Epiphrenic Diverticula

Continuing Education Activity

Epiphrenic diverticulum, also known as a pulsion diverticulum, is a rare type of esophageal diverticulum occurring in the distal 10 centimeters of the esophagus, most commonly 4-8 centimeter above the gastric cardia. These rare diverticula are diagnosed with a barium esophagram and can be managed both non-operatively and operatively depending on the patient's symptoms and underlying disorders. This activity reviews the evaluation and management of epiphrenic diverticula and explains the role of the interprofessional team in evaluating and treating patients with this condition.


  • Describe the etiology of epiphrenic diverticula.
  • Describe diagnostic exam findings consistent with epiphrenic diverticula.
  • Outline the management options available for epiphrenic diverticula.


Epiphrenic diverticulum, also known as a pulsion diverticulum, is a rare type of esophageal diverticulum occurring in the distal 10 centimeters (CM) of the esophagus, most commonly 4cm to 8 cm above the gastric cardia.[1] These diverticula are made up of the mucosal and submucosal lining, herniating through a weakness in the muscularis layer of the esophagus, classifying them as false or pseudodiverticula.[2][3] This anatomical weakness in the muscularis layer is where nerves and blood vessels enter to supply the distal esophagus.[4]


An increase in intraluminal esophageal pressure is the etiology of epipherenic diverticula. Although this can be due to several mechanisms, the most common is associated with an underlying esophageal motility disorder. Achalasia, diffuse esophageal spasm, or hypertensive lower esophageal sphincter, which results in a functional obstruction, are some reasons.[4][5][6]

These diverticula can also arise from an iatrogenic cause such as after a fundoplication, which leads to a mechanical obstruction, and increased intraluminal pressure.[5] It is essential to recognize the etiology of epiphrenic diverticula because it will determine the type of treatment necessary to decrease reoccurrence.


Epiphrenic diverticula are a rare type of esophageal diverticula with a prevalence that varies across studies and countries, ranging from 0.015% to 2%. Males show a slightly higher incidence, with a peak age between the sixth and seventh decades of life.[4]

Cancer, specifically squamous cell carcinoma, is associated with epiphrenic diverticula. However, it is a rare event, occurring in about 0.6% of patients. These patients are more likely to be male (83%), have larger diverticula (>5 cm), and have an older age (mean 68 years old).[7]

History and Physical

Patients who develop an epiphrenic diverticulum can present in various situations and with different symptoms, depending on the size of the diverticulum as well as the underlying motility disorder. Those with a small diverticulum and no associated motility disorder may be asymptomatic, and the diverticulum is only discovered incidentally; however, patients with larger diverticulum or those who have a concomitant motility disorder can present with worsening symptoms of dysphagia and regurgitation (the two most common symptoms).

Other symptoms include chest pain, heartburn, nocturnal cough, and asthma. Worrisome symptoms include weight loss, aspiration pneumonia, hematemesis, melena, and odynophagia. They could signify a malignant transformation to esophageal carcinoma. As the diverticulum grows in size, complications can arise. These can be severe heartburn (secondary to stasis) or compression of neighboring structures (esophagus, lung, and heart).[1][6][8][9]


Anatomy of the diverticulum, as well as the commonly associated motility disorders, determine the type and range of diagnostic evaluation needed for epiphrenic diverticulum. It usually consists of barium swallow, esophagogastroduodenoscopy (EGD), and manometry. Esophagogram using barium contrast helps to define the anatomical characteristics of the diverticulum as well as surgical planning. Most commonly, these diverticula are noted on the right side (70%) and are single; however, up to 15% can be multiple.[8] Upper endoscopy helps to visualize the inner lining of the esophagus, evaluating for ulcers, esophagitis, carcinoma, or hiatal hernia. Manometry confirms the presence of a motility disorder. Each of these studies helps to determine the type of surgery to be performed.[4][6]

Treatment / Management

The approach to the treatment of epiphrenic diverticula is based on the underlying motility disorder that is commonly present. Not only must the diverticulum be addressed, usually with a diverticulectomy, but a myotomy, fundoplication, or hiatal hernia repair may also be necessary.

Indications for surgery are not based on size, but instead on symptoms such as worsening dysphagia, regurgitation, food retention; or on complications such as aspiration pneumonia, perforation, and cancer. Asymptomatic patients with epiphrenic diverticulum can be managed non-operatively. The surgical approach can be either open or laparoscopic/robotic with a trend toward minimally invasive due to it's decreased pain, length of stay, and mortality.[2] 

Open approaches can be via laparotomy or left thoracotomy or a combined thoracoabdominal approach. Minimally invasive procedures can be transhiatal or transthoracic depending on the distance of the diverticulum from the lower esophageal sphincter. This also includes robotic-assisted devices such as the Da Vinci Surgical System robot, which may offer better visualization than the traditional laparoscopic/thoracoscopic approach.[9] The use of routine myotomy is commonly employed due to the high association of an underlying motility disorder. Without this procedure, diverticular recurrence rates can approach 20%, with leak rates approaching 24%.[2][4]

The extent of the subdiverticular myotomy is more critical than the proximal length, to encompass the area of obstruction. This is performed between 90-180 degrees from the diverticulectomy site to avoid a leak.[8] A myotomy is usually then followed by a partial fundoplication in order to limit postoperative reflux, which has been noted to occur in 48% of patients versus 9.5% after a Dor fundoplication.[6]

Differential Diagnosis

Epiphrenic diverticula can present in numerous ways, as mentioned earlier. Because of this fact, the differential diagnosis can be vast. Symptoms of dysphagia and regurgitation can be present in other esophageal diverticula, such as Zenker's and traction diverticula. A barium esophagram will help to differentiate these diverticula depending on their anatomical location. These symptoms are also present in many esophageal motility disorders, which may or may not be the underlying cause of the diverticulum. Performing manometric studies will help to determine the type of management. Other differentials to consider are acid reflux, hiatal hernia, benign tumors, and esophageal cancer, all of which can be differentiated based on the standard work-up that includes esophagogram, EGD, and manometry.


Patients with an epiphrenic diverticulum who are asymptomatic are managed with non-operative treatments. These patients develop complications or symptoms <10% of the time [2]. The resolution of symptoms after surgical management in epiphrenic diverticulum approaches 90% in some studies, especially when diverticulectomy is combined with myotomy.[2][10]


Complications of epiphrenic diverticula can arise from both the disease process as well as the treatment process.

Complications can be due to the size of the diverticulum leading to regurgitation, stasis of food, and aspiration. Other complications are due to inflammatory and malignant changes within the diverticulum. These include ulceration, focal adhesions, abscesses, fistulas, bleeding, perforation, and malignant degeneration.[4] These complications are exceedingly rare, but that does not relieve the need for a thorough evaluation before the management of the diverticulum. 

Postoperative complications include esophageal leak, dysphagia, and acid reflux. The risks can be reduced with an understanding of the pathophysiology behind the diverticulum and proper surgical technique. Combining a myotomy with a diverticulectomy minimizes the risk of suture line leak from 35% to 15%.[4] Acid reflux can also be decreased with the addition of a partial fundoplication, especially with underlying achalasia, which has an approximately 50-60% risk of reflux without a myotomy.[8]

Deterrence and Patient Education

In order to effectively manage an epiphrenic diverticulum, patients must be aware of the signs and symptoms associated with the disease process. Not only patients must know them, but they also should understand red flags that may allude to more worrisome pathology such as perforation or malignancy. Asymptomatic patients should relay the presence of the diverticulum to health care workers and be at the lookout for possible symptoms. Blind esophageal intubation should be avoided to help prevent an iatrogenic injury such as perforation of the diverticulum.[1]

Enhancing Healthcare Team Outcomes

Epiphrenic diverticula is a complex disorder that requires input from an interprofessional team of healthcare individuals. Because of its myriad of symptoms, these diverticula can be approached in a medical or surgical direction. Therefore, it requires several specialties, from general practitioners to gastroenterologists to general/thoracic surgeons. Strong communication between specialties can help diagnose patients with epiphrenic diverticulum, as well as to rule out other differentials, or to rule in underlying pathologies (motility disorders).

Treatment strategies center around a thorough workup that includes esophagograms, EGDs, and manometry, but a physicians' clinical perspective is ultimately combining all the data for an accurate diagnosis. The general practitioner can guarantee that epiphrenic diverticula are diagnosed before major complications by coordinating gastroenterology with surgery early on, in the dysphagia workup.

Article Details

Article Author

Bryan Bennett

Article Editor:

Hossein Akhondi


4/7/2021 12:17:35 PM

PubMed Link:

Epiphrenic Diverticula



Abdollahimohammad A,Masinaeinezhad N,Firouzkouhi M, Epiphrenic esophageal diverticula. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2014 Aug;     [PubMed PMID: 25422668]


Kao AM,Arnold MR,Schlosser KA,Siddiqui SL,Prasad T,Colavita PD,Heniford BT, Epiphrenic Diverticulum: 20-Year Single-Institution Experience. The American surgeon. 2018 Jul 1;     [PubMed PMID: 30064580]


Gutschow CA,Schmidt H, [Esophageal diverticula (excluding cricopharyngeal diverticula)]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen. 2018 May;     [PubMed PMID: 29349482]


Thomas ML,Anthony AA,Fosh BG,Finch JG,Maddern GJ, Oesophageal diverticula. The British journal of surgery. 2001 May;     [PubMed PMID: 11350433]


Smith CD, Esophageal strictures and diverticula. The Surgical clinics of North America. 2015 Jun;     [PubMed PMID: 25965138]


Fisichella PM,Jalilvand A,Dobrowolsky A, Achalasia and epiphrenic diverticulum. World journal of surgery. 2015 Jul;     [PubMed PMID: 25609118]


Herbella FA,Dubecz A,Patti MG, Esophageal diverticula and cancer. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 2012 Feb;     [PubMed PMID: 22335201]


Soares R,Herbella FA,Prachand VN,Ferguson MK,Patti MG, Epiphrenic diverticulum of the esophagus. From pathophysiology to treatment. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2010 Dec;     [PubMed PMID: 20437107]


Hukkeri VS,Jindal S,Qaleem M,Tandon V,Govil D, Robotic transhiatal excision of epiphrenic diverticula. Journal of robotic surgery. 2016 Dec;     [PubMed PMID: 27153837]


Theisen J,Stein HJ,Siewert JR, [Therapy of esophageal diverticula]. Therapeutische Umschau. Revue therapeutique. 2001 Mar;     [PubMed PMID: 11305150]