Ehlers-Danlos Syndrome


4.8 out of 5 (151 Reviews)



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Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

90 Minutes

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Activity Description

Ehlers-Danlos syndrome (EDS) is a genetic disorder affecting collagen formation and function. It affects virtually every organ system, which can result in significant morbidity and mortality. Complications of this disease include arterial rupture, organ rupture, joint dislocation, chronic pain, and fatigue, among many others. Proper diagnosis of EDS is essential to improving the overall health and well-being of affected patients as well as mitigating these complications. This activity outlines the background, presentation, evaluation, and management of Ehlers-Danlos syndrome and its complications. It further highlights the role of an interprofessional team in ensuring the best patient outcomes.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Review the diagnostic approaches and the importance of proper identification of this condition.
  • Describe the various differential diagnoses for Ehlers-Danlos syndrome.
  • Summarize the multitude of disease complications of Ehlers Danlos syndrome.
  • Outline the importance of an interprofessional and collaborative approach to the care of patients with Ehlers-Danlos syndrome (EDS) to improve overall patient well-being and satisfaction in the face of this chronic disease.


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COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Internal Medicine
  • Adolescent Medicine
  • Internal Medicine
  • Rheumatology
American Board of Pathology
  • Molecular Genetic Pathology
  • Soft Tissue & Bone
American Board of Pediatrics
  • Adolescent Medicine
  • General Pediatrics
  • Pediatric Rheumatology

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

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  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


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    Misty J. on 5/30/2022

    I highly appreciate the testing strategy offered by stat pearls. Clinical application is a much better indicator of learning than regurgitation of information read.

    Reni M. on 5/30/2022

    Excellent presentation!

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    Ashley B. on 6/2/2022

    The topics are very interesting and put stress over the clinical aspects .

    Dung N. on 6/8/2022

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    Qendresa B. on 6/4/2022

    Very informative and interesting information

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    FELICE B. on 6/14/2022

    This was a difficult topic - very happy I reviewed it. With the 3M coding updates it appears as a possible diagnosis associated with many disease conditions.

    Dawn B. on 6/14/2022

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    Very impressed by the depth of the topics covered and the number of topics available.

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    Andres G. on 6/30/2022

    Thank you

    Mohammed M. on 6/30/2022

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    Julie C. on 6/30/2022

    Great module!

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    Prabhat K. on 7/10/2022

    None. The team do the work very well.

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