Prostate Abscess

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Continuing Education Activity

A prostate abscess is a complication resulting from the acute infectious process of the prostate. This activity outlines the pathogenesis and evaluation and management of prostate abscess. It also highlights the role of the interprofessional team in evaluating and treating patients with this condition.


  • Identify the etiology of a prostate abscess.
  • Review the risk factors for the formation of a prostate abscess.
  • Describe the typical imaging findings for prostate abscess.
  • Outline the importance of care coordination among the interprofessional teams to improve outcomes for patients affected by prostate abscess.


An abscess usually forms following an inflammatory reaction to an infectious process. It is a collection of purulent material, including cell debris, liquified tissue from infective agents, and enzymes. A prostate abscess is a localized collection of purulent fluid within the prostate, often as a complication of acute bacterial prostatitis (ABP). It is difficult to distinguish acute bacterial prostatitis from a prostate abscess based on the presenting symptoms and physical examination.[1] A prostatic abscess can result in fatal consequences if appropriate measures are not taken, possibly resulting in severe urosepsis and septic shock.[2] In the current day practice of medicine, the number of prostatic abscess patients has considerably declined due to the judicious use of antibiotics. However, a prostate abscess is relatively common in developing countries and also in high-risk patients with diabetes, end-stage renal disease (ESRD) patients on hemodialysis, liver cirrhosis, and immunodeficiency. Due to the lack of clear diagnostic and treatment guidelines, a prostate abscess could be a challenge in the real world and could lead to significant morbidity.[3]


A prostatic abscess is manifested as a complication from prostatitis. Generally, they occur in patients with poorly controlled diabetes or patients with a compromised immune system. Though rare in the current antibiotic era, patients who are not treated appropriately or adequately for acute prostatitis are at high risk of developing an abscess. Men at risk for prostate abscess include those having chronic foley or suprapubic catheters, diabetes, cirrhosis, ESRD, or immunosuppressed patients including HIV patients. Patients who do intermittent self-catheterizations or having bladder outlet obstruction are more prone to prostate abscess formation. Besides, patients with underlying voiding dysfunction either from neurological diseases or due to severe benign prostatic hypertrophy (BPH) are also at high risk. In recent trends, prostate abscess occurring as a complication after a prostate biopsy is more observed in literature which could also occur after some forms of pelvic injury.[4][5][6] 

In old literature of the pre-antibiotic era, sexually transmitted organisms like Neisseria gonorrhoeae and Chlamydia were common pathogens, but most recent data suggests causative etiology be gram-negative bacteria. In a meta-analysis study, Escherichia coli has been attributed to more than 70 percent of the cases followed by Klebsiella, Pseudomonas, Proteus, Enterobacter, and Enterococcus species.[2] Staphylococcus aureus causing prostate abscess is also well documented, possibly through hematogenous infection. Fungal causative organisms like Blastomyces, Cryptococcus, and Nocardia have been listed as causes of prostatic abscess. In a case series of melioidosis, Burkholderia pseudomallei is a common pathogen causing a prostatic abscess.[7]


Overall, the incidence of prostatic abscess can be as high as 0.5% of all urologic diseases, and the mortality rate is between 1 to 16%. Approximately 6% of acute bacterial prostatitis patients develop a prostate abscess.[8] Generally, older age group patients are more affected due to underlying risk factors, but prostate abscess due to sexually transmitted organisms may occur in younger males.


Typically the pathogenesis of prostate abscess is due to suboptimally treated acute bacterial prostatitis. Infection of prostate tissue occurs as a result of the reflux of infected urinary contents into prostatic ducts. Risk factors, as mentioned in the etiology section above, lead to this reflux of infective organisms and aggravated by the underlying systemic disease. Other diseases predisposing to a prostate abscess are chronic prostatitis, epididymitis, gonorrhea, pyelonephritis.[9] Hematogenous dissemination from a distant primary infected focus such as liver abscess, perirenal abscess, appendicitis, diverticulitis, or skin and subcutaneous infections causing bacteremia, primarily due to Staphylococcus aureus could also lead to an abscess in prostatic tissue.[2]

History and Physical

A comprehensive history of all underlying medical illnesses and any immunocompromised state should be promptly obtained in all cases of acute bacterial prostatitis, which helps to suspect and access risks of developing a prostate abscess. The persistence of symptoms in ABP or chronic bacterial prostatitis, especially in patients with risk factors or inadequate antibiotics, should alert providers for the evaluation of an abscess. As this pathology commonly from an ascending urinary tract infection, patients present with a range of urinary symptoms like increased urinary frequency, dysuria, hematuria, and burning urination. More specifically, perineal discomfort should point towards prostate etiology, and in some cases, patients could present with acute urinary retention.[10] Other systemic manifestations of an infectious etiology are evident by fever, chills, myalgia, and low back pain. Physical examination findings that may present in the presence of prostate abscess are purulent urethral discharge, painful rectal examination, and possible fluctuant areas in the prostate.


Diagnosis of prostatic abscess based on history and physical findings is difficult because the symptoms are nonspecific and there is overlap with other lower urinary tract pathology. High clinical suspicion in nonresponding acute prostatitis patients is necessary for timely diagnosis and management. Due to its rare incidence and non-evident clinical features, the diagnosis of a prostatic abscess is sometimes delayed. Necessary investigations, complete blood count with differential, urine analysis, blood culture, and urine culture are ordered to evaluate underlying infectious disease and source of infection. After suspicion of a prostate abscess based on history and physical findings plus basic labs, imaging studies should be obtained to confirm the diagnosis.

Transrectal ultrasound (TRUS) is usually the initial diagnostic test for prostate abscess. Findings of hypoechoic areas with well-defined walls are present.[10] Being a partially invasive procedure, TURP is associated with pain and discomfort for the patient. It can also overlook small abscesses.[11] Computed tomography (CT) scan of the abdomen and pelvis can better delineate the spread of infection to adjacent organs, especially used in more severe and sicker patients.[12] Rarely magnetic resonance imaging (MRI) is needed, which reveals an abscess as a hypodense area on T1, hyperdense on T2 image.[11] Imaging studies not only help in diagnosis but also guide treatment by assisting in the drainage of the abscesses.[10][13]

Treatment / Management

Early diagnosis is favorable because prostatic abscesses require prolonged treatment protocols, sometimes need surgical drainage. Surgical procedures are not necessary in all cases of prostate abscesses. However, surgical drainage has shown to limit the duration of antibiotics and also enhance voiding function in patients with prostatic abscesses.[2] Even though currently, there are no strict guidelines or algorithms for the management of prostatic abscesses, expert consensus, as discussed below, is the guiding standard. After clinical suspicion of a prostate abscess, a diagnostic evaluation takes place with TRUS, based on the size and number of abscesses, conservative management could opt for less than 1 cm size abscess, or additional surgical drainage is needed with ultrasound guidance in abscess size more than 1 cm.

Closely monitoring the response, conservatively treated patients may need drainage if no significant improvement. Patients not responding to initial ultrasound-guided drainage, should have additional imaging like CT scan or MRI to rule out extraprostatic spread of the abscess in which case open drainage may be warranted.[3] According to available literature, smaller abscesses (less than 1 cm) responded well to medical management, whereas larger abscesses (more than 1 cm) responded better with either single or continuous drainage.[14]

Conservative management includes broad-spectrum intravenous antibiotics necessitating inpatient hospital admission. Empiric antibiotic therapy should be targeted mainly towards gram-negative organisms. The antibiotic adjustment could be through urine grams stain results showing evidence to suspect other etiology like gram-positive bacteria or rare causes due to fungal organisms. Commonly used first-line antibiotics are levofloxacin (renal adjusted dose), intravenous carbapenem, broad-spectrum beta-lactam penicillin, or a cephalosporin. The addition of an aminoglycoside (tobramycin 5 mg/kg daily) in the initial treatment regimen could be considered, depending on the severity of the disease. A two-week course of antibiotics is a requirement for complete resolution.[15]

Different approaches have been described for ultrasound-guided drainage of the abscess, namely transrectal drainage (TRUS), transurethral aspiration, and perineal access of the abscess. Each approach has its advantages and disadvantages. In the past, transurethral drainage was the common choice for therapy due to reduced length of hospital stay, but due to possible voiding dysfunction complications, it is out of favor by many experts. Currently, transrectal drainage with transrectal ultrasound guidance is the first choice of approach because of its low risk of complications and is done under local anesthesia, and is repeatable if needed.[16] The transcutaneous perineal route of aspiration is also an option at times. Open surgical drainage is necessary if the abscess has spread to deeper tissue, such as the levator ani muscle.

Differential Diagnosis

The common conditions which could present with similar presentations are urethritis, urinary tract infection, and acute or chronic bacterial prostatitis. A prostate abscess should be strongly suspected if there is a palpable fluctuant mass. Other differential diagnoses while evaluating for a prostate abscess are benign prostatic hyperplasia and perineal abscess, which could mimic by being painful local swelling conditions.


The prognosis of prostate abscess mainly depends on the timely diagnosis and treatment. Early recognition of this complication with appropriate treatment modalities could dramatically improve prognosis. Conservatively treated patients would need a longer duration of antibiotics. Typically, regardless of interventions, the treatment period with antibiotics is longer in cases of prostate abscess compared to ABP patients without abscess.[2] Prognosis also depends on underlying medical conditions contributing to abscess development. Elderly males above 65 years of age, presenting temperatures higher than 100.4 F, history of retention of urine or benign prostatic hypertrophy, and history of chronic catheterization are all considered poor prognostic factors.


Delay in diagnosis and treatment of prostatic abscess can lead to severe complications with significant morbidity and mortality. The infection could be spread locally to adjacent perineal areas which could necessitate more invasive intervention, and also could result in more long-term complications involving the genitourinary functions. Bacteremia and sepsis subsequently causing septic shock and multi-organ failure can potentially occur in severe cases, increasing mortality. Emphysematous prostatitis manifests as having air, and reports exist of purulent material in the prostate gland with cases of Klebsiella organisms.[17]

Deterrence and Patient Education

With the evolution of medicine, a prostate abscess is not just a consequence of untreated prostatitis; men with prostate abscess have multiple medical problems and are debilitated or immunologically compromised. In the younger population, a prostatic abscess can be the initial presentation of immune compromising conditions. In older men, it is becoming more common as a complication of benign prostatic hyperplasia or a prostate biopsy.[18] Due to the challenges in differentiating prostate abscess in patients of ABP, and the importance of long-term adherence to the antibiotics treatments, it is crucial for patients to be aware of this pathology to obtain a prompt diagnosis and timely treatment. Male patients with lower urinary tract infections and prostate infections should be educated to monitor for warning signs and symptoms of abscess formation. As this condition often manifests in diabetic and immunosuppressed patients, real-life scenarios could present more challenges in the management of these patients more than just prostate abscess management.

Enhancing Healthcare Team Outcomes

Prostatic abscesses are often underdiagnosed because symptoms can overlap with several other diseases of the urinary tract. Due to the need for subspeciality evaluation and management, primary care providers and hospitalists should coordinate with surgical services and the urology team to improve outcomes. Interprofessional team communication and care coordination between endocrinologists for underlying diabetes management, infectious diseases, and ancillary services like the wound care team play a significant role in prognosis and complications. The treating clinician can also enlist the assistance of a board-certified infectious disease pharmacist, who can collaborate on agent selection and provide the latest antibiogram data, as well as verifying dosing and performing medication reconciliation. The pharmacist should educate the patient on antibiotic compliance. Also, it is vital that the primary clinicians adequately control the blood glucose, counsel the patient on safe sex practices, and when to seek treatment. These educational processes can benefit from nursing staff who will not only provide training and answer questions but can perform follow-up monitoring and evaluate treatment effectiveness and inform the clinician of any concerns.

Open communication between the team is vital if one wants to prevent morbidity and mortality.  Patients with prostate abscess must be watched closely, as they may experience a high mortality rate if adequate and timely treatment does not occur.[13] This is why interprofessional teamwork is necessary to achieve optimal outcomes for the patient. [Level 5]

Article Details

Article Editor:

Parth Mehta


6/21/2021 10:43:18 AM

PubMed Link:

Prostate Abscess



Faris G,Metz Y,Friedman B,Appel B,Stein A, [Prostatic abscess--diagnosis and treatment]. Harefuah. 2008 Jul;     [PubMed PMID: 18814516]


Lee DS,Choe HS,Kim HY,Kim SW,Bae SR,Yoon BI,Lee SJ, Acute bacterial prostatitis and abscess formation. BMC urology. 2016 Jul 7;     [PubMed PMID: 27388006]


Abdelmoteleb H,Rashed F,Hawary A, Management of prostate abscess in the absence of guidelines. International braz j urol : official journal of the Brazilian Society of Urology. 2017 Sep-Oct;     [PubMed PMID: 28379661]


Brede CM,Shoskes DA, The etiology and management of acute prostatitis. Nature reviews. Urology. 2011 Apr;     [PubMed PMID: 21403661]


Ludwig M,Schroeder-Printzen I,Schiefer HG,Weidner W, Diagnosis and therapeutic management of 18 patients with prostatic abscess. Urology. 1999 Feb;     [PubMed PMID: 9933051]


Tiwari P,Pal DK,Tripathi A,Kumar S,Vijay M,Goel A,Sharma P,Dutta A,Kundu AK, Prostatic abscess: diagnosis and management in the modern antibiotic era. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2011 Mar;     [PubMed PMID: 21422629]


Kozlowska J,Smith S,Roberts J,Pridgeon S,Hanson J, Prostatic Abscess due to {i}Burkholderia pseudomallei{/i}: Facilitating Diagnosis to Optimize Management. The American journal of tropical medicine and hygiene. 2018 Jan;     [PubMed PMID: 29141724]


Ha US,Kim ME,Kim CS,Shim BS,Han CH,Lee SD,Cho YH, Acute bacterial prostatitis in Korea: clinical outcome, including symptoms, management, microbiology and course of disease. International journal of antimicrobial agents. 2008 Feb;     [PubMed PMID: 18065208]


Granados EA,Riley G,Salvador J,Vincente J, Prostatic abscess: diagnosis and treatment. The Journal of urology. 1992 Jul;     [PubMed PMID: 1613887]


Jang K,Lee DH,Lee SH,Chung BH, Treatment of prostatic abscess: case collection and comparison of treatment methods. Korean journal of urology. 2012 Dec;     [PubMed PMID: 23301131]


Singh P,Yadav MK,Singh SK,Lal A,Khandelwal N, Case series: Diffusion weighted MRI appearance in prostatic abscess. The Indian journal of radiology     [PubMed PMID: 21431033]


Thornhill BA,Morehouse HT,Coleman P,Hoffman-Tretin JC, Prostatic abscess: CT and sonographic findings. AJR. American journal of roentgenology. 1987 May;     [PubMed PMID: 3554922]


Aravantinos E,Kalogeras N,Zygoulakis N,Kakkas G,Anagnostou T,Melekos M, Ultrasound-guided transrectal placement of a drainage tube as therapeutic management of patients with prostatic abscess. Journal of endourology. 2008 Aug;     [PubMed PMID: 18673079]


Chou YH,Tiu CM,Liu JY,Chen JD,Chiou HJ,Chiou SY,Wang JH,Yu C, Prostatic abscess: transrectal color Doppler ultrasonic diagnosis and minimally invasive therapeutic management. Ultrasound in medicine     [PubMed PMID: 15219951]


Vyas JB,Ganpule SA,Ganpule AP,Sabnis RB,Desai MR, Transrectal ultrasound-guided aspiration in the management of prostatic abscess: A single-center experience. The Indian journal of radiology     [PubMed PMID: 24347857]


Basiri A,Javaherforooshzadeh A, Percutaneous drainage for treatment of prostate abscess. Urology journal. 2010 Fall;     [PubMed PMID: 21170860]


Kuo PH,Huang KH,Lee CW,Lee WJ,Chen SJ,Liu KL, Emphysematous prostatitis caused by Klebsiella pneumoniae. Journal of the Formosan Medical Association = Taiwan yi zhi. 2007 Jan;     [PubMed PMID: 17282974]


Ackerman AL,Parameshwar PS,Anger JT, Diagnosis and treatment of patients with prostatic abscess in the post-antibiotic era. International journal of urology : official journal of the Japanese Urological Association. 2018 Feb;     [PubMed PMID: 28944509]