4.7 out of 5 (269 Reviews)



Post Assessment Questions


Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes

Need Help?  If you have a system or content concerns, please contact

Activity Description

Allopurinol, a xanthine oxidase inhibitor, is a urate-lowering medication that is FDA approved for managing gout, preventing tumor lysis syndrome, and preventing recurrent calcium nephrolithiasis in patients with hyperuricosuria. Other non-FDA-approved indications include Lesch-Nyhan syndrome-associated hyperuricemia and the prevention of recurrent uric acid nephrolithiasis. It is important to note that asymptomatic hyperuricemia is not an indication of allopurinol or any urate-lowering therapy. This activity outlines the indications, mechanism, pharmacology, contraindications, and adverse events associated with allopurinol drug therapy.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the various indications, both approved and off-label, for allopurinol therapy.
  • Describe the potential adverse effects of allopurinol.
  • Summarize the mechanism of action of allopurinol.
  • Review the importance of coordinating and collaborating among various disciplines in an interprofessional health team to coordinate care and management to enhance outcomes for patients receiving allopurinol therapy.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact


This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




Deborah Z. on 2/23/2021

Trang T. on 5/2/2021

edwina w. on 8/22/2021

Erica O. on 9/11/2021

Hurline S. on 10/5/2021

Lisa R. on 10/28/2021

McKenzie H. on 11/4/2021

patricia h. on 11/29/2021

David Y. on 11/21/2021

Alicia T. on 12/12/2021

Gerri S. on 12/21/2021

Therese M. on 12/28/2021

Janice on 1/15/2022

sean l. on 1/21/2022

Sherryl E. on 2/4/2022

devin n. on 2/26/2022

Frederick a. on 2/27/2022

Robin A. on 3/21/2022

Michael M. on 3/24/2022

Julie P. on 3/31/2022

YOUN JU L. on 4/19/2022

Tiffany M. on 4/24/2022

Michele D. on 5/1/2022

i enjoyed it

Angjelin S. on 5/3/2022

Paul H. on 5/6/2022

Scott S. on 5/10/2022

Jacinta U. on 5/10/2022

Christine D. on 5/11/2022

Mike B. on 5/17/2022

Shelia C. on 5/18/2022

Deanna K. on 5/22/2022

Kimberly G. on 6/21/2022

Nancy F. on 6/21/2022

Dawn E. on 6/28/2022

Grace N. on 6/27/2022

Jennifer L. on 7/4/2022

Marti W. on 7/11/2022

Brittany T. on 8/1/2022

Good refresher. Thank you.

Kelly A. on 8/4/2022

Tiffany R. on 8/12/2022

yvette t. on 8/14/2022

Natalia M. on 8/21/2022

victoria s. on 8/23/2022

Clifford A. on 8/28/2022

Nicole F. on 8/28/2022

Holly E. on 9/6/2022

Natalie F. on 9/12/2022

Joy R. on 9/16/2022

Nicole G. on 9/23/2022

IRIS O. on 9/24/2022

Toni-Marie P. on 10/1/2022

Tamatha J. on 10/4/2022

Nicole S. on 10/4/2022

Christy E. on 10/10/2022

Matthew S. on 10/24/2022

Theodore B. on 11/3/2022

Rayne R. on 11/9/2022

jeffrey t. on 11/15/2022

Amber A. on 11/20/2022

long h. on 12/15/2022

Renato P. on 12/22/2022

efstathia c. on 12/26/2022

Nextgen l. on 12/27/2022

Rachael F. on 12/27/2022

on 12/28/2022

Simranjit K. on 12/30/2022

Jennifer S. on 1/2/2023

Darra H. on 1/7/2023

Vanessa S. on 1/10/2023

Stephanie S. on 1/10/2023

Abrah N. on 1/13/2023

MARGARONE M. on 1/16/2023

Stephanie F. on 1/19/2023

Austin S. on 1/20/2023

Li s. on 1/24/2023

Stephanie C. on 1/26/2023

Lisa B. on 1/29/2023

May G. on 1/31/2023

jubril o. on 2/7/2023

Dominika S. on 2/8/2023

Jayma C. on 2/13/2023

amy s. on 2/16/2023

Timothy A. on 2/17/2023

Rose F. on 2/28/2023

Johanna R. on 3/20/2023

krista g. on 3/22/2023

Tammy S. on 3/28/2023

Rebecca S. on 3/29/2023

John C. on 4/2/2023

Jennifer P. on 4/15/2023

Kinga V. on 4/16/2023

Naga Dharshan D. on 4/20/2023

Valerie B. on 4/28/2023

Kim L. on 5/3/2023

Amy L. on 5/7/2023

Mary M. on 5/22/2023

DENISE S. on 6/1/2023

Jana T. on 6/1/2023

Kimberley R. on 6/5/2023

Daniel K. on 6/7/2023

Amber S. on 6/13/2023

Mikala R. on 6/16/2023

John H. on 6/24/2023

Brianna L. on 6/25/2023

Stephanie K. on 6/26/2023

Corazon B. on 6/26/2023

Alina G. on 7/28/2023

Christy S. on 6/29/2023

Kevin M. on 7/2/2023

Keisha D. on 7/10/2023

Maria C. on 7/17/2023

Matthew P. on 7/21/2023

Amy G. on 8/1/2023

Mergene T. on 8/5/2023

Whittney H. on 8/9/2023

Britten W. on 8/30/2023

Sallie V. on 8/15/2023

Sara R. on 8/15/2023

Erik l. on 8/16/2023

Janet B. on 8/17/2023

Vera F. on 8/22/2023

Blessing O. on 8/22/2023

Aaren M. on 8/25/2023

Alison S. on 8/25/2023

Kelly K. on 8/26/2023

Lily L. on 8/27/2023

Mary Y. on 8/30/2023

Peter S. on 8/30/2023

Allynda H. on 9/3/2023

Lauren E. on 9/6/2023

Renea o. on 9/7/2023

Michelle G. on 9/9/2023

Andrea L. on 9/12/2023

Ritza G. on 9/13/2023

Taylor B. on 9/14/2023

barbara h. on 9/15/2023

Elizabeth C. on 9/16/2023

Haleigh K. on 9/16/2023

Ryan H. on 9/17/2023

Jeff P. on 9/18/2023

Carla J. on 9/20/2023

Samantha P. on 9/21/2023

Lyonschvala n. on 9/24/2023

Alannah C. on 9/26/2023

Stephanie R. on 9/26/2023

Monique A. on 9/29/2023

Genevieve M. on 10/1/2023

Lauren S. on 10/2/2023

Stacy R. on 10/5/2023

Theresa M. on 10/5/2023

Karen L. on 10/16/2023

Mackenzie H. on 10/19/2023

Allyson M. on 10/20/2023

Sandra R. on 10/22/2023

Gary W. on 10/23/2023

Kristopher H. on 10/24/2023

Sarah B. on 10/26/2023

Jamin S. on 10/27/2023

LAURA P. on 10/28/2023

Faith M. on 10/29/2023

Daniel T. on 10/29/2023

Shivan K. on 10/30/2023

Paul D. on 10/30/2023

Ronald A. on 10/31/2023

Stephen W. on 11/1/2023

SUSAN L. on 11/2/2023

NO A. on 11/5/2023

Sydney w. on 11/5/2023

sarah s. on 11/7/2023

Meagan R. on 11/8/2023

ISLAM A. on 11/11/2023

William S. on 11/12/2023

Andrew L. on 11/15/2023

channa p. on 11/15/2023

Brian M. on 11/17/2023

prabhakar r. on 11/21/2023

Chih-Tao H. on 11/22/2023

Katrina B. on 11/24/2023

Elisabeth I. on 11/30/2023

Therese M. on 12/4/2023

Bridget H. on 12/4/2023

Drew H. on 12/5/2023

Bruno V. on 12/12/2023

ANTOINETTE L. on 12/8/2023

Jessica N. on 12/9/2023

Kaman C. on 12/10/2023

Antonio H. on 12/10/2023

Sadie H. on 12/13/2023

Andrew f. on 12/17/2023

Wassim E. on 12/17/2023

William H. on 12/23/2023

Cristovao V. on 12/23/2023

valerie b. on 12/24/2023

Antonio D. on 12/24/2023

Michelle M. on 12/25/2023

sandhya s. on 12/25/2023

Caitlin B. on 12/26/2023

nduka-obi o. on 12/27/2023

Douglas W. on 12/27/2023

Bruce T. on 12/28/2023

Kathleen . on 12/29/2023

Linda R. on 12/30/2023

Erika G. on 12/31/2023

thank you

Opeyemi B. on 1/1/2024

Anne G. on 1/2/2024

BRANDI B. on 1/5/2024

Vu H. on 1/9/2024

Astrid S. on 1/9/2024

Robert d. on 1/10/2024

Chelsea V. on 1/11/2024

Julie A. on 1/13/2024

Linda B. on 1/15/2024

great article

Nadiya K. on 1/16/2024

Britten W. on 1/16/2024

Erika G. on 1/16/2024

Laura B. on 1/17/2024

thomas h. on 1/19/2024

Michael F. on 1/22/2024

BLAKE W. on 1/23/2024

Deborah P. on 1/22/2024

Scott S. on 1/22/2024

Natasha N. on 1/28/2024

laura L. on 1/29/2024

Lori M. on 1/29/2024


Mohamad K. on 1/30/2024

Bernadette A. on 1/30/2024

Monique A. on 2/1/2024

Karolina P. on 2/2/2024

Therese M. on 2/3/2024

Helean Z. on 2/4/2024

Brittany C. on 2/6/2024

Lauren S. on 2/7/2024

anne F. on 2/7/2024

Kela L. on 2/8/2024

THAN A. on 2/9/2024

Jenny K. on 2/12/2024

Mary Y. on 2/15/2024

Mark H. on 2/18/2024

Wassim E. on 2/19/2024

Kristoffer K. on 2/20/2024

Puneet T. on 2/21/2024

Kelly T. on 2/21/2024

Nicole T. on 2/23/2024

Redentor R. on 2/27/2024

Shu-Yu K. on 3/3/2024

THERESA M. on 3/4/2024

Benjamin S. on 3/5/2024

Derrick R. on 3/7/2024

Jacob S. on 3/7/2024

Ariel V. on 3/9/2024

Ameena a. on 3/10/2024

Zhengyi C. on 3/10/2024

Elizabeth D. on 3/17/2024

Laura C. on 3/17/2024

Robin H. on 3/23/2024

Lauren H. on 3/27/2024

Kristine G. on 3/29/2024

Iesha M. on 3/31/2024

Ann C. on 3/31/2024

michael a. on 4/4/2024

Jerry D. on 4/7/2024

Melissa C. on 4/8/2024

cyrus i. on 4/11/2024

Eskinder A. on 4/12/2024

Mark G. on 4/13/2024

Tracie P. on 4/13/2024

Evelyn C. on 4/14/2024

Julie F. on 4/17/2024

Ralf T. on 4/18/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6673 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7923.5 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$73.50 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$399 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$599 per 1 year per user