Continuing Education Activity

Pancreatitis is defined as inflammation of the pancreas, leading to damage and dysfunction of the retroperitoneal organ. It can be classified as Acute and Chronic Pancreatitis. There are various etiologies of pancreatitis, the most common being alcohol and gallstones. The others include drugs, infections, postoperative, genetic causes to name a few. This activity describes the diagnosis of Pancreatitis and precise staging of disease severity using the Ranson score and Modified Atlanta Classification respectively. It outlines the various treatment guidelines and protocols while highlighting the importance of an organized interprofessional team to treat pancreatitis and improve outcomes. It also illustrates the various complications of pancreatitis and their management.

Objectives:

• Describe the clinical features of alcoholic pancreatitis.
• Outline an efficient diagnostic approach to alcohol pancreatitis.
• Explain the various treatment strategies of alcoholic pancreatitis and its complications.
• Address the importance of the interprofessional team in the systematic management of alcoholic pancreatitis.

Introduction

Alcohol use syndrome is one of the most common causes of both acute and chronic pancreatitis.

Acute pancreatitis (AP) is a necro-inflammatory disease resulting from exocrine cell destruction by infiltrating inflammatory cells. The diagnostic criteria are typically when a patient presents with characteristic symptoms, elevated lipase levels, and distinct imaging findings. Treatment is mostly supportive as there is no specific pharmacotherapy for this disease. Acute pancreatitis will either resolve with the pancreas fully regenerating, lead to transient organ failure, or progress to cause systemic inflammation and multi-organ failure. In these severe cases, treatment may require antibiotics and more invasive therapies.

Chronic pancreatitis (CP) is believed to result from recurrent attacks of acute pancreatitis, leading to the development of pancreatic insufficiency, steatorrhea, diabetes, pancreatic calcification, and fibrosis.  While alcohol and its by-products alone do not directly cause this disease, they can predispose the pancreas to damage from otherwise benign agents. As a result, one of the main strategies to prevent recurrent attacks involve providing alcohol (and smoking) cessation counseling and strategies to patients.

Etiology

Chronic alcohol consumption causes 17% to 25% of acute pancreatitis cases worldwide and is the second most common cause of AP after gallstones. It usually manifests in patients with over five years of ongoing, substantial alcohol use (~4-5 drinks daily) and only rarely occurs from isolated binge drinking [1]. The type of alcohol ingested does not affect the risk of developing pancreatitis [2]. Interestingly, while alcohol may sensitize the pancreas to damage by external and environmental factors such as genetics, high-fat diet, cigarette use, and infectious agents [3], relatively few people with alcohol use syndrome will develop pancreatitis (less than 5%). Heavy smokers who drink more than 400 g of alcohol per month are four times more likely to develop acute pancreatitis [2].  

Chronic alcohol consumption is the single most common cause of chronic pancreatitis, resulting in ~40% to 70% of all cases [4], and increases an individual's risk of developing pancreatic cancer [5]. Recurrent bouts of acute pancreatitis are associated with progression to chronic pancreatitis and are more common in chronic abusers of alcohol. Furthermore, most analyses suggest that some degree of chronic pancreatic injury already exists at the time of onset of an AP episode [2].  

The dose-response relationship between alcohol use and AP and CP is linear in men but non-linear for AP in women [6].

Epidemiology

Acute pancreatitis is the number one cause of gastrointestinal-related hospitalization in the United States and accounts for 2.6 billion dollars in healthcare spending and 279,000 annual admissions [7]. Eighty percent of these patients present with the mild, self-limited disease. Alcohol-related pancreatitis is more common in western countries and Japan. The annual incidence of acute pancreatitis is in the range of 13 to 45 per 100,000 people and chronic pancreatitis from 5 to 12 per 100,000 people. It is proportionally highest in males between 35 and 54 years old. The overall mortality is now about 2% and is usually associated with severe episodes of AP [8].

Pathophysiology

The complete pathophysiology of this disease is not entirely understood but likely results from alcohol’s effects on the small pancreatic ducts and acinar cells.  Alcohol is believed to cause precipitation and increases the viscosity of pancreatic secretions, which leads to the development of protein plugs in the small ducts [2], which then form calculi, causing progressive inflammation and fibrosis, which leads to loss of acinar, islet and ductal cells [9][2].

The pancreas uses oxidative and non-oxidative metabolism to process alcohol. The oxidative pathway leads to the formation of acetaldehyde, a reactive metabolite that causes detrimental effects in acinar cells through activation of stellate cells, increased expression of proinflammatory cytokines, and a decrease in NAD+/NADH ratios. The non-oxidative pathway requires the formation of fatty acid ethyl ester (FAEE) synthase, which leads to activation of key transcription factors, sustained increases in intracellular calcium, and inhibition of extracellular matrix proteins, ultimately leading to further cell injury [2].

Alcohol also leads to premature activation of trypsinogen and other digestive and lysosomal enzymes within the acinar cells themselves; this causes the pancreatic tissue to auto-digest and leads to further inflammation. Another contributing mechanism is intra-acinar activation of factor-kB (NF-kB), a transcriptional activator, which further drives the inflammatory response, which can cause up to 50% of pancreatic tissue damage and lead to severe, fatal inflammatory responses [3].

History and Physical

Alcohol-induced pancreatitis occurs in the setting of prolonged, chronic alcohol use, and its clinical features are similar to those of acute and chronic pancreatitis.

Symptoms

• Acute abdominal pain. Typically epigastric that radiates to the back.
  • Of note, pain may be less abrupt and poorly localized in alcoholic pancreatitis versus gallstone-induced AP.  
• Nausea or vomiting
• Anorexia
• Chronic pancreatitis may display the additional features of pancreatic insufficiency, including steatorrhea secondary to fat malabsorption and pancreatic diabetes secondary to endocrine cell destruction.

Examination

• May be normal
• Guarding
• Tenderness with peritonism
• Jaundice
• In severe cases, alcohol-induced pancreatitis may be classically associated with periumbilical or flank ecchymosis, also known as Cullen’s or Grey Turner’s signs respectively, and represent significant peritoneal or retroperitoneal hemorrhage.

Severe presentations of AP may include peritonitis, sepsis, acute respiratory distress syndrome (ARDS), and/or shock.

Evaluation

The diagnosis of acute pancreatitis requires that at least two of the following three criteria are met, based on the Revised Atlanta Classification system:

• Characteristic clinical features
• Laboratory evidence
• Imaging suggestive of pancreatitis

Clinical features include constant upper abdominal pain, with or without radiation to the back, and tenderness of the abdomen with palpation. Laboratory criteria include a serum lipase of at least three times the upper limit of normal.  Lipase peaks more rapidly, remains elevated for a more extended period, and has a higher sensitivity and specificity than amylase. Testing for both enzymes does not improve sensitivity or specificity.  A hepatic panel, calcium level, and triglyceride level may help differentiate alcoholic from other causes of AP. Finally, computerized tomography (CT) of abdomen with IV contrast is the imaging modality of choice and findings may include pancreatic enlargement, loss of pancreatic borders, surrounding fluid, and/or fat stranding. Areas of no enhancement indicate pancreatic necrosis. Imaging is normal in 15% to 30% of cases of mild pancreatitis and is not routinely indicated or needed for diagnosis. An exception to this rule is in cases where the patient does not respond to treatment after 48 hours, and further imaging can rule out other abdominal pathology or complications. Endoscopic retrograde cholangiopancreatography (ERCP) is not beneficial in alcohol-induced pancreatitis unless there are signs of comorbid biliary etiology [10].

Treatment / Management

Treatment follows the same principles as that for other causes of pancreatitis with the addition of alcohol cessation intervention during or after admission. Namely, these principles include [11][12][11]

• Timely diagnosis, preventing recurrence and avoiding and managing complications
• Intravenous fluid therapy
• Analgesics and antiemetics
• Electrolyte replacement
• Feeding
  • The current recommendations are also to initiate feeding trials within 24 hours of disease onset instead of keeping the patient nill per mouth (NPO).
  • There are no clear indications for the type of diet, but typically small low-fat, soft or solid meals correlate with shorter hospital stays than starting a clear liquid diet with slow advancement to solid meals.
  • Enteral feeds via a feeding tube are preferred to total parenteral nutrition in patients unable to tolerate PO.
• Involvement of intensive care for organ support if indicated

• The AGA currently recommends against the use of prophylactic antibiotics in predicted severe AP and necrotizing pancreatitis [13].

Additionally, providing brief alcohol intervention during admission or repeated counseling regularly at primary care or gastrointestinal clinic appointments has been shown to decrease alcohol use, hospital admissions for recurrent attacks, and the development of chronic pancreatitis [14].

Chronic pancreatitis pain can be managed with analgesics (avoiding high-potency opioids) and/or pancreatic enzyme replacement therapy. Antioxidants may be helpful in cases where other pharmaceutical options fail [12]. 

For those that medical therapy have failed, the following are options [9]

• Endoscopic therapy
  • Aims are to relieve obstruction through sphincterotomy, stenting, and dilation of strictures
  • Lithotripsy procedures
• Neurolysis
• Nerve block
• Surgery

Differential Diagnosis

The differential diagnoses include, but are not limited to:

• Pancreatitis secondary to other causes
• Gastritis or gastroenteritis
• Biliary disease secondary to obstructive or infectious pathology
• Bowel perforation or obstruction
• Nephrolithiasis
• Ectopic pregnancy
• Ischemic heart disease
• Pneumonia
• Aortic pathology

There is a broad differential diagnosis for this condition, as conditions affecting the gallbladder, stomach, or upper GI tract may present with a similar pain pattern. A history of frequent alcohol use, in combination with the characteristic abdominal pain patterns, elevated lipase, and imaging findings can help narrow down the differential.

Also, sickle cell crisis or diabetic ketoacidosis should also merit consideration in patients with a corresponding past medical history.

Staging

Many staging systems exist for prognostication of acute pancreatitis. Today the Atlanta classification is used to differentiate between acute and severe cases of acute pancreatitis, which includes the following:

• Presence of local complications- abscess, necrosis, or pseudocyst
• Evidence of organ injury (SBP less than 90, Cr more than 2, or GI bleeding more than 500 ml)
• Ranson score of 3 or greater or APACHE score of 8 or higher

Prognosis

Various scoring systems have been created to predict the severity of acute pancreatitis based on clinical, laboratory, and radiology findings; however, they have largely demonstrated low specificity and low positive predictive values. These include Ranson’s criteria, the APACHE II score, BISAP, and the CT severity index, among others. Further, the American Pancreatic Association and the American College of Gastroenterology differ in their criteria for prognosticating a severe disease course. While the number of hospital admissions for acute pancreatitis is increasing and 15% to 25% of cases categorize as severe acute pancreatitis, the mortality rate has significantly decreased to 1% to 2% throughout the last ten years. A recent report showed that following an initial episode of acute alcoholic pancreatitis, there was a 24% chance for a recurrent AP episode and a 16% chance of developing chronic pancreatitis [15].

Complications

Complications from this disease can have both localized and systemic effects, including:

• Acute peri-pancreatic fluid collection, seen as a homogenous fluid collection adjacent to the pancreas on CT imaging, usually beginning <4 weeks after symptoms onset.
• Pancreatic pseudocyst, seen as a walled-off fluid collection, usually arising >4 weeks from symptom onset.
• Necrotizing pancreatitis (5% to 10%), seen as an intra/extra-pancreatic heterogeneous fluid collection and necrosis
• Walled-off necrosis, seen as a heterogeneous collection of fluid and necrosis with a well-defined wall, usually occurring >4 weeks from symptom onset.

Systemic complications include sepsis, bacteremia from the migration of intestinal flora, pleural effusions, ARDS, and shock.

Chronic pancreatitis patients are also at increased risk of developing pancreatic cancer, pancreatic diabetes, bile duct obstruction, and splenic vein thrombosis.

Consultations

Consultations from the following specialties may be necessary:

• Gastroenterology
• General surgery
• Radiology
• Intensive care specialist
• Endocrinology
• Nutritionist
• Psychiatrist

Deterrence and Patient Education

As mentioned above, patients with acute pancreatitis or chronic pancreatitis secondary to alcohol use should receive brief alcohol intervention when admitted to the hospital or receive alcohol counseling during their primary care or gastroenterology outpatient visits.

Pearls and Other Issues

Alcohol use syndrome is one of the most common causes of both acute and chronic pancreatitis but likely requires other factors such as smoking and diet to manifest.

• Alcohol-induced pancreatitis likely results from alcohol causing increased, viscous secretions that block small pancreatic ducts and by premature activation of digestive and lysosomal enzymes within acinar cells.
• Diagnosis of AP requires meeting at least two of the following three criteria: characteristic clinical features, lipase levels three times the upper limit of normal, and/or imaging suggestive of pancreatitis.
• Treatment includes a combination of goal-directed fluid therapy, pain control, antiemetics, electrolyte replacement, early enteral nutrition, and alcohol cessation counseling.

Enhancing Healthcare Team Outcomes

Alcohol counseling has shown benefits to patients as it decreases total hospital admissions for acute pancreatitis. One randomized controlled trial showed that repeated counseling during gastroenterology clinic visits by an interprofessional team of physicians, physician assistants, nurse practitioners, and nurses decreases the risk of hospitalization for recurrent pancreatitis attacks. The team should report back to the team leader concerns or lack of patient compliance. Alcohol intervention strategies employed by clinicians and nurses have also significantly reduced alcohol consumption in men. Smoking cessation and dietary modifications are also recommendations, as these are risk factors when combined with alcohol. Reducing both alcohol and tobacco consumption was shown to reduce the risk of recurrent attacks, the progression to chronic pancreatitis, and the development of secondary pancreatic malignancy. [Level I] [14]

Patients with alcohol-induced pancreatitis usually need attention from many specialists, including pain specialists, dietitians, mental health nurses, and pharmacists. At each refill for medications, the pharmacist should educate the patient about the harms of alcohol and the importance of abstaining from this beverage. If the patient is non-compliant, the pharmacist should inform the clinician of concerns [16].

For patients with uncomplicated chronic pancreatitis, medical management remains the first line of therapy. Behavior modification counseling for the cessation of alcohol consumption and smoking is also in order; therefore, certified therapists play a large role in patient outcomes. [Level 2b] [17]

Since extraneous factors such as diet may play a synergistic role in leading to initial and recurrent episodes of pancreatitis, consultation with a nutritionist would benefit such patients. Patients should adhere to a low-fat diet and eat frequent small meals to decrease the stress on the pancreas. Endoscopic, surgical, or radiology-guided interventions may be required for cases of pancreatic pain refractory to medical therapy and conservative measures or used to treat the complications associated with acute pancreatitis such as pancreatic necrosis [13][16].