Total Knee Replacement Techniques

Continuing Education Activity

Total knee arthroplasty (TKA) is a viable treatment for symptomatic osteoarthritis of the knee refractory to conservative measures. In those with end-stage degenerative changes compromising the articular cartilage affecting multiple compartments of the knee, the literature has yet to identify a potentially viable alternative option for the regeneration of cartilage. TKA has shown reproducible, long-term, successful results in patients as demonstrated by outcomes such as decreased pain and improved overall quality of life. This activity reviews the indications, complications, and techniques for total knee arthroplasty and highlights the role of interprofessional providers in managing patients with osteoarthritis of the knee.


  • Describe the techniques for total knee arthroplasty.
  • Review the indications for total knee arthroplasty.
  • Identify the complications of total knee arthroplasty.
  • Explain a structured, interprofessional team approach to provide effective care to and appropriate surveillance of patients undergoing total knee arthroplasty.


Total knee arthroplasty (TKA) is a viable treatment for symptomatic osteoarthritis of the knee refractory to conservative measures. In those with end-stage degenerative changes compromising the articular cartilage affecting multiple compartments of the knee, the literature has yet to identify a potentially viable alternative option for the regeneration of cartilage. Thus, TKA has demonstrated reproducible, long-term, successful results in such patients concerning outcomes of decreased pain and improved overall quality of life.[1]

Recent estimates project that by the year 2030, there will be 3.48 million TKAs performed annually.[2] Although it is an extremely common and increasingly routine surgery, attention to detail is critical during the procedure to ensure that a well-balanced and functional TKA is performed to mitigate the risks of implanting components that might otherwise be subject to increased wear and early failure. Even with appropriate techniques, new technologic advances, and a better understanding of knee kinematics, approximately 1 out of 5 people that undergo a TKA will remain unsatisfied.[3][4] There are numerous TKA designs and different levels of constraint that may be necessary for particular cases. Unicompartmental arthroplasty, cruciate retaining, and posterior stabilizing implants are typically used as potential index procedure options. However, in patients with significant varus/valgus instability, those undergoing revision surgery including component revisions, patients with preexisting poor bone quality, or in the setting of appreciable osseous defects, more constrained prosthetic components are given consideration. These include but are not limited to semi-constrained, hinged, or distal femoral replacement options.[5]

Anatomy and Physiology

The knee is made up of 3 separate compartments:[6]

  • Medial tibiofemoral joint 
  • Lateral tibiofemoral joint 
  • Patellofemoral joint

The knee is typically described as a hinged joint; however, there are more complex and subtle motion and dynamic considerations. Physiologically, the knee also undergoes axial rotation and femoral "rollback" in deeper degrees of flexion. Additionally, terminal rotatory motion, known as the "screw home mechanism," occurs as the tibia externally rotates when the knee goes into terminal extension. The lateral tibial plateau is convex and sits more proximal than the medial tibial plateau, concave. The medial femoral condyle is larger than the lateral side. 60% of the force through the knee joint occurs on the medial tibial plateau. Thus, the medial tibial plateau is of more dense bone, and this is also why the more common wear pattern seen in osteoarthritis occurs on the medial side.[7]

Numerous ligaments act on the knee to provide stability of the joint, including:[8][9][10]

  • Anterior cruciate ligament (ACL)
    • Important for axial rotation as well as preventing anterior translation of the tibia on the femur
  • Posterior cruciate ligament (PCL)
    • Important to prevent posterior translation of the tibia on the femur and allow for femoral rollback.
  • Lateral collateral ligament (LCL)
    • Varus restraint and is typically attenuated in significant varus deformity 
  • Medial collateral ligament (MCL)
    • Valgus restraint and is typically attenuated in significant valgus deformity. 
  •  Posterolateral corner (PLC)
    • The primary stabilizer of external tibial rotation

Mechanical Alignment[3] 

The distal femur is in approximately 9 degrees of anatomic valgus relative to the joint line, while the proximal tibia in 3 degrees of anatomic varus relative to the joint line. 

The typical patellar Q angle is between 13 degrees and 19 degrees, with an increased Q angle increases the risk of patellar maltracking and dislocation.


The most common underlying diagnosis and indication for TKA are end-stage, degenerative osteoarthritis of the knee, with approximately 94 to 97% of knee replacements performed for primary or post-traumatic osteoarthritis.[11] These patients must have degenerative changes with pain and limitation of function in the knee that has failed conservative and non-operative measures. Other underlying diagnoses that may be treatable with a knee replacement include rheumatoid arthritis, peri-articular fractures, or malignancy. However, patients with malignancy may commonly require megaprostheses.[8]


There are few absolute contraindications for TKA, including an active infection in the joint and remote infection or bacteremia. Relative contraindications include a significant vascular disease that may lead to poor wound healing and increased risk for infection. There is currently discussion and controversy in the literature about risk stratification and increased complications associated with obesity. Patients with a BMI greater than 30 have an increased risk of infection and medical complications compared to non-obese patients. This risk further increases for those with a BMI greater than 40. Patients with BMI over 40 were found to have a statistically significant increase in superficial infection, deep infection, operative time, deep vein thrombosis (DVT), length of stay, renal insufficiency, reoperation, and wound dehiscence.[12]


Each implant company has a specific system with trays that come with the necessary tools and trial components. The basic equipment that will be used in all cases and will improve the efficiency and safety of the case include: 

  • Standard operating table
  • De Mayo leg holder, paint roller, or other equivalent patient positioning instrumentation
  • Tourniquet
    • Overall use remains debated in the literature
    • Use and duration is surgeon-specific
  • Retractors
  • Osteotomes
  • Sagittal saw 
  • Mallet
  • Lamina spreaders
  • Cement-specific equipment
    • Cement mixer system
    • Pressurizing gun
  • Pulse lavage irrigation 
  • Suction
  • Bovie electrocautery

In revision cases, may also require other equipment, including:

  • Curettes 
  • Reamers
  • Cones
  • Sleeves
  • Stemmed options including offset adjusting capabilities
  • Bone grafting options

Implant Types

Implant types have continued to evolve since the 1950s. Insall et al. initially described in the 1970s the different models of knee prostheses. He placed them into two categories; condylar replacements that spared ligaments and hinged-type components that sacrificed the ligaments. Four models were described, with increasing complexity in each model:[13] 

  1. Unicondylar 
  2. Duocondylar 
  3. Geometric 
  4. Guepar

In modern arthroplasty, most implants are a derivative of these models that were initially described. They include unicompartmental, cruciate retaining, posterior stabilizing, constrained non-hinged, constrained hinged prosthetic components from least complex to the most complex.[5][14][15]

Cruciate Retaining (CR)

The ACL is sacrificed; overall feasibility mandates a competent and functional PCL. 

It can be used in those with mild varus/valgus deformity. It should be avoided in those with inflammatory arthritis due to increased risk for short-term or delayed rupture of PCL. 


  • Fewer patellar complications (theoretical)
  • Increased quadriceps strength (controversial, depends in part on surgical exposure utilized)
  • Improved stair climbing 
  • Preserved PCL proprioception (theoretical)
  • Lower shear forces on the tibial component 
  • Improved femoral bone stock preservation 
  • Preserves near-normal knee kinematics 
  • Avoids cam-post jump complication that exists in posterior stabilized prosthetic components


  • Risk of postoperative PCL degeneration or rupture that can lead to flexion instability 
  • Tight PCL can lead to increased wear on polyethylene and dysfunctional TKA kinematics.

Posterior Stabilizing (PS)

It can be used in those with absent PCL, inflammatory arthritis and may be beneficial in those with a previous patellectomy as it can add some anteroposterior stability that is absent due to the weak extensor mechanism. PS femoral prosthetic component contains a box in the femoral component with a post on the polyethylene liner that substitutes for the resected PCL. 


  • It can theoretically be easier to achieve ligamentous balance in the knee without having to worry about accounting for the physiologic effects of the intact PCL
  • Greater deformity correction compared to cruciate-retaining implants
  • Theoretically improved knee range of motion 
  • Decreased polyethylene wear due to congruent articular surfaces


  • Cam-post jump of the post over the femoral box, typically due to mid-late flexion instability
  • Polyethylene wear on the post can lead to osteolysis.
  • Patellar clunk that may occur due to a soft tissue nodule and is present when going from flexion into extension 
  • The increased theoretical risk of technical error which can involve elevating the joint line 

Overall, multiple studies have not demonstrated a significant difference in function, satisfaction, or implant survival between cruciate-retaining and posterior stabilizing implants. 

Constrained Non-Hinged

Varus-valgus constrained design is used in cases where there is LCL or MCL deficiency, moderate bone loss, or flexion gap laxity. This implant has a large tibial post with a deep femoral box. 


  • Allows for coronal stability in severe coronal bone deformities


  • Increased femoral bone loss and is a poor option in younger patients unless necessary. 
  • Increased risk of aseptic loosening due to increased constraint 
  • Increased polyethylene wear and increased risk of cam fracture 

Constrained Hinge

Rotating hinge prostheses are used in complex revision arthroplasty cases with significant bone loss, ligamentous laxity, or oncologic cases. Femoral and tibial components link with an axle, and the tibial bearing can rotate around the tibial platform. This rotation allows for a lower constraint and, therefore, a decreased risk of aseptic loosening. Early implants were uniplanar without allowing rotation and had a high rate of aseptic loosening.


  • Very versatile and has application for many salvage cases


  • Significant bone resection needed for implant 
  • Although lower with a rotating hinge, still at risk for aseptic loosening due to increased constraint.


Total joint arthroplasty has transitioned from a fee for service to a bundled payment to incentivize quality of care over quantity of cases. In 2015, the Center for Medicare and Medicaid Services (CMS) announced the Comprehensive Care for Joint Replacement Model (CJR). Bozic et al. in 2014 demonstrated that 70% of the total cost was post-discharge, and they have created CJR in hopes of stimulating a reduction in cost and complications. This effort has led to the development of standardized protocols and an interprofessional approach for patients undergoing knee replacement. At our institution, personnel integral to the success of a knee replacement include:[16] 

  • Primary care physician
  • Joint class instructor
  • Preoperative, intraoperative, and post-anesthesia nurses 
  • Scrub technician, circulating RN
  • Implant representative 
  • Physician assistant/first assistant 
  • Resident physician 
  • Orthopedic surgeon 
  • Case manager 
  • Inpatient occupational and physical therapist 
  • Outpatient physical therapist 
  • Home health nurse 


Non-Operative Management

Numerous non-operative treatments are employed in the pre-surgical management of knee arthroplasty. Treatments include both pharmacologic and non-pharmacologic options. Multiple studies have investigated these different treatment options, and guidelines have been put in place by the American Academy of Orthopaedic Surgeons in the 2013 evidence-based guidelines, 2nd edition.[17]

The AAOS recommends with strong evidence for low-impact aerobic exercises, neuromuscular education, and strengthening. They also strongly recommend the use of NSAIDs and tramadol.[18]

The AAOS recommends moderate weight loss in patients with a BMI greater than 25.

The AAOS recommends strongly against acupuncture, glucosamine/chondroitin, and viscosupplementation.

The AAOS recommends moderate against lateral wedge insoles.

The AAOS cannot recommend for or against manual therapy (i.e., chiropractic, joint manipulation), physical agents including electrotherapeutic modalities, biologic injections, corticosteroid injections, valgus directing force brace, acetaminophen, opioids, or pain patches. 

Preoperative Evaluation

A review of the literature did not demonstrate a uniform protocol as to what preoperative evaluation is necessary before knee replacement. A thorough history and physical exam are necessary. Comorbidities, smoking status, alcohol consumption, and mental status should all undergo evaluation. The patient's risk for the development of thromboembolic events should be a consideration. However, typically, most patients will undergo evaluation and preoperative clearance by their primary care provider and potentially cardiologist if significant cardiac comorbidities are present. Other subspecialty preoperative evaluations may be necessary depending on patients' other comorbidities (i.e., rheumatology, nephrology, neurology). Bernstein et al. developed a protocol that assessed patients for 19 different risk factors. Identifying these risk factors allowed for preoperative intervention, and these patients were found to have a statistically significant shorter length of stay and lower average total direct variable cost. No difference was noted in patients' 90-day readmission rate.[19][15]

Preoperative Surgical Planning[15]

It is essential to assess for previous surgical incisions, patients' limb-lengths, limb deformity, the range of motion, ligamentous stability, and gait. Patients' neurovascular status should also be considered; ankle-brachial index (ABI) may be a prudent screening, and if less than 0.9, a vascular consultation should be obtained. Patients with preexisting peripheral vascular disease should also have their ABI assessed. 

Plain radiography typically provides sufficient detail, and further studies are typically not necessary. Weight-bearing AP, lateral and sunrise views should be routinely performed. AP hip to ankle x-rays allow for evaluation of extra-articular deformities and allow for assessment of the mechanical axis. Radiographic markers can be placed during imaging to allow for the use of templating software to assess for estimated implant sizing and positioning. A lateral patellar shift of more than 3mm was an independent risk factor for patellar maltracking. Images should be interpreted to assess for Insall-Salvati ratio, a preexisting slope of the tibial plateau, and coronal alignment. Custom implants are made based on CT or MRI sequences, and these studies should be performed when a custom implant is desired. Custom implants can be particularly helpful in patients with significant deformity where intramedullary or extra-medullary guides will not work, as well as in patients with preexisting hardware. 

Laboratory Testing[15]

Basic preoperative labs should be performed such as CBC, BMP, HbA1c in patients with diabetes mellitus. A goal of HbA1c of less than 7.0 is desirable; however, studies have shown that a HbA1c under 8.0 is acceptable to avoid excessive delay and complications in knee replacement. Many centers also perform preoperative urinalysis and nasal swabs/decolonization in potential MRSA carriers.[20] Other considerations include checking a total lymphocyte count (TLC) and serum albumin as these are markers of potential underlying malnutrition that may increase the risk of wound complications following the elective TKA procedure.


Surgical Technique[3]

Patients are typically placed supine on the operative table; a general or spinal anesthetic is administered. A systematic review performed by Johnson et al. found no statistically significant differences between the two, including mortality, surgical duration, or nerve palsy.[21] Typically a standard midline incision with a medial parapatellar arthrotomy is used. However, other approaches include the lateral parapatellar approach, midvastus, and subvastus approach. More extensile approaches include the quadriceps snip, V-Y turndown, and tibial tubercle osteotomy.[22] It is essential during the approach to maintain thick skin flaps and to respect the blood flow that comes from medial to lateral. Maintaining a small cuff is necessary during the arthrotomy to allow for adequate repair at the conclusion of the procedure. The medial soft tissues at the proximal tibia are skeletonized off of the bone, and a soft tissue release is performed medially. The same procedure is performed on the lateral side. However, most cases involve varus deformities, and a more extensive medial release is the choice. The infrapatellar fat pad can either be partially or completely excised. The medial and lateral meniscus, as well as ACL, will require excision. The PCL should also be sacrificed if a posterior stabilizing implant is desired. It is not necessary to resurface the patella in all cases. However, in patients with significant anterior knee pain or patellofemoral arthritis, it should be. It is worth noting that the revision rate and incidence of anterior knee pain are higher in those that do not undergo resurfacing. But those with resurfacing have a higher chance of complications such as tendon injury or fracture. Overall the patient satisfaction rates are equal between the two treatments.[23]

The sequence of steps during knee arthroplasty will be dependent on the technique selected by the operative surgeon. These techniques include: 

1) Measured Resection

  • Traditionally, it was associated with cruciate-retaining implants; however, it can also be used for PS implants.
  • Most surgeons desire a neutral mechanical axis, and the femur is cut in 5 to 7 degrees of valgus with approximately 9 to 10 mm of bony resection distally. The tibia is cut perpendicularly to the tibial axis. Typically an intramedullary guide is utilized on the femur, and an extramedullary guide is utilized on the tibia. The anatomic slope of the tibial plateau is restored if a CR implant is to be used. Should be a neutral tibial plateau cut if a PS implant is being used due to the risk for the CAM jump phenomenon with an increased tibial slope. 
  • Anatomic landmarks are used to reference a neutral femoral implant rotation. 
    1. Transepicondylar axis (TEA): Connects lateral condyle prominence to sulcus of the medial epicondyle. Implants placed parallel to this will provide a rectangular flexion gap and result in improved patellofemoral tracking, femorotibial kinematics, and coronal stability.
    2. Whiteside line (AP axis of the femur): Starts at the center of the trochlear sulcus and ends posteriorly at the midpoint of the intercondylar notch and typically is perpendicular to TEA. 
    3. Posterior condylar axis (PCA): Goes based upon a line connecting posterior condyles; in most cases, externally rotating the posterior condylar axis by 3 degrees will create a line parallel to the TEA. This, however, can be very deceiving in patients with a valgus knee and hypoplastic lateral femoral condyle and can lead to malrotation of the implant. 
  • Osteophytes should be removed before any bone cuts.
  • The pitfall of the technique is that it is difficult to perform soft-tissue releases after performing bony cuts. Ligament releases after bony cuts can affect the flexion/extension gaps and lead to poor balancing. Changing ligament tension in extension will affect the flexion gap and vice versa. 
  • There is an increased incidence of femoral condylar liftoff in this technique compared to gap balancing. 

2) Gap Balancing 

  • Traditionally associated with PS implants, but can be used for CR as well. 
  • Before any bony cuts or soft tissue release, the removal of all osteophytes is necessary; this is particularly important in gap balancing because removing osteophytes after balancing will change the ligamentous tension and will affect flexion/extension gaps. 
  • Typically a proximal tibial cut is performed then lamina spreaders are placed on medial and lateral sides to assess tension on both sides in extension. Structures are released until a neutral alignment, and symmetric extension gap are achieved. 
  • The same steps are then performed with the knee at 90 degrees of flexion. A rectangular flexion gap equal to the extension gap is desired, the posterior femoral condyle cuts are then performed. 
  • Joint line elevation is a potential pitfall of this technique and can lead to abnormal contact forces on the patellofemoral joint as well as mid-flexion instability. 

3) Hybrid Technique

  • The hybrid technique is a blend of the two techniques described above. 

Patellar maltracking is one of the most common complications encountered in knee arthroplasty. Iatrogenic causes of the complication can be avoided by: 

  • Lateralizing femoral and tibial implants 
  • Avoiding internal rotation of the femoral and tibial prosthesis 
  • Avoiding overstuffing or under-sizing patellar component 
  • Medializing patellar component 

A uniform strategy for wound closure does not exist, and many studies have found different materials to be superior. Typically a heavy polyethylene terephthalate suture or barbed suture is used for arthrotomy closure. Followed by absorbable suture or barbed suture is used for the deep and superficial dermis. Skin closure can be either a running non-braided absorbable suture with either cyanoacrylate tissue glue/butterfly bandages or staples. Silver-lined dressings can be used and should be maintained for several days without being removed until drainage has stopped. For complex revisions or high-risk patients, incisional wound vacs or negative pressure dressings are also an option.[8]


Periprosthetic Fracture 

Periprosthetic fractures can occur in the distal femur, proximal tibia, or patella. They are most commonly located in the supracondylar region of the distal femur. The most common classification system used for periprosthetic fractures of the distal femur is the Lewis and Rorabeck classification. In this classification system, type-I is non-displaced with a stable component; type-II has more than 5mm of displacement or greater than 5 degrees of angulation with a stable component, and type-III has a loose component. There are several additional classification systems; All of which fail to classify intra-operative periprosthetic fractures. The anatomic location is typically used to describe these fractures. Risk factors that may predispose patients to periprosthetic fractures include:

  • Anterior notching of the femur
  • Osteoporosis, osteolysis
  • Implant loosening
  • Rheumatoid arthritis
  • Neurologic disorder
  • Corticosteroid use
  • Increased age
  • Female sex

Treatment options can include open reduction internal fixation, knee immobilizer, revision arthroplasty if components are loose, or distal femoral replacement if there is not adequate bone stock or significant comminution is present.[24][25][26]

Prosthetic Joint infection[27][28][29][30][31][32]

  • Occurs in 1 to 2% of primary knee replacements
  • Most common pathogens: 
    • Staphylococcus aureus
    • Staphylococcus epidermidis
  • Acute infection
    • Within 6 weeks of surgery 
  • Chronic infection 
    • After 6 weeks of surgery
  • Laboratory evaluation 
    • CBC
    • ESR
    • CRP
    • IL-6
    • Synovial analysis 
      • WBC count 
        • 27800 is the cutoff in the first 6 weeks after surgery 
        • Following 6 weeks, a WBC count of 1100 is suggestive of infection
      • Culture 
      • Gram stain 
      • Alpha-defensin
  • Imaging: 
    • Can demonstrate periosteal reaction, implant loosening, or osteolysis. 
    • The bone scan is useful if other tests are equivocal. Its sensitivity is 99%%; however, it has very poor specificity (30 to 40%)
  • Treatment: 
    • IV antibiotics for 12 weeks
    • In acute infections, a polyethylene liner exchange in addition to synovectomy and irrigation and debridement can be attempted. 
      • 50 to 55% success rate 
    • In chronic infections or those that have failed other treatments, a two-stage revision is recommended and is the gold standard in the United States. In Europe, a one-stage revision is routinely performed. 
    • Two-stage revision involves the placement of an antibiotic spacer for approximately 2 to 3 months. 
      • These spacers typically have 3 grams of vancomycin and 4 grams of tobramycin per 40-gram bag of cement used. 
      • Spacers can be either static or articulating. 
      • With a two-stage revision, repeat frozen section should be performed before reimplantation.
        • Persistence of infection is demonstrated by greater than 5 PMN per hpf in 5 hpf at x400 magnification.

Other Complication[33][34][35][36][37][38]

  • Aseptic loosening 
  • Patellar maltracking
  • Extensor mechanism disruption 
  • Instability 
  • Stiffness
  • Patellar clunk 
  • Vascular injury 
  • Peroneal nerve palsy 
  • Wound complications 
  • Metal hypersensitivity reaction 
  • Heterotopic ossification 

Clinical Significance

Understanding joint arthroplasty principles and increasing the quality and continuity of care is very important. As stated earlier, 3.48 million total knee arthroplasty's (TKA) will be performed annually by 2030.[2] Currently, 20% of patients undergoing TKA remain dissatisfied for a variety of reasons.[3] This dissatisfaction places a heavy burden and cost on the healthcare system. More importantly, due diligence is a priority and must take place before performing a TKA in every patient as a compromised or negative outcome results in a multitude of suboptimal downstream effects. Furthermore, as alternative payment models and bundled payment initiatives continue to move across the entire healthcare system,[39] including the entire orthopedic subspecialty fields,[40] all healthcare providers, hospitals, and healthcare facilities are under increasing pressure to provide high quality, value-based healthcare at all levels at an increasingly efficient manner.[41][42]

Enhancing Healthcare Team Outcomes

The Bundled Payments for Care Improvement initiative (BPCI) by CMS has lead to systematic approaches by many institutions. Clinical care pathways (CCP) include an interprofessional team such as nursing, physical therapy occupational therapy, anesthesiologists, orthopedic surgeons, dietitians, and general surgeons. In patients suffering from obesity who are at increased risk of complications, potential weight loss with the assistance of a dietitian can be achieved. If they are unable to lose the necessary weight, bariatric surgery is a consideration. Immediate access to physical therapy, joint education classes, and improved pain management through nerve blocks and multimodal therapies has led to decreased opioid use and quicker mobilization. The implementation of these CCP's has shown improved patient-reported outcomes, early mobilization, reduced hospital length of stay, and reduction in hospital costs. Appropriate pre-admission testing and evaluation by primary care physicians and cardiac optimization have reduced the length of stay, mortality, and intensive care unit admissions.[43][44] [Level 3]

Article Details

Article Author

Anthony Gemayel

Article Editor:

Matthew Varacallo


5/1/2021 4:26:22 PM



Varacallo MA,Herzog L,Toossi N,Johanson NA, Ten-Year Trends and Independent Risk Factors for Unplanned Readmission Following Elective Total Joint Arthroplasty at a Large Urban Academic Hospital. The Journal of arthroplasty. 2017 Jun     [PubMed PMID: 28153458]


Kurtz S,Ong K,Lau E,Mowat F,Halpern M, Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. The Journal of bone and joint surgery. American volume. 2007 Apr;     [PubMed PMID: 17403800]


Sheth NP,Husain A,Nelson CL, Surgical Techniques for Total Knee Arthroplasty: Measured Resection, Gap Balancing, and Hybrid. The Journal of the American Academy of Orthopaedic Surgeons. 2017 Jul;     [PubMed PMID: 28644188]


Varacallo M,Chakravarty R,Denehy K,Star A, Joint perception and patient perceived satisfaction after total hip and knee arthroplasty in the American population. Journal of orthopaedics. 2018 Jun     [PubMed PMID: 29643693]


Morgan H,Battista V,Leopold SS, Constraint in primary total knee arthroplasty. The Journal of the American Academy of Orthopaedic Surgeons. 2005 Dec;     [PubMed PMID: 16330513]


Cantrell AJ,Varacallo M, Anatomy, Bony Pelvis and Lower Limb, Leg Bones . 2018 Jan     [PubMed PMID: 30725709]


Hyland S,Varacallo M, Anatomy, Bony Pelvis and Lower Limb, Popliteus Muscle . 2018 Jan     [PubMed PMID: 30252340]


Varacallo M,Johanson NA, Total Knee Arthroplasty 2018 Jan;     [PubMed PMID: 29763071]


Gupton M,Terreberry RR, Anatomy, Bony Pelvis and Lower Limb, Knee 2018 Jan;     [PubMed PMID: 29763193]


Raj MA,Varacallo M, Posterior Cruciate Ligament (PCL) Knee Injuries . 2018 Jan     [PubMed PMID: 28613477]


Van Manen MD,Nace J,Mont MA, Management of primary knee osteoarthritis and indications for total knee arthroplasty for general practitioners. The Journal of the American Osteopathic Association. 2012 Nov;     [PubMed PMID: 23139341]


Zusmanovich M,Kester BS,Schwarzkopf R, Postoperative Complications of Total Joint Arthroplasty in Obese Patients Stratified by BMI. The Journal of arthroplasty. 2018 Mar;     [PubMed PMID: 29089223]


Insall JN,Ranawat CS,Aglietti P,Shine J, A comparison of four models of total knee-replacement prostheses. The Journal of bone and joint surgery. American volume. 1976 Sep;     [PubMed PMID: 956219]


Sculco TP, The role of constraint in total knee arthoplasty. The Journal of arthroplasty. 2006 Jun;     [PubMed PMID: 16781430]


Tanzer M,Makhdom AM, Preoperative Planning in Primary Total Knee Arthroplasty. The Journal of the American Academy of Orthopaedic Surgeons. 2016 Apr;     [PubMed PMID: 26990712]


McLawhorn AS,Buller LT, Bundled Payments in Total Joint Replacement: Keeping Our Care Affordable and High in Quality. Current reviews in musculoskeletal medicine. 2017 Sep;     [PubMed PMID: 28741101]


Jevsevar DS,Brown GA,Jones DL,Matzkin EG,Manner PA,Mooar P,Schousboe JT,Stovitz S,Sanders JO,Bozic KJ,Goldberg MJ,Martin WR 3rd,Cummins DS,Donnelly P,Woznica A,Gross L, The American Academy of Orthopaedic Surgeons evidence-based guideline on: treatment of osteoarthritis of the knee, 2nd edition. The Journal of bone and joint surgery. American volume. 2013 Oct 16;     [PubMed PMID: 24288804]


Brutzkus JC,Varacallo M, Naproxen . 2018 Jan     [PubMed PMID: 30247840]


Bernstein DN,Liu TC,Winegar AL,Jackson LW,Darnutzer JL,Wulf KM,Schlitt JT,Sardan MA,Bozic KJ, Evaluation of a Preoperative Optimization Protocol for Primary Hip and Knee Arthroplasty Patients. The Journal of arthroplasty. 2018 Dec;     [PubMed PMID: 30201213]


Hacek DM,Robb WJ,Paule SM,Kudrna JC,Stamos VP,Peterson LR, Staphylococcus aureus nasal decolonization in joint replacement surgery reduces infection. Clinical orthopaedics and related research. 2008 Jun;     [PubMed PMID: 18347889]


Johnson RL,Kopp SL,Burkle CM,Duncan CM,Jacob AK,Erwin PJ,Murad MH,Mantilla CB, Neuraxial vs general anaesthesia for total hip and total knee arthroplasty: a systematic review of comparative-effectiveness research. British journal of anaesthesia. 2016 Feb;     [PubMed PMID: 26787787]


Liu HW,Gu WD,Xu NW,Sun JY, Surgical approaches in total knee arthroplasty: a meta-analysis comparing the midvastus and subvastus to the medial peripatellar approach. The Journal of arthroplasty. 2014 Dec;     [PubMed PMID: 24295800]


Meneghini RM, Should the patella be resurfaced in primary total knee arthroplasty? An evidence-based analysis. The Journal of arthroplasty. 2008 Oct;     [PubMed PMID: 18701250]


Bezwada HP,Neubauer P,Baker J,Israelite CL,Johanson NA, Periprosthetic supracondylar femur fractures following total knee arthroplasty. The Journal of arthroplasty. 2004 Jun;     [PubMed PMID: 15188103]


Mortazavi SM,Kurd MF,Bender B,Post Z,Parvizi J,Purtill JJ, Distal femoral arthroplasty for the treatment of periprosthetic fractures after total knee arthroplasty. The Journal of arthroplasty. 2010 Aug;     [PubMed PMID: 20171053]


Kim KI,Egol KA,Hozack WJ,Parvizi J, Periprosthetic fractures after total knee arthroplasties. Clinical orthopaedics and related research. 2006 May;     [PubMed PMID: 16568003]


Kelly MP,Darrith B,Hannon CP,Nam D,Courtney PM,Della Valle CJ, Synovial Fluid Alpha-Defensin Is an Adjunctive Tool in the Equivocal Diagnosis of Periprosthetic Joint Infection. The Journal of arthroplasty. 2018 Nov;     [PubMed PMID: 30017218]


Triantafyllopoulos GK,Poultsides LA,Zhang W,Sculco PK,Ma Y,Sculco TP, Periprosthetic knee infections treated with irrigation and debridement: outcomes and preoperative predictive factors. The Journal of arthroplasty. 2015 Apr;     [PubMed PMID: 25466169]


Nodzo SR,Bauer T,Pottinger PS,Garrigues GE,Bedair H,Deirmengian CA,Segreti J,Blount KJ,Omar IM,Parvizi J, Conventional diagnostic challenges in periprosthetic joint infection. The Journal of the American Academy of Orthopaedic Surgeons. 2015 Apr;     [PubMed PMID: 25808966]


Kuzyk PR,Dhotar HS,Sternheim A,Gross AE,Safir O,Backstein D, Two-stage revision arthroplasty for management of chronic periprosthetic hip and knee infection: techniques, controversies, and outcomes. The Journal of the American Academy of Orthopaedic Surgeons. 2014 Mar;     [PubMed PMID: 24603825]


Della Valle C,Parvizi J,Bauer TW,DiCesare PE,Evans RP,Segreti J,Spangehl M,Watters WC 3rd,Keith M,Turkelson CM,Wies JL,Sluka P,Hitchcock K, American Academy of Orthopaedic Surgeons clinical practice guideline on: the diagnosis of periprosthetic joint infections of the hip and knee. The Journal of bone and joint surgery. American volume. 2011 Jul 20;     [PubMed PMID: 21792503]


Jacobs C,Christensen CP,Berend ME, Static and mobile antibiotic-impregnated cement spacers for the management of prosthetic joint infection. The Journal of the American Academy of Orthopaedic Surgeons. 2009 Jun;     [PubMed PMID: 19474445]


Dobbs RE,Hanssen AD,Lewallen DG,Pagnano MW, Quadriceps tendon rupture after total knee arthroplasty. Prevalence, complications, and outcomes. The Journal of bone and joint surgery. American volume. 2005 Jan;     [PubMed PMID: 15634812]


Dalury DF,Jiranek WA, The incidence of heterotopic ossification after total knee arthroplasty. The Journal of arthroplasty. 2004 Jun;     [PubMed PMID: 15188102]


Maloney WJ, The stiff total knee arthroplasty: evaluation and management. The Journal of arthroplasty. 2002 Jun;     [PubMed PMID: 12068410]


Schwab JH,Haidukewych GJ,Hanssen AD,Jacofsky DJ,Pagnano MW, Flexion instability without dislocation after posterior stabilized total knees. Clinical orthopaedics and related research. 2005 Nov;     [PubMed PMID: 16239790]


Schroer WC,Berend KR,Lombardi AV,Barnes CL,Bolognesi MP,Berend ME,Ritter MA,Nunley RM, Why are total knees failing today? Etiology of total knee revision in 2010 and 2011. The Journal of arthroplasty. 2013 Sep;     [PubMed PMID: 23954423]


Nercessian OA,Ugwonali OF,Park S, Peroneal nerve palsy after total knee arthroplasty. The Journal of arthroplasty. 2005 Dec;     [PubMed PMID: 16376265]


de la Torre JI,Varacallo M, Accountable Care Organization (ACO) . 2018 Jan     [PubMed PMID: 28846320]


Varacallo MA,Mattern P,Acosta J,Toossi N,Denehy KM,Harding SP, Cost Determinants in the 90-Day Management of Isolated Ankle Fractures at a Large Urban Academic Hospital. Journal of orthopaedic trauma. 2018 Jul     [PubMed PMID: 29738399]


Varacallo M,Knoblauch DK, Occupational Injuries and Workers' Compensation Management Strategies . 2018 Jan     [PubMed PMID: 29262238]


Jen MY,Varacallo M, Predictive Medicine . 2018 Jan     [PubMed PMID: 28722970]


Rutherford RW,Jennings JM,Dennis DA, Enhancing Recovery After Total Knee Arthroplasty. The Orthopedic clinics of North America. 2017 Oct;     [PubMed PMID: 28870300]


Feng JE,Novikov D,Anoushiravani AA,Schwarzkopf R, Total knee arthroplasty: improving outcomes with a multidisciplinary approach. Journal of multidisciplinary healthcare. 2018;     [PubMed PMID: 29416347]