4.7 out of 5 (252 Reviews)



Post Assessment Questions


Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes

Need Help?  If you have a system or content concerns, please contact

Activity Description

Amitriptyline is in the tricyclic antidepressant (TCA) drug classification and acts by blocking the reuptake of both serotonin and norepinephrine neurotransmitters. Amitriptyline is an FDA-approved medication to treat depression in adults. The non-FDA approved indications are anxiety, post-traumatic stress disorder, insomnia, chronic pain (diabetic neuropathy, fibromyalgia), irritable bowel syndrome, interstitial cystitis (bladder pain syndrome), migraine prophylaxis, postherpetic neuralgia, and sialorrhea. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of amitryptiline in the clinical setting related to the essential points needed by members of an interprofessional team managing the care of patients with indications that can benefit from amitriptyline therapy.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify FDA-approved and off-label indications of amitriptyline.
  • Select the appropriate patient who could benefit from therapy with amitriptyline.
  • Assess patients for potential adverse drug reactions of amitriptyline.
  • Coordinate the patient's amitriptyline therapy with the rest of the medication regimen in light of the drug-drug interaction profile of this medication.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website,, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Otolaryngology–Head and Neck Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn their required annual part II self-assessment credit in the American Board of Otolaryngology–Head and Neck Surgery’s Continuing Certification program (formerly known as MOC). It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of recognizing participation.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact


This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




Sharon M. on 7/2/2021

Alana H. on 8/23/2021

Erica O. on 9/11/2021

David G. on 10/4/2021

Patrick G. on 10/24/2021

Kimberly A. on 10/29/2021

April W. on 11/6/2021

Patricia s. on 12/2/2021

Thank you

Douglas T. on 12/5/2021


Okechukwu O. on 12/11/2021

Jeffrey H. on 12/18/2021

Ketan H. on 11/24/2022

Kathleen H. on 2/4/2022

ALAN L. on 2/20/2022

Priscilla B. on 2/24/2022

Miranda H. on 3/13/2022

BURTON L. on 3/14/2022

Sherryl E. on 3/15/2022

Russell R. on 3/17/2022

Ira on 3/20/2022

Julie P. on 3/27/2022

YOUN JU L. on 4/19/2022

Zana L. on 4/13/2022

Stephanie B. on 4/14/2022

Christopher N. on 5/10/2022

Michele D. on 5/1/2022

Samantha B. on 5/6/2022

There is a vast difference in the questions presented.Some of them give a clear and concise presentation. Meds and conditions are listed and we can make a sound decision. Other questions yield very little information and require us to do a lot of assuming when there in fact, could be multiple different causes for a patient's presentation.

Paul H. on 5/8/2022

Jacinta U. on 5/10/2022

Christine D. on 5/11/2022

Kristina G. on 5/14/2022

Megan G. on 5/18/2022

Shelia C. on 5/18/2022

Deanna K. on 5/22/2022

Bridgette H. on 6/11/2022

Dawn E. on 6/16/2022

Mark W. on 6/16/2022

Nathan S. on 6/23/2022

Pamela D. on 6/22/2022

Appreciate the education!

Eddie T. on 7/2/2022

Stephanie C. on 7/3/2022

Ashley M. on 7/15/2022

Charles T. on 7/28/2022

Brittany T. on 8/1/2022

Kari B. on 8/5/2022

Steve R. on 8/6/2022

Wendy S. on 8/10/2022

Harriett M. on 8/28/2022

Miranda C. on 9/5/2022

Michael S. on 9/7/2022

Nicole G. on 9/29/2022

Spencer a. on 9/20/2022

patricia d. on 10/4/2022

Monica K. on 10/8/2022

Daniel C. on 10/11/2022

Bentley A. on 11/26/2022

Joseph B. on 11/29/2022

Heather K. on 12/4/2022

Wilbert W. on 12/17/2022

Kelli M. on 12/20/2022

Laurie C. on 12/28/2022

Simranjit K. on 12/31/2022

Nancy G. on 1/6/2023

Meghan C. on 1/10/2023

Abbey P. on 1/16/2023

Alria D. on 1/17/2023

Andrea D. on 1/22/2023

Latoya R. on 1/23/2023

Michael M. on 1/25/2023

Skyler S. on 1/26/2023

Stephanie C. on 1/29/2023

Lea O. on 1/31/2023

Ravi J. on 2/10/2023

jubril o. on 2/11/2023

thank you

Melissa S. on 2/14/2023

George G. on 2/15/2023

Timothy A. on 2/17/2023

Christina R. on 2/19/2023

Margo G. on 2/27/2023

Stephanie B. on 3/14/2023

Quinn C. on 3/19/2023

Johanna R. on 3/22/2023

Samantha C. on 3/26/2023

Sharon M. on 4/8/2023

Helen M. on 4/10/2023

Steven H. on 4/11/2023

Shirley A. on 4/13/2023

Susan M. on 4/14/2023

Kelcy C. on 4/18/2023

Mary B. on 4/20/2023

coral c. on 4/21/2023

Valerie B. on 4/28/2023

Faiza H. on 5/1/2023

Allyson K. on 5/3/2023

Amanda L. on 5/7/2023

Amy L. on 5/10/2023

was extremely basic would be wise to add at least cyp2D6 considerations when considering metabolism

Michael S. on 5/18/2023

Stacie C. on 6/2/2023

Natasha M. on 7/22/2023

Michael K. on 6/13/2023

Amber S. on 6/13/2023

Christine M. on 6/17/2023

Stephen B. on 6/24/2023

Christy S. on 6/29/2023

Kevin M. on 7/2/2023

Johnny L. on 7/7/2023

Crystal s. on 7/7/2023

muhammad i. on 7/16/2023

Anthony T. on 7/17/2023

Elizabeth P. on 7/19/2023

Cameo J. on 8/11/2023

Christine G. on 8/13/2023

Teri O. on 8/17/2023

John P. on 8/18/2023

Ryan H. on 8/19/2023

Richard K. on 9/3/2023

Michelle G. on 9/9/2023

Kimberly N. on 9/10/2023

Stephanie H. on 9/11/2023

Andrea L. on 9/13/2023

Ali D. on 9/13/2023

Elizabeth C. on 9/16/2023

Blessing O. on 9/21/2023

Clarivel T. on 9/20/2023

Joline T. on 9/24/2023

Janet R. on 9/24/2023

Alannah C. on 9/27/2023

Scott O. on 9/29/2023

Jeff P. on 9/30/2023

Stacy R. on 10/6/2023

ROSEMARY D. on 10/7/2023

Genevieve M. on 10/11/2023

Catherine M. on 10/11/2023

John M. on 10/12/2023

Kimberly B. on 10/13/2023

Angie L. on 10/14/2023

Kristi W. on 10/16/2023

Vu H. on 10/20/2023

robert s. on 10/24/2023

Hannah J. on 10/26/2023

Derik S. on 10/28/2023

Faith M. on 10/29/2023

David c. on 10/30/2023

Kery F. on 11/1/2023

Denise W. on 11/4/2023

Kristopher H. on 11/7/2023

prabhakar r. on 11/22/2023

Kelly P. on 11/27/2023

Nanette M. on 12/1/2023

Ashley S. on 12/5/2023

Mohamed E. on 12/7/2023

AJAY Y. on 12/10/2023

Margaret D. on 12/11/2023

Georgina S. on 12/19/2023

Rachel W. on 12/21/2023

Herman E. on 12/21/2023

Sarah N. on 12/22/2023

Arkam R. on 12/24/2023

Michelle M. on 12/28/2023

Jeffrey H. on 12/27/2023

Stacy c. on 12/27/2023

Scott S. on 12/28/2023

Rachel D. on 1/2/2024

Roger C. on 12/29/2023

Lynzee B. on 12/31/2023

Antonio D. on 12/31/2023

Tracy E. on 1/3/2024

Kritsen Z. on 1/4/2024

Jeffrey H. on 1/9/2024

Wojciech F. on 1/10/2024

Robert R. on 1/10/2024

Emily B. on 1/13/2024

Anne C. on 1/14/2024

Justin C. on 1/17/2024

Britten W. on 1/16/2024

Andres M. on 1/17/2024

Chelsea V. on 1/26/2024

Joanne P. on 1/19/2024

jacob l. on 1/23/2024

Marti E. on 1/23/2024

Joseph S. on 1/26/2024

Ann P. on 2/2/2024

Stacy c. on 2/5/2024

April P. on 2/5/2024

Sharon T. on 2/10/2024

Jibril Y. on 2/18/2024

Truclinh N. on 2/20/2024

Kelly T. on 2/21/2024

john d. on 2/26/2024

Shelagh A. on 2/27/2024

ShuYu K. on 3/3/2024

Drazen P. on 3/4/2024

Karen L. on 3/4/2024

Holly F. on 3/6/2024

Ameena A. on 3/7/2024

Leah M. on 3/9/2024

Helean Z. on 3/9/2024

Danielle K. on 3/15/2024

DYLAN A. on 3/16/2024

Andrew F. on 4/3/2024

jeffrey m. on 3/22/2024

Corry R. on 3/23/2024

Robin H. on 3/24/2024

STEVEN B. on 3/26/2024

Lauren H. on 3/27/2024

Kristine G. on 4/4/2024

Jerry D. on 4/8/2024

Theresa D. on 4/18/2024

thomas d. on 4/15/2024

Sara R. on 4/15/2024

Theresa J. on 4/16/2024

Sarah L. on 4/16/2024

Jennifer V. on 4/19/2024

Anne C. on 4/26/2024

Mindy T. on 4/29/2024

Steve R. on 4/29/2024

Hung N. on 5/9/2024

Renee P. on 5/9/2024

Richard B. on 5/9/2024

Amber S. on 5/9/2024

Christopher V. on 5/26/2024

Stephanie C. on 5/15/2024

Allison M. on 5/17/2024

Morgan b. on 5/18/2024

ian b. on 5/18/2024

Sandra A. on 5/19/2024

Amy P. on 5/19/2024

Elizabeth F. on 5/21/2024

William N. on 5/21/2024

Theresa M. on 5/27/2024

Rex G. on 5/28/2024

ishvar p. on 5/29/2024

Alicia S. on 6/3/2024

Enitan E. on 6/4/2024

Azzam A. on 6/5/2024

on 6/6/2024

CHAD I. on 6/6/2024

Erik S. on 6/6/2024

Travis M. on 6/6/2024

Danielle C. on 6/12/2024

Sarah D. on 6/15/2024

Hilina y. on 6/20/2024

SUSAN L. on 6/29/2024

Jessica M. on 6/30/2024

Jaclyn B. on 7/2/2024

Tania K. on 7/4/2024

Alex R. on 7/6/2024

Ashley F. on 7/9/2024

James F. on 7/10/2024

Lesly P. on 7/12/2024

Andrea S. on 7/16/2024

Jennifer C. on 7/17/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6669 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7919 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$73.50 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$399 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$599 per 1 year per user