Acute Transplantation Rejection

Overview

4.8 out of 5 (75 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Jan 2021

Last Review Date

1 May 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Acute transplant rejection is a condition that occurs within a transplant recipient days to months after transplantation, secondary to the recipient's immune system identifying the grafted organ as foreign and mounting a defense. The etiology, pathophysiology, presentation, and management of this commonly occurring transplantation complication are complex. The diagnosis of acute rejection is based on clinical features involving the grafted organ and is confirmed by diagnostic laboratory studies, including tissue biopsy. Treatment primarily involves immunosuppressive medications to induce tolerance of alloreactive donor cells and avert rejection. Early diagnosis and intervention of acute transplantation rejection are critical to prevent the loss of donor organs and tissues. The limitations of current risk prediction algorithms and biomarkers have paved the way for understanding the implications of DNA methylation changes in immune pathways, enabling clinicians to tailor personalized prevention and treatment strategies in solid organ transplantation. 

This activity for healthcare professionals aims to enhance learners' competence in selecting appropriate diagnostic tests, identifying acute rejection promptly, enabling timely intervention to preserve graft function, minimizing systemic immunosuppression-related adverse effects, and emphasizing the crucial role of the interprofessional team in providing holistic care to affected patients.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the clinical features of acute transplant rejection.

  • Select appropriate confirmatory diagnostic studies for acute transplant rejection.

  • Compare treatment options for patients with acute transplant rejection.

  • Apply interprofessional team strategies to improve care coordination and outcomes in patients with acute transplant rejection.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

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