3,4-Methylenedioxy-Methamphetamine Toxicity


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Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

90 Minutes

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Activity Description

This activity reviews the FDA-class 1 drug 3,4 - methylenedioxymethamphetamine, also known as MDMA, ecstasy, or molly. The drug is known to promote a sense of euphoria and facilitate empathy and communication. Unfortunately, it can have dangerous effects on the cardiovascular, neurologic, renal, and hepatic systems and can lead to devastating consequences, including death. This activity reviews the potential for 3,4 -methylenedioxymethamphetamine toxicity, treatment approaches to patients who have overdosed on it, and the role of the interprofessional care team in improving outcomes for patients that use 3,4 -methylenedioxymethamphetamine.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the signs and symptoms that a patient with 3,4 -methylenedioxymethamphetamine toxicity might exhibit.
  • Outline the treatment strategy for a patient with 3,4 -methylenedioxymethamphetamine toxicity.
  • Identify rapid sequence intubation agents that should be avoided if a patient with 3,4 -methylenedioxymethamphetamine toxicity presents in a hyper-adrenergic state or if rhabdomyolysis is a consideration.
  • Explain why 3,4 -methylenedioxymethamphetamine toxicity requires an interprofessional team approach.


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This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

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This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Anesthesiology
  • Critical Care Medicine
American Board of Internal Medicine
  • Critical Care Medicine
  • Internal Medicine
American Board of Pathology
  • Chemical Pathology
  • Forensic Pathology
American Board of Pediatrics
  • Medical Toxicology

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    The activity is instructive and it can be informative for the general population

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    Excellent when combined with other toxicity eg., TCA

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