Pneumococcal conjugate vaccine (PCV13) is recommended differently depending on patient population. In patients 6 weeks old through 6 years of age, PCV13 is recommended for active immunization for the prevention of diseases considered invasive and caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. It is also recommended for the prevention and active immunization of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F. In patients aged 7 to 17 years old, it is recommended for prevention of invasive disease in subtypes mentioned above. In patients 18 years old and older, it is indicated for active immunization, and prevention of pneumococcal pneumonia, caused by the subtypes of S. pneumoniae, as listed above.
Another pneumococcal vaccine, PPSV23, is indicated in the United States for all adults 65 years of age and older, as well as younger patients with conditions that increase the risk for developing pneumococcal pneumonia or invasive pneumococcal disease. Conditions in which PPSV23 would be indicated in patients younger than 65 years of age are as follows: chronic heart disease excluding hypertension, chronic lung disease including asthma, diabetes mellitus, cerebrospinal fluid leak, cochlear implant, alcoholism, chronic liver disease, cigarette smoking, hemoglobinopathy (including sickle cell disease), congenital/acquired asplenia, congenital/acquired immunodeficiency, human immunodeficiency virus infection, chronic renal failure, nephrotic syndrome, leukemia, lymphoma, Hodgkin disease, generalized malignancy, patients receiving immunosuppressive medications (anti-tumor necrosis factor [TNF], chemotherapy agents), solid organ transplant, and multiple myeloma. It is also recommended that all patients who received PPSV23 before the age of 65 years be revaccinated at age 65 unless the vaccine is given less than 10 years prior to patient turning 65 years old, in which case patients should be revaccinated 10 years following the first dose. It is also recommended that patients with functional or anatomic asplenia or immunocompromised individuals receive repeat doses of the vaccination every 10 years after the first dose.
PCV13 and PPSV23 Together
While both vaccine types are proven to stimulate long-lasting antibodies in immunocompromised adults, conjugate vaccines have been proven to provide some additional benefits. Benefits of polysaccharide conjugate vaccine over traditional polysaccharide vaccine include that conjugate vaccines stimulate the production of these antibodies in infants and toddlers, as opposed to only healthy adults, as seen with polysaccharide vaccines. Conjugate vaccines have also been found to stimulate mucosal immunity, which decreases colonization, as well as have been proven to provide herd immunity and prime the patient immunologically, for an enhanced host response, unlike traditionally polysaccharide vaccines.
The ACIP recommends that both vaccinations be given to patients with any of the following: Cerebrospinal fluid leak, cochlear implant, anatomic/functional asplenia, and immunocompromising conditions listed above.
Both vaccines promote active immunization against the serotypes of the conjugate and capsular polysaccharides contained in the formulation of the vaccine. Immunity develops approximately 2 to 3 weeks after vaccination and lasts for 5 years. In children and elderly, re-immunization may be needed sooner.
PCV 13 actively immunizes against invasive disease caused by S. pneumoniae capsular serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. All of the serotypes are individually conjugated to a CRM197 protein.
PPSV 23 contains 23 capsular polysaccharides types of S. pneumoniae that represent at least 85% to 90% of pneumococcal disease isolates in the United States. It has shown a 50% to 80% efficacy in preventing invasive pneumococcal disease in adults.
S. pneumoniae serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F
Single 0.5 ml injection, intramuscularly only. In patients 6 weeks through 5 years of age, it is administered as part of a 4-dose immunization series, administered as 0.5 mg intramuscular injections given at 2, 4, 6, and 12 to 15 months of age. In all patients six years of age and older, it is administered at a single 0.5 ml intramuscular injection.
Single 0.5 ml injection, intramuscular/subcutaneously
PCV13 and PPSV23 Together
Patients of any age for whom it is recommended receive both vaccinations and should receive them as follows:
If the patient has had no prior vaccination with either vaccine, the patient should receive a single dose of PCV13. Eight weeks or more following this dose, PPSV23 should be given. PPSV23 should be given no sooner than 8 weeks following administration of PVC13.
If the patient has received PPSV23 in the past, a single dose of PCV13 should be given 1 year after the administration of PPSV23. PVC13 should be given no sooner than 1 year following that administration of PPSV23.
The following adverse effects have been reported in different age groups. The list includes the most common side effects. However, it is not limited to all of the side effects.
Infants and Toddlers (most commonly reported reactions greater than 5%)
Children Aged 5 to 17 Years Old
Adults 18 Years and Older
Common Reactions to PPSV23 (greater than 10% of patients)
Concomitant administration of PPSV23 and live zoster vaccine showed a reduced immune response to live zoster vaccine. It is recommended that they be administered at least 4 weeks apart.
Studies done on animals have not shown fetal adverse effects or increase risk to the fetus. It is unknown if the vaccine is excreted with breast milk. Caution should be exercised when administering this vaccine to breastfeeding women.
Animal reproduction studies have not been conducted. However, PPSV 23 is an inactivated vaccine, and studies of other inactivated vaccines have not shown to cause increased risk to the fetus. It is unknown if the vaccine is excreted with breast milk. Caution should be exercised when administering this vaccine to breastfeeding women.
PCV13 and PPSV23 contraindications include severe allergic or anaphylactic reaction to any component of the formulation of the vaccine or any diphtheria toxoid-containing vaccine. Pregnancy is not a contraindication to vaccination. Pregnant women at high risk of infection are recommended to receive vaccination.
For the first 15 minutes after administration, patients should be monitored for an allergic reaction like anaphylaxis and syncope.
There is no overdose risk with the administration of the vaccine.
The pneumococcal vaccine is effective and can help reduce the risk of infection. The primary care provider, nurse practitioner, pharmacist and other healthcare workers should educate patients on the benefits of the pneumococcal vaccine. Over the years, the vaccine has proven to be safe and effective.
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