Memantine

Overview

4.6 out of 5 (8 Reviews)

Credits

1.00

Post Assessment Questions

6

Start Date

1 Jan 2021

Last Review Date

31 Jan 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Memantine acts as an antagonist for the N-methyl-D-aspartate (NMDA) receptor subtype of the glutamate receptor. Memantine slows the neurotoxicity involved in Alzheimer disease and other neurodegenerative diseases. Memantine is an uncompetitive, low-affinity, open-channel blocker that blocks the extrasynaptic NMDA receptor (NMDAR) that selectively enters the receptor-associated ion channel during its open state. As a result, the drug prevents the disruption of normal synaptic transmission, safeguarding against further damage caused by excitotoxicity-induced neuronal cell death. This is why memantine is commonly used in combination with acetylcholinesterase inhibitors for the treatment of Alzheimer dementia, which is approved by the United States Food and Drug Administration (FDA).

Memantine blocks the NMDAR subtype of glutamate receptors, preventing the overactivation of glutamine receptors and facilitating normal activity. The drug's antagonistic effects counteract an excessively active glutaminergic system in the central nervous system, believed to contribute to the neurotoxicity observed in Alzheimer disease. This activity reviews the pharmacology, indications, adverse effects, drug interactions, and contraindications of memantine, highlighting the collaborative efforts of interprofessional healthcare teams in treating patients with dementia.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify appropriate candidates for memantine therapy based on the diagnosis of moderate to severe Alzheimer dementia and in accordance with FDA-approved indications.

  • Screen patients for contraindications and potential risks associated with memantine, considering factors such as comorbidities and medication interactions.

  • Select suitable combinations of memantine with acetylcholinesterase inhibitors, recognizing the synergistic effects in the treatment of Alzheimer dementia.

  • Coordinate with the interprofessional healthcare team to develop and implement a holistic care plan, considering both pharmacological and non-pharmacological approaches to Alzheimer management.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Mike B. on 3/25/2022

Mary Y. on 3/27/2022

Shirley A. on 4/13/2023

Mary Y. on 5/19/2023

Daniel S. on 10/9/2023

Nancy B. on 12/31/2023

alex b. on 1/21/2024

would like to see NNT for benefit. How to stop or de-prescribe if ineffective.

Nellyda A. on 4/18/2024

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