Anatomy, Abdomen and Pelvis, Splanchnic Nerves

Article Author:
Alaa Sharabi
Article Editor:
Forshing Lui
Updated:
8/14/2020 10:04:08 PM
PubMed Link:
Anatomy, Abdomen and Pelvis, Splanchnic Nerves

Introduction

The abdomen and the pelvis contain several essential organs. However, it includes a vital network of nerves, as well. The autonomic nervous system control these organs, for which it includes two parts: the sympathetic part and parasympathetic part of the autonomic nervous system. These nerves emanate from the splanchnic nerves and cranial nerve X, which also called the vagus nerve. The first part consists of abdominopelvic splanchnic nerves, prevertebral sympathetic ganglia, and abdominal aortic plexus. While, the parasympathetic portion consists of anterior and posterior vagal trunks, abdominal autonomic nerves plexuses, pelvic splanchnic nerves, and intrinsic parasympathetic ganglia. The focus of this article is on the abdominopelvic and pelvic splanchnic nerves.[1]

The splanchnic nerves are paired autonomic nerves that supply the abdominal and pelvic viscera. They are composed of motor nerve fibers passing to the internal organs, which also called visceral efferent fibers and the sensory nerve fibers that originate from these organs, which also named visceral afferent fibers.[2] On each side, there is a thoracic, lumbar, sacral, and pelvic splanchnic nerve. All these nerves carry presynaptic sympathetic fibers apart from the pelvic splanchnic nerves, which carry preganglionic parasympathetic fibers.[3]  

Structure and Function

The abdominopelvic splanchnic nerves, which form the sympathetic aspect, consists of three branches. The first is the lower thoracic splanchnic nerves that contain greater, lesser, and least branches, which originate from the thoracic division of the sympathetic trunks, and the second one is the lumbar splanchnic nerves that arise from the lumbar division of the sympathetic trunks. The third one is the sacral splanchnic nerves. In comparison, the parasympathetic part consists of the pelvic splanchnic nerves.

The Lower Thoracic Splanchnic Nerves:

Structure:

These nerves are long, and they divide into the greater, lesser, least splanchnic nerves. The greater splanchnic nerves hold branches from T5-T9 thoracic sympathetic ganglia, while the lesser splanchnic nerves emerge from T10-T11 thoracic sympathetic ganglia. The least splanchnic nerve arises from branches of T12.[4][5] All three splanchnic nerves pass through the diaphragm and then diverge and travel to their destination. The greater and lesser splanchnic nerves synapse at the celiac ganglion while the least splanchnic nerve ends by synapsing within the renal ganglion.[6]

The greater splanchnic nerve passes through the diaphragm by aortic hiatus and ends in the superior preaortic ganglia. The postsynaptic fibers then run toward the organs of the foregut, which is the celiac plexus.[4] While the lesser splanchnic nerves are inferolateral to the greater splanchnic nerve. It synapses with the aortic renal ganglia and the superior mesenteric ganglia.[5]

Function

The greater splanchnic nerve plays a significant role in the inhibitory effects of the foregut. It leads to inhibition of the secretions and motility of the distal esophagus, stomach, and duodenum. Additionally, the greater splanchnic nerve causes inhibition of the bile emptying beside the inhibition of the contraction of the gallbladder smooth muscle, which leads to inhibits the pancreas to secrete their enzymes that stimulate glucagon release which leads to the inhibition of the insulin release. Also, this nerve plays a role in the stimulation of glycogenolysis, gluconeogenesis, and glucose release. Eventually, this nerve innervates the capsule of the spleen, which is responsible for splenic pain.[4]

The Lumbar Splanchnic Nerve:

Structure:

This nerve also consists of paired nerves on each side of the human body that originates from the sympathetic branches of the L1 and L2 nerve roots.[7][5] These nerves reach the aortic plexus and synapse in the accompanying ganglia. The postganglionic fibers innervate blood vessels in the same region as well as glands and smooth muscle.[7]

Function:

The postganglionic sympathetic fibers vasoconstrict blood vessels, innervate and cause secretions from sweat glands, and contraction of the arrector pili muscles. The never fibers that supply the blood vessels of skeletal muscle cause vasodilatation. Eventually, the fibers that reach the viscera regulate glandular secretions, allow for general vasoconstriction, and inhibit smooth muscle contraction of the gastrointestinal system.[7]

The postganglionic sympathetic fibers control the secretions from the sweat glands also give motor to arrector pili muscle by vasoconstrictor blood vessels, while the fibers that enter the skeletal muscle provide motor nerves by vasodilators.[7]

The Sacral Splanchnic Nerve:

Structure:

The sacral splanchnic nerves are paired nerves that run on each side of the human body. These two parallel nerves form the inferior hypogastric plexus to join with the sacral part of the sympathetic trunk.[8] These branches of the splanchnic nerves run up from the inferior hypogastric plexus toward the superior hypogastric plexus and then passing to the inferior mesenteric plexus and the aortic plexus to innervate the hindgut.[8]

Function:

The sacral splanchnic nerve gives both sensory and motor to the posterior aspect of the leg, foot, and the muscle and the skin of the pelvis. The main branches of this splanchnic nerve join and form parts of the superior, inferior gluteal, posterior cutaneous, sciatic, and finally, the pudendal nerves.[8]  

The Pelvic Splanchnic Nerves: 

Structure:

The PSNs join the inferior hypogastric plexus (IHP) at the lower medial edge of the coccygeus muscle.[9] Nerve bundles from S2, S3, and S4 spinal roots converge to form from 2 to 4 bilateral larger nerve bundles of the PSN. Each bundle contains 3,500 to 6,000 individual nerve fibers dispersed evenly in surrounding loose connective tissue.[11][12] 

Function:

These nerves are responsible for the parasympathetic activity and nociception of the bladder, left colon, sigmoid colon, and rectum, and are at risk during any radical pelvic surgery.[10]

Embryology

During the fifth week of the development of the embryo, the neural crest cells form, and the cells migrate on both sides in the thoracic region of the spinal cord, creating paired cell masses which is dorsolateral to the aorta that called ganglia. All these sympathetic ganglia are joined in a bilateral chain by longitudinal nerve fibers, which are called sympathetic trunks along each side of the vertebral bodies. 

Plenty of neural crest cells relocate ventrally to the aorta to create neurons in the preaortic ganglia, such as the celiac and mesenteric ganglia. Some sympathetic axons migrate to a paravertebral ganglion when they can synapse with neurons; also they may descend or ascend at other points to synapse in the trunk. While other presynaptic fibers run without synapsing through the paravertebral ganglia, forming the viscera's splanchnic nerves to innervate the viscera.[8]

Nerves

The Lower Thoracic Splanchnic Nerve:

  • The greater splanchnic nerve:
    • This nerve originates from the sympathetic trunk from level T5-T9. Also, it provides both afferent and efferent fibers.[4]
  • The lesser splanchnic nerve:
    • This nerve arises from the T10-T11 level.
  • The least splanchnic nerve:
    • This nerve arises from the T12 level.

Lumbar Splanchnic Nerve:

The lumbar splanchnic nerve originates from the abdominal portion of the sympathetic trunk. Medially, this nerve gives off 3 or 4 lumbar splanchnic nerves, for which it travels to the superior hypogastric plexuses (SHP), intermesenteric, and inferior mesenteric plexuses.[7]

Pelvic Splanchnic Nerve:

The splanchnic nerves branches give sympathetic and parasympathetic innervation to the pelvis. The sympathetic innervation arises from the level of  T12 to L2. The parasympathetic innervation originates from the S2 to S4 level, which is also called the pelvic splanchnic nerve.[9]

Muscles

The Lower Thoracic Splanchnic Nerve:

This nerve plays a role in pain perception in cases of pancreatic cancer and chronic pancreatitis. The greater splanchnic nerve assists with the motility of the foregut; it also provides the adrenal medulla by the sympathetic innervation. Additionally, it supplies the alimentary canal, gallbladder, liver,  pancreas, spleen, and the adrenal medulla.[4]

Lumbar Splanchnic Nerve:

This nerve provides sympathetic innervation to the smooth muscles of the pelvic viscera and hindgut. Mainly, it targets the kidneys and the large intestine.[7]

Sacral Splanchnic Nerve:

The sacral splanchnic nerve gives both sensory and motor innervation to the back of the thigh, part of the pelvis, and most of the lower legs and feet. 

Pelvic Splanchnic Nerve:

The pelvic viscera controlled parasympathetically via the pelvic splanchnic nerves, which then merges with inferior hypogastric vessels (IHV) and gives branches that contribute innervation to the fundus of the bladder, spermatic cord and ductus deferens. Also, it provides branches into the prostatic plexus for which it supplies the corpora cavernosa, the prostate, and urethra. However, in females, this nerve gives branches to supply the clitoris, the wall of the vagina, and the erectile tissue of the vestibule.[10]

Surgical Considerations

Splanchnicectomy is the procedure that used mostly for the control of unmanageable visceral pain, such as the pain associated with pancreatic cancer. Therefore, understanding of the anatomy of the splanchnic nerves and their variations is very mandatory for the proper performance of this procedure.

Clinical Significance

The splanchnic nerve divides into various sections. These divisions can prove helpful during treatments and procedures for different aspects. For instance, when treating chronic upper abdominal pain, clinicians can target the greater thoracic splanchnic nerves. During surgery, evidence has shown that clinicians can manage the pain by targeting the greater thoracic splanchnic nerves if the patient's complaints are from pancreatitis or pancreatic cancer.

In patients who suffer from flank pain on the left side, pain control is attainable by transecting the left greater thoracic splanchnic nerves. Because bowel movement is under the control of multiple branches, there is a possibility to lose bowel control at any iatrogenic error during the procedure of transection of these nerves.[4]



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References

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[5] Yang HJ,Gil YC,Lee WJ,Kim TJ,Lee HY, Anatomy of thoracic splanchnic nerves for surgical resection. Clinical anatomy (New York, N.Y.). 2008 Mar;     [PubMed PMID: 18288763]
[6] Candal R,Reddy V,Samra NS, Anatomy, Abdomen and Pelvis, Celiac Ganglia 2020 Jan;     [PubMed PMID: 30844156]
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[9] Spence KT,Forro SD, Anatomy, Bony Pelvis and Lower Limb, Nerves 2020 Jan;     [PubMed PMID: 30335337]
[10] McEvoy A,Tetrokalashvili M, Anatomy, Abdomen and Pelvis, Female Pelvic Cavity 2020 Jan;     [PubMed PMID: 30860705]