Cold Knife Conization of the Cervix


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Start Date

1 Sep 2023

Last Review Date

26 Oct 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes

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Activity Description

Cervical conization is an excisional surgical procedure employed to diagnose cervical dysplasia and for therapeutic purposes in some patients. Also known as cone biopsy, this procedure involves the removal of a cone-shaped section of the cervix, encompassing the entire transformation zone and any suspicious cervical lesions. This excised tissue is subsequently subjected to histological analysis. When all cervical dysplastic lesions are contained within the specimen, the procedure serves both diagnostic and therapeutic purposes.

Cervical conization can be conducted using various techniques, such as cold knife cone (CKC), laser conization, and the loop electrosurgical excision procedure (LEEP), which is also referred to as loop excision of the transformation zone (LLETZ).

Typically, diagnostic excisional procedures are performed when a histological evaluation is required, such as in cases of discordance between cervical cytology and biopsy findings, evidence of severe cervical dysplasia, or the inability to visualize the cervical transformation zone fully. LEEP and CKC are the most commonly utilized methods for cervical conization, and studies have shown them to be equally effective in diagnosing and treating cervical dysplasia. Therefore, choosing an excisional modality is usually based on individualized clinical factors.

CKC is performed with a scalpel, typically under general or regional anesthesia, and is conventionally believed to yield a larger specimen with less thermal damage to the margins compared to other excisional methods. This activity for healthcare professionals is designed to enhance their competence in recognizing indications and contraindications for CKC, understanding the risks, benefits, and complications associated with the procedure, and mastering the technique involved. Additionally, it will review the role of the interprofessional team in caring for patients with cervical intraepithelial neoplasia who undergo CKC, ultimately leading to improved patient outcomes.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the indications for the cervical cold knife cone procedure.

  • Identify the steps in the cervical cold knife cone procedure.

  • Assess and identify the common complications of the cervical cold knife cone procedure.

  • Collaborate with interprofessional team members to optimize outcomes for patients requiring a cervical cold knife cone procedure and to communicate the importance of improving care coordination.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact


This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




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