[1]
Badejo OA, Shokunbi MT, Adeolu AA, Oderinde IO, Akinmoladun JA, Ogbole GI. Atypical Variants of Spinal Dysraphism: A Case Series. Journal of the West African College of Surgeons. 2025 Jan-Mar:15(1):118-126. doi: 10.4103/jwas.jwas_186_23. Epub 2024 Aug 2
[PubMed PMID: 39735810]
Level 2 (mid-level) evidence
[2]
Okon II, Temitope AE, Ogundele IO, Akpan U, Mbong EO, Kasimieh O, Chaurasia B, James E, Gbadebo E, Precious FK, Jader A, Okesanya OJ, Karmani V, Erhayanmen M, Lucero-Prisno Iii DE. The current state of Spina Bifida in low- and middle-income countries: where does Africa stand? Neuro-Chirurgie. 2025 Jan:71(1):101616. doi: 10.1016/j.neuchi.2024.101616. Epub 2024 Nov 6
[PubMed PMID: 39515639]
[3]
Parajuli YG, Sinclair M. Cognitive, Behavioral and Educational Outcomes in Children Aged 5-11 Years With Spina Bifida in Northern Ireland. Birth defects research. 2025 Jan:117(1):e2434. doi: 10.1002/bdr2.2434. Epub
[PubMed PMID: 39825676]
[4]
Copp AJ, Adzick NS, Chitty LS, Fletcher JM, Holmbeck GN, Shaw GM. Spina bifida. Nature reviews. Disease primers. 2015 Apr 30:1():15007. doi: 10.1038/nrdp.2015.7. Epub 2015 Apr 30
[PubMed PMID: 27189655]
[5]
Wolujewicz P, Aguiar-Pulido V, Thareja G, Suhre K, Elemento O, Finnell RH, Ross ME. Integrative computational analyses implicate regulatory genomic elements contributing to spina bifida. Genetics in medicine open. 2024:2():101894. doi: 10.1016/j.gimo.2024.101894. Epub 2024 Sep 14
[PubMed PMID: 39669613]
[6]
Aydin S, Jenkins A, Detchou D, Barrie U. Folate fortification for spina bifida: preventing neural tube defects. Neurosurgical review. 2024 Oct 4:47(1):724. doi: 10.1007/s10143-024-02959-z. Epub 2024 Oct 4
[PubMed PMID: 39365348]
[7]
Goel P, Sharma M, Kaushik H, Kumar S, Singh H, Jain V, Dhua AK, Yadav DK, Kumar N, Agarwala S. Genetic Markers of Spina Bifida in an Indian Cohort. Journal of Indian Association of Pediatric Surgeons. 2024 Sep-Oct:29(5):529-535. doi: 10.4103/jiaps.jiaps_64_24. Epub 2024 Sep 9
[PubMed PMID: 39479418]
[8]
Williams J, Mai CT, Mulinare J, Isenburg J, Flood TJ, Ethen M, Frohnert B, Kirby RS, Centers for Disease Control and Prevention. Updated estimates of neural tube defects prevented by mandatory folic Acid fortification - United States, 1995-2011. MMWR. Morbidity and mortality weekly report. 2015 Jan 16:64(1):1-5
[PubMed PMID: 25590678]
[9]
Abdelmageed S, Votoupal M, Lam SK, Garcia RM. Epidemiology and morbidity of spina bifida in Hispanic Americans: a systematic review. BMJ public health. 2024 Jun:2(1):e000746. doi: 10.1136/bmjph-2023-000746. Epub 2024 Jun 22
[PubMed PMID: 40018258]
Level 1 (high-level) evidence
[10]
Feng M, Chen PC, Lin GR, Lin TY, Hsieh TT, Shaw SW. The clinical experience of fetoscopic repair of myelomeningocele in Taiwan: The dilemma in prenatal decision-making and first successful case. Taiwanese journal of obstetrics & gynecology. 2024 Nov:63(6):904-908. doi: 10.1016/j.tjog.2024.07.018. Epub
[PubMed PMID: 39482001]
Level 3 (low-level) evidence
[11]
Schmitt N, Schubert AK, Wulf H, Keil C, Sutton CD, Bedei I, Kalmus G. Initial experience with the anaesthetic management of fetoscopic spina bifida repair at a German University Hospital: A case series of 15 patients. European journal of anaesthesiology and intensive care. 2024 Apr:3(2):e0047. doi: 10.1097/EA9.0000000000000047. Epub 2024 Feb 9
[PubMed PMID: 39917608]
Level 2 (mid-level) evidence
[12]
Canfield MA, Mai CT, Wang Y, O'Halloran A, Marengo LK, Olney RS, Borger CL, Rutkowski R, Fornoff J, Irwin N, Copeland G, Flood TJ, Meyer RE, Rickard R, Alverson CJ, Sweatlock J, Kirby RS, National Birth Defects Prevention Network. The association between race/ethnicity and major birth defects in the United States, 1999-2007. American journal of public health. 2014 Sep:104(9):e14-23. doi: 10.2105/AJPH.2014.302098. Epub 2014 Jul 17
[PubMed PMID: 25033129]
[13]
Trudell AS, Odibo AO. Diagnosis of spina bifida on ultrasound: always termination? Best practice & research. Clinical obstetrics & gynaecology. 2014 Apr:28(3):367-77. doi: 10.1016/j.bpobgyn.2013.10.006. Epub 2013 Dec 3
[PubMed PMID: 24373566]
[14]
Martínez-Lage JF, Moltó MA, Pagán JA. [Latex allergy in patients with spina bifida: prevention and treatment]. Neurocirugia (Asturias, Spain). 2001:12(1):36-42
[PubMed PMID: 11706433]
[15]
Zhu Z, Li H. First-trimester diagnosis of open spina bifida using three-dimensional ultrasound. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2023 Jun:161(3):1095-1097. doi: 10.1002/ijgo.14708. Epub 2023 Feb 15
[PubMed PMID: 36728582]
[16]
Paschereit F, Schindelmann KH, Hummel M, Schneider J, Stoltenburg-Didinger G, Kaindl AM. Cerebral Abnormalities in Spina Bifida: A Neuropathological Study. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2022 Mar-Apr:25(2):107-123. doi: 10.1177/10935266211040500. Epub 2021 Oct 6
[PubMed PMID: 34614376]
[17]
Biggio JR Jr, Owen J, Wenstrom KD, Oakes WJ. Can prenatal ultrasound findings predict ambulatory status in fetuses with open spina bifida? American journal of obstetrics and gynecology. 2001 Nov:185(5):1016-20
[PubMed PMID: 11717624]
[18]
Appasamy M, Roberts D, Pilling D, Buxton N. Antenatal ultrasound and magnetic resonance imaging in localizing the level of lesion in spina bifida and correlation with postnatal outcome. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2006 May:27(5):530-6
[PubMed PMID: 16619377]
[19]
Garg SP, Shah KV, Lentskevich M, Yau A, Gosain AK. Prenatal Spina Bifida Repair: A Survey of Current Practice in the United States. Plastic and reconstructive surgery. Global open. 2024 Dec:12(12):e6377. doi: 10.1097/GOX.0000000000006377. Epub 2024 Dec 19
[PubMed PMID: 39703379]
Level 3 (low-level) evidence
[20]
Zargarzadeh N, Sambatur E, Abiad M, Rojhani E, Javinani A, Northam W, Chmait RH, Krispin E, Aagaard K, Shamshirsaz AA. Gestational age at birth varies by surgical technique in prenatal open spina bifida repair: a systematic review and meta-analysis. American journal of obstetrics and gynecology. 2025 Feb 19:():. pii: S0002-9378(25)00094-8. doi: 10.1016/j.ajog.2025.02.014. Epub 2025 Feb 19
[PubMed PMID: 39983885]
Level 1 (high-level) evidence
[21]
Athiel Y, Cariot L, Jouannic JM, Maillet C, Mauffré V, Adam C, Huet H, Larghero J, Nasone J, Guilbaud L. Safety and efficacy of human umbilical cord-derived mesenchymal stromal cells in fetal ovine myelomeningocele repair. Stem cell research & therapy. 2024 Nov 20:15(1):444. doi: 10.1186/s13287-024-03991-y. Epub 2024 Nov 20
[PubMed PMID: 39568021]
[22]
Kwasnicki A, Stevenson CB, Forde B, Habli M, McKinney D, Goetz E, Lim FY, Peiro JL. Cryopreserved decellularized human umbilical cord matrix allograft as duraplasty for fetoscopic prenatal spina bifida repair. Journal of neurosurgery. Pediatrics. 2025 Feb 1:35(2):149-157. doi: 10.3171/2024.8.PEDS2488. Epub 2024 Nov 8
[PubMed PMID: 39514855]
[23]
Krause M, Leibnitz F, Knüpfer MM, Merkenschlager A, Griessenauer CJ, Gburek-Augustat J. The potential impact of intraoperative neurophysiological monitoring on neurological function outcomes after postnatal spina bifida repair. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2025 Feb 24:41(1):119. doi: 10.1007/s00381-025-06778-5. Epub 2025 Feb 24
[PubMed PMID: 39992435]
[24]
McDevitt WM, Afshari FT, Gallo P, Quinn L, Martin-Lamb D, Pepper J, Lo WB, Rodrigues D, Solanki GA. Intraoperative neuromonitoring and mapping during spinal cord untethering surgery; a single-centre paediatric neurosurgery unit experience. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2024 Nov 30:41(1):20. doi: 10.1007/s00381-024-06665-5. Epub 2024 Nov 30
[PubMed PMID: 39614997]
[25]
Farmer DL, Thom EA, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Gupta N, Adzick NS, Management of Myelomeningocele Study Investigators. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. American journal of obstetrics and gynecology. 2018 Feb:218(2):256.e1-256.e13. doi: 10.1016/j.ajog.2017.12.001. Epub 2017 Dec 12
[PubMed PMID: 29246577]
[26]
Levin-Decanini T, Houtrow A, Katz A. The Evolution of Spina Bifida Treatment Through a Biomedical Ethics Lens. HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues. 2017 Sep:29(3):197-211. doi: 10.1007/s10730-017-9327-2. Epub
[PubMed PMID: 28555303]
[27]
Houtrow AJ, MacPherson C, Jackson-Coty J, Rivera M, Flynn L, Burrows PK, Adzick NS, Fletcher J, Gupta N, Howell LJ, Brock JW 3rd, Lee H, Walker WO, Thom EA. Prenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial. JAMA pediatrics. 2021 Apr 1:175(4):e205674. doi: 10.1001/jamapediatrics.2020.5674. Epub 2021 Apr 5
[PubMed PMID: 33555337]
Level 1 (high-level) evidence
[28]
McKernan G, Mesoros M, Dicianno BE. Machine Learning Algorithms for Prediction of Ambulation and Wheelchair Transfer Ability in Spina Bifida. Archives of physical medicine and rehabilitation. 2025 May:106(5):682-687. doi: 10.1016/j.apmr.2024.11.013. Epub 2024 Dec 2
[PubMed PMID: 39631515]
[29]
Choi EK, Ji Y, Jung E, Bae E. Factors associated with transition readiness among adolescents and young adults with spina bifida in South Korea. Journal of child health care : for professionals working with children in the hospital and community. 2024 Dec 7:():13674935241302438. doi: 10.1177/13674935241302438. Epub 2024 Dec 7
[PubMed PMID: 39644213]
[30]
Naus CA, Mann DG, Andropoulos DB, Belfort MA, Sanz-Cortes M, Whitehead WE, Sutton CD. "This is how we do it" Maternal and fetal anesthetic management for fetoscopic myelomeningocele repairs: the Texas Children's Fetal Center protocol. International journal of obstetric anesthesia. 2025 Feb:61():104316. doi: 10.1016/j.ijoa.2024.104316. Epub 2024 Dec 16
[PubMed PMID: 39721283]
[31]
Keil C, Sass B, Schulze M, Köhler S, Axt-Fliedner R, Bedei I. The Intrauterine Treatment of Open Spinal Dysraphism. Deutsches Arzteblatt international. 2025 Jan 24:122(2):33-37. doi: 10.3238/arztebl.m2024.0239. Epub
[PubMed PMID: 39654393]
[32]
Kulesz PA, Juranek JJ, Fletcher JM, Houtrow AJ, Bilaniuk L, Pruthi S, Glenn OA, MacPherson C. Relations of hippocampal and ventricle volumes to Memory Outcomes in the Management of Myelomeningocele Study (MOMS) prenatal surgery clinical trial. Neuropsychology. 2025 Feb:39(2):162-171. doi: 10.1037/neu0000977. Epub
[PubMed PMID: 39946636]
[33]
Corroenne R, Rangwani S, Whitehead WE, Johnson RM, Nassr AA, Buskmiller C, Munoz JL, Castillo J, Castillo H, Donepudi RV, Belfort MA, Sanz Cortes M. Neurodevelopmental Outcomes after Fetoscopic Myelomeningocele Repair. The Journal of pediatrics. 2025 Apr:279():114472. doi: 10.1016/j.jpeds.2025.114472. Epub 2025 Jan 17
[PubMed PMID: 39828055]
[34]
Showalter VC, Salazar AC, Wilson JM, Ming JM. Pediatric urology patient transition to adulthood: Brief report on the barriers and shortcomings in a resource poor state. Health care transitions. 2024:2():100062. doi: 10.1016/j.hctj.2024.100062. Epub 2024 Jul 9
[PubMed PMID: 39712595]
[35]
Tennant PW, Pearce MS, Bythell M, Rankin J. 20-year survival of children born with congenital anomalies: a population-based study. Lancet (London, England). 2010 Feb 20:375(9715):649-56. doi: 10.1016/S0140-6736(09)61922-X. Epub 2010 Jan 19
[PubMed PMID: 20092884]
[36]
Houtrow AJ, Thom EA, Fletcher JM, Burrows PK, Adzick NS, Thomas NH, Brock JW 3rd, Cooper T, Lee H, Bilaniuk L, Glenn OA, Pruthi S, MacPherson C, Farmer DL, Johnson MP, Howell LJ, Gupta N, Walker WO. Prenatal Repair of Myelomeningocele and School-age Functional Outcomes. Pediatrics. 2020 Feb:145(2):. doi: 10.1542/peds.2019-1544. Epub
[PubMed PMID: 31980545]
[37]
Mannino JE, Reens H, Smith K, Kysh L, Nelson SR, Wang Y, Raam M, Roland M, Speybroeck AV, Betz CL. Psychosocial needs and outcomes of adults with spina bifida: A scoping review, 1974-2023. Health care transitions. 2024:2():100041. doi: 10.1016/j.hctj.2024.100041. Epub 2024 Feb 14
[PubMed PMID: 39712619]
Level 2 (mid-level) evidence
[38]
Yun H, Yang SH, Lee H, Kim SW, Lee YS, Ji Y, Park J, Ji JE, Choi EK. Clinical profile of Korean children with spina bifida: a single-center prospective cohort study. BMC pediatrics. 2024 Dec 3:24(1):791. doi: 10.1186/s12887-024-05229-5. Epub 2024 Dec 3
[PubMed PMID: 39623314]
[39]
Hensel DJ, Young AI, Szymanski KM. Daily Experiences of Urinary and Fecal Incontinence in Young Adults with Spina Bifida: Preliminary Results from an Ecological Momentary Assessment Study. medRxiv : the preprint server for health sciences. 2025 Jan 12:():. pii: 2025.01.10.24313751. doi: 10.1101/2025.01.10.24313751. Epub 2025 Jan 12
[PubMed PMID: 39830248]
Level 2 (mid-level) evidence
[40]
May JM, DeMaio EL, Larson JE. Long-term Clinical and Radiographic Results of Posteromedial Lateral Release for Neuromuscular Clubfoot Deformity. Journal of pediatric orthopedics. 2025 Feb 1:45(2):87-92. doi: 10.1097/BPO.0000000000002848. Epub 2024 Nov 6
[PubMed PMID: 39501684]
[41]
Mariani A, Leclair MD, Faraj S, Péré M, Perrouin-Verbe MA, Loubersac T. Long-term outcomes of "clam" bladder augmentation in a pediatric population with neurogenic refractory bladder dysfunction: A 20-year follow-up experience at single center. The French journal of urology. 2025 Feb 7:35(5):102863. doi: 10.1016/j.fjurol.2025.102863. Epub 2025 Feb 7
[PubMed PMID: 39922313]
[42]
Etter MM, Greuter L, Guzman R, Soleman J, Licci M. Management of a large pseudomeningocele and cerebrospinal fluid fistula after microsurgical resection of recurrent lipomyelomeningocele in children. Neurosurgical focus. 2025 Feb 1:58(2):E17. doi: 10.3171/2024.11.FOCUS24730. Epub
[PubMed PMID: 39891945]
[43]
Franco CL, de Oliveira Júnior JP, Morais BA, Pereira NM, Junior VPP, Germano JRG, de Melo ACT, Ribeiro PRJ. Do routine antibiotics change the myelomeningocele infection rate? A case series. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2025 Jan 28:41(1):95. doi: 10.1007/s00381-024-06748-3. Epub 2025 Jan 28
[PubMed PMID: 39873857]
Level 2 (mid-level) evidence
[44]
Dias LS, Swaroop VT, de Angeli LRA, Larson JE, Rojas AM, Karakostas T. Myelomeningocele: a new functional classification. Journal of children's orthopaedics. 2021 Feb 1:15(1):1-5. doi: 10.1302/1863-2548.15.200248. Epub
[PubMed PMID: 33643452]
[45]
Graham HK, Harvey A, Rodda J, Nattrass GR, Pirpiris M. The Functional Mobility Scale (FMS). Journal of pediatric orthopedics. 2004 Sep-Oct:24(5):514-20
[PubMed PMID: 15308901]
[46]
Swaroop VT, Dias L. Orthopedic management of spina bifida. Part I: hip, knee, and rotational deformities. Journal of children's orthopaedics. 2009 Dec:3(6):441-9. doi: 10.1007/s11832-009-0214-5. Epub 2009 Oct 25
[PubMed PMID: 19856195]
[47]
Betancourt D, Shumate C, Yantz C, Gandhi H, Drummond-Borg M, Kubenka C, Singletary C, Riconda D, Agopian AJ. Self-Reported Access to Specialized Genetics Providers Among Families of Young Children With Birth Defects in Texas. American journal of medical genetics. Part A. 2025 Jun:197(6):e64022. doi: 10.1002/ajmg.a.64022. Epub 2025 Feb 17
[PubMed PMID: 39957499]
[48]
Wald NJ, Vale SH, Bestwick JP, Morris JK. Blood folate level needed for fully effective fortification in the prevention of neural tube defects. Archives of disease in childhood. 2025 Feb 12:():. pii: archdischild-2024-328115. doi: 10.1136/archdischild-2024-328115. Epub 2025 Feb 12
[PubMed PMID: 39939144]
[49]
Lapa DA, Rangwala S, Zebian B, Brown M, Chu J, Chmait RH. Late Prenatal Development of Hindbrain Herniation in Open Spina Bifida. Fetal diagnosis and therapy. 2025 Feb 13:():1-9. doi: 10.1159/000543850. Epub 2025 Feb 13
[PubMed PMID: 39947152]
[50]
Binks JA, Barden WS, Burke TA, Young NL. What do we really know about the transition to adult-centered health care? A focus on cerebral palsy and spina bifida. Archives of physical medicine and rehabilitation. 2007 Aug:88(8):1064-73
[PubMed PMID: 17678671]
[51]
Khan F, Amatya B, Ng L, Galea M. Rehabilitation outcomes in persons with spina bifida: A randomised controlled trial. Journal of rehabilitation medicine. 2015 Sep:47(8):734-40. doi: 10.2340/16501977-1999. Epub
[PubMed PMID: 26181910]
Level 1 (high-level) evidence
[52]
Younsi N, Stein R, Szymanski KM. Adaptation of the German language version of the QUAlity of life assessment of spina bifida for adults (QUALAS-A-G). The journal of spinal cord medicine. 2024 Dec 11:():1-6. doi: 10.1080/10790268.2024.2420141. Epub 2024 Dec 11
[PubMed PMID: 39660977]
Level 2 (mid-level) evidence
[53]
Berihu BA, Mulugeta A, Magana T, Tessema M, Gebreegziabher T, Berhe Y, Welderufael AL, Mekonen HK. Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries. BMC pregnancy and childbirth. 2025 Feb 3:25(1):108. doi: 10.1186/s12884-025-07254-3. Epub 2025 Feb 3
[PubMed PMID: 39901097]
Level 2 (mid-level) evidence
[54]
Arynchyna-Smith A, Arynchyn AN, Kancherla V, Anselmi K, Aban I, Hoogeveen RC, Steffen LM, Becker DJ, Kulczycki A, Carlo WA, Blount JP. Improvement of serum folate status in the US women of reproductive age with fortified iodised salt with folic acid (FISFA study). Public health nutrition. 2024 Oct 24:27(1):e218. doi: 10.1017/S1368980024001903. Epub 2024 Oct 24
[PubMed PMID: 39445493]
[55]
Moodley N, Weidler EM, Ochoa B, Eldredge RS, Rakkar M, Boles K, van Leeuwen K. Satisfaction With Multidisciplinary Team Structure and Function in a Pediatric Outpatient Clinic. Journal of pediatric surgery. 2025 Mar:60(3):162103. doi: 10.1016/j.jpedsurg.2024.162103. Epub 2024 Dec 14
[PubMed PMID: 39733606]
[56]
Dicianno BE. 21st century challenges to the provision of health care to adults with spina bifida: a rehabilitation approach. Archives of physical medicine and rehabilitation. 2014 Sep:95(9):1601-2. doi: 10.1016/j.apmr.2014.01.011. Epub 2014 Jan 29
[PubMed PMID: 24486240]