assess patients' responses to ketamine, adapting dosages and treatment plans based on individual needs and clinical outcomes.

  • Collaborate with interdisciplinary teams, sharing expertise on ketamine's diverse applications and contributing to comprehensive patient care plans.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website,, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact


This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




Valerie H. on 6/5/2021

Linda R. on 9/10/2021

Jennifer J. on 2/25/2022

Ashley M. on 7/15/2022

Nicole F. on 8/29/2022

Nicholas D. on 9/27/2022

April D. on 9/10/2022

Terri C. on 3/7/2022

Eli N. on 10/4/2022

Joel L. on 1/12/2022

Janet P. on 12/13/2021

Mark O. on 11/24/2022

Elizabeth T. on 11/8/2021

lee a. on 9/26/2021

ROBERT G. on 9/6/2021

Lisa T. on 12/30/2022

Darra H. on 12/31/2022

Kristyn T. on 9/2/2021

Brandon P. on 1/9/2023

Thiago C. on 8/22/2021

Carolyn S. on 1/22/2023

raymond a. on 7/18/2021

Julie J. on 4/10/2021

Ryan P. on 7/14/2022

Lindsay W. on 4/27/2022

SANTHA A. on 3/28/2022

Victoria C. on 3/5/2022

Laura B. on 1/24/2022

ROBERT G. on 10/17/2022

Nicole Q. on 12/5/2022

Crista B. on 11/4/2021

Carrie H. on 10/3/2022

Nicole G. on 9/17/2022

Nicole S. on 10/13/2022

Bernadette G. on 9/9/2022

Judith B. on 8/29/2022

Mindy K. on 8/24/2022

Richard D. on 5/7/2023

Mary Y. on 5/17/2023

Cherie S. on 8/4/2022

Amy V. on 5/31/2023

Anne D. on 6/7/2023

Marti W. on 7/11/2022

Susan A. on 10/12/2022

Jessica K. on 12/26/2022

Jennifer K. on 4/30/2023

John M. on 8/19/2023

Jennifer A. on 2/6/2023

Kelsey B. on 2/15/2023

Christina v. on 4/17/2023

Kristin T. on 9/23/2023

Kristina C. on 4/19/2023

Kim B. on 12/31/2022

Christina C. on 1/4/2023

Tami O. on 10/18/2023

MARK M. on 10/19/2023

Megan A. on 10/22/2023

Ginger B. on 1/10/2023

jubril o. on 1/29/2023

Sarah I. on 10/24/2023

Johana R. on 10/25/2023

judy s. on 1/30/2023

Eric S. on 2/18/2023

Jeffrey H. on 2/1/2023

Susan h. on 4/27/2023

Brendalla G. on 9/11/2023

Kim G. on 11/17/2023

coral c. on 5/4/2023

Monica H. on 7/28/2023

Daniel K. on 6/13/2023

Clifford B. on 6/14/2023

Margaret D. on 12/12/2023

Brandi M. on 2/9/2023

Selena R. on 7/2/2023

Sherilyn F. on 7/10/2023

John B. on 4/19/2023

Robin S. on 8/11/2023

Dakota P. on 4/25/2023

Chelsea V. on 1/9/2024

robert s. on 4/28/2023

dana c. on 4/29/2023

Julia D. on 9/17/2023

Kimberly B. on 10/13/2023

Jibril Y. on 2/20/2024

Dipesh B. on 2/24/2024

Narcisa R. on 2/25/2024

Amanda K. on 10/17/2023

James C. on 10/22/2023

Amber W. on 3/14/2024

Cameo J. on 10/23/2023

Jamie H. on 10/29/2023

Laura P. on 3/24/2024

Herman E. on 12/19/2023

James W. on 11/1/2023

Tracy E. on 1/13/2024

paulette w. on 1/21/2024

Cheryl M. on 1/27/2024

Cathryn S. on 4/15/2024

Maja s. on 11/22/2023

Sarah L. on 4/16/2024

Michael A. on 11/24/2023

Sara D. on 11/30/2023

Robert H. on 12/10/2023

Isabel R. on 2/1/2024

Valerie M. on 12/14/2023

Colleen K. on 12/22/2023

Stacy c. on 2/5/2024

Mandy H. on 12/27/2023

Carolyn M. on 12/28/2023

TERRIE G. on 2/25/2024

JOHN M. on 1/11/2024

Brooke R. on 1/3/2024

Ali I. on 3/2/2024

Lisa I. on 2/28/2024

Elizabeth D. on 3/17/2024

Laura M. on 10/29/2023

Justin C. on 2/19/2024

Jamie A. on 3/19/2024

Jennifer B. on 3/29/2024

Jeremy B. on 4/1/2024

Kimberly E. on 4/8/2024

Jessica C. on 4/15/2024

Sara R. on 4/16/2024

Ashley L. on 4/3/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6673 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7923.5 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$73.50 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$399 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$599 per 1 year per user