Amegakaryocytic Thrombocytopenia

Overview

4.1 out of 5 (8 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Jan 2021

Last Review Date

1 May 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Amegakaryocytic thrombocytopenia is a severe form of thrombocytopenia characterized by diminished or absent megakaryocytes in the bone marrow without other abnormalities. This condition manifests in both congenital and acquired forms. Congenital amegakaryocytic thrombocytopenia manifests with severe thrombocytopenia and bleeding issues at birth, often progressing to bone marrow failure, whereas acquired amegakaryocytic thrombocytopenia typically emerges later in life and may be linked to immune-mediated mechanisms.

Diagnosis involves bone marrow biopsy and genetic testing. Clinicians diagnose congenital amegakaryocytic thrombocytopenia by assessing characteristic bone marrow features and confirming variations in the c-MPL gene. At the same time, diagnosing acquired amegakaryocytic thrombocytopenia relies on clinical suspicion and bone marrow examination showing reduced or absent megakaryocytes.

Treatment approaches differ between the 2 forms. Allogeneic hematopoietic stem cell transplant is the sole curative option for the congenital form associated with a c-MPL mutation. At the same time, treating the acquired form involves addressing the underlying cause, often in conjunction with immunosuppressive medications or bone marrow transplantation. Management requires a comprehensive, multidisciplinary approach tailored to individual patient needs, focusing on bleeding manifestations and preventing progression to bone marrow failure. This topic discusses the etiology, pathophysiology, evaluation, and management of amegakaryocytic thrombocytopenia, providing healthcare professionals with the necessary knowledge to reduce overall morbidity and mortality associated with amegakaryocytic thrombocytopenia.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Differentiate between congenital and acquired forms of amegakaryocytic thrombocytopenia based on clinical presentation and diagnostic criteria.

  • Implement appropriate diagnostic tests, including bone marrow biopsy and genetic testing, for suspected cases of amegakaryocytic thrombocytopenia.

  • Apply evidence-based treatment strategies, including allogeneic hematopoietic stem cell transplant and immunosuppressive therapy, to manage amegakaryocytic thrombocytopenia.

  • Collaborate with hematology clinicians, geneticists, and other healthcare professionals to ensure comprehensive care for patients with amegakaryocytic thrombocytopenia.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Elizabeth E. on 6/20/2022

NISHA N. on 11/17/2022

Dr Sruthi G. on 8/3/2023

Swaminathan I. on 8/22/2023

Richard C. on 10/10/2023

louis v. on 11/3/2023

Tamara H. on 1/23/2024

douglas t. on 3/13/2024

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