Subacute Bacterial Endocarditis Prophylaxis


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Start Date

1 Sep 2023

Last Review Date

10 Feb 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes

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Activity Description

Infective endocarditis is an infection of the heart's endocardial surfaces involving one or more heart valves. The incidence of infective endocarditis hospitalization rate is estimated at 12.7 per 100,000 annually in the United States. Most patients (57.7%) affected by this condition were male, and over one-third were aged 70 or older. Several risk factors can predispose patients to infective endocarditis, including structural heart disease (such as valvular disease or congenital heart disease), prosthetic heart valves, indwelling cardiovascular device, intravascular catheter, chronic hemodialysis, HIV infection, diabetes, or a prior history of infective endocarditis.

Infective endocarditis can manifest as either acute or subacute infection. Acute infections are characterized by rapid progression, marked by high fevers, rigors, and sepsis. Conversely, the diagnosis of subacute bacterial endocarditis is often delayed and is characterized by nonspecific symptoms such as weight loss, fatigue, and dyspnea over a period of weeks to months. Clear distinctions exist between subacute and acute bacterial endocarditis. Penicillin-sensitive Streptococcus viridans is the predominant cause of most cases of subacute bacterial endocarditis, whereas Staphylococcus aureus is responsible for the majority of acute bacterial endocarditis cases. Managing both types of bacteria necessitates distinct prophylactic approaches to prevent further complications of infective endocarditis. This activity reviews the prophylaxis of subacute infective endocarditis and highlights the crucial role of the interprofessional healthcare team in managing this condition.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, nurse practitioners, and dentists.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify patients at risk for subacute bacterial endocarditis based on clinical history, underlying cardiac conditions, and predisposing factors.

  • Implement appropriate antibiotic prophylaxis strategies in accordance with current guidelines and evidence-based recommendations for subacute bacterial endocarditis.

  • Select optimal antibiotic regimens for prophylaxis based on patient-specific factors, including allergies, comorbidities, and procedural risks, for treating subacute bacterial endocarditis.

  • Collaborate with interprofessional team members, including cardiologists and infectious disease specialists, to ensure comprehensive management of patients at risk for subacute bacterial endocarditis.


StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

StatPearls, LLC is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Concerns or complaints about a CE provider may be directed to the Commission of Continuing Provider Recognition at

Dentists: StatPearls, LLC designates this continuing education activity for 1.50 ADA credit(s). Dentists should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

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This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.




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