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Alpha Receptor Agonist Toxicity |
Credits: 1.00 Post-Assessment Questions: 4
Release Date: 5 Oct 2020
Expiration Date: 15 Aug 2021
Last Reviewed: 15 Aug 2020
Estimated Time To Finish: 60 Minutes
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Alpha-adrenergic agonist toxicity is due to a broad group of pharmaceutical agents known as alpha agonists, which can be further broken down into central alpha-2 agonists and peripheral alpha-1 agonists. Stimulation of central alpha-2 receptors causes decreased secretion of catecholamines through a negative feedback mechanism. Stimulation of peripheral alpha-1 receptors primarily increases blood pressure via induced vasoconstriction. Alpha-adrenergic agonist toxicity is of primary concern with alpha-2 adrenergic agonist xenobiotics through the resulting depletion of catecholamines associated with these agents; however, there are many topical alpha-1 agonists that when misused cause similar toxicity. This activity illustrates the pathophysiology and typical presentation of alpha-adrenergic agonist toxicity and discusses the role of the interprofessional team in evaluating and managing the condition to achieve better clinical outcomes.
This activity has been designed to meet the educational needs of physicians.
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Authors: Kenneth Norman
Editors: Thomas Nappe
Editors-In-Chief: Alan HeffnerSusan MurinChristian Sandrock
Chief Medical Reviewer: B. Zane Horowitz
Nurse Planner/Reviewer/Editor: Lisa Haddad
Nurse Planner/Reviewer/Editor: Bernadette Makar
Nurse Planner/Reviewer/Editor: Dorothy Caputo
Pharmacy Planner/Reviewer/Editor: Mark Pellegrini
Physician Planner/Reviewer/Editor: Scott Dulebohn
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Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
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