Sweat glands are appendages of the integument. There are eccrine and apocrine sweat glands. They differ in embryology, distribution, and function. Eccrine sweat glands are simple, coiled, tubular glands present throughout the body, most numerously on the soles of the feet. Thin skin covers most of the body and contains sweat glands, in addition to hair follicles, hair arrector muscles, and sebaceous glands. Exceptions are the vermillion border of the lips, external ear canal, nail beds, glans penis, clitoris, and labia minora, which do not contain sweat glands. The thick skin covering the palms of hands and soles of feet lack all skin appendages except sweat glands.
Apocrine sweat glands, also referred to as odoriferous sweat glands, are known for producing malodorous perspiration. They are large, branched glands that are mostly confined to the axillary and perineal regions, including the perianal region, labia majora in women, and the scrotum and prepuce in men. Apocrine sweat glands are also present in the nipples and areolar tissue surrounding the nipples.
Eccrine sweat glands serve a thermoregulatory function via evaporative heat loss. When the internal temperature of the body rises, sweat glands release water to the skin surface. There, it quickly evaporates, subsequently cooling the skin and blood beneath. This is the most effective means of thermoregulation in humans. Eccrine sweat glands also participate in ion and nitrogenous waste excretion. In response to emotional or thermal stimuli, sweat glands can produce at least 500 mL to 750 mL in a day.
Apocrine sweat glands start to function at puberty under the stimulation of sex hormones. They are associated with hair follicles in the groin and axillary region. The viscous, protein-rich product is initially odorless but may develop an odor after exposure to bacteria. Modified apocrine sweat glands include the wax-producing ceruminous glands of the external auditory meatus, the Moll glands found at the free margins of the eyelids, and the mammary glands of the breast.
Sweat glands play a regenerative role in skin damage. In second-degree cutaneous burns, which extend into the reticular dermis, regeneration of the epithelium occurs via skin appendages including hair follicles, sebaceous glands, and sweat glands. The epithelial cells surrounding these appendages produce more epithelial cells that progress to form a new epithelium, a process that can take 1 to 3 weeks.
Both eccrine and apocrine sweat glands originate from the epidermis. Eccrine glands begin as epithelial cellular buds that grow into the underlying mesenchyme. The glandular secretory components are then formed by elongation of the gland and coiling of the ends. Primordial sweat ducts are formed by epithelial attachments of the developing gland. Finally, the central cells degenerate to form the lumen of the sweat duct. Cells on the periphery of the gland differentiate into secretory and myoepithelial cells. Myoepithelial cells are thought to be specialized smooth muscle cells that function to expel sweat from the gland. Eccrine sweat glands first appear on the palms and soles during the fourth month of gestation; they become functional soon after birth.
On the other hand, apocrine sweat glands do not function until hormonal stimulation during puberty, and their ducts do not open onto the skin surface. This is because these glands originate from the stratum germinativum of the epidermis. Therefore, down-growth does not produce a duct open to the skin surface. Instead, the ducts open into hair follicles and sweat is released through the hair opening in the skin. The canals of these apocrine sweat gland ducts enter the hair follicle superficial to the sebaceous gland, which results in a protein-rich sweat rather than the watery sweat associated with eccrine sweat glands.
Sweat glands along with all other skin appendages receive blood supply from cutaneous perforators of underlying source vessels. The perforators may branch directly from the source as septocutaneous or fasciocutaneous perforators or from muscular branches as musculocutaneous perforators. Once these perforators reach the skin, they form extensive networks called dermal and subdermal plexuses. Interconnections between these plexuses form via connecting vessels that run perpendicular to the skin surface, forming a continuous vascular plexus in the skin.
Lymphatic drainage parallels the blood supply, starting with blind-ended lymphatic capillaries in the dermal papillae. These drain into dermal and deep dermal plexuses that eventually coalesce to form larger lymphatic vessels.
Eccrine sweat glands receive sympathetic innervation via cholinergic fibers that send impulses in response to changes in core body temperature. Sympathetic innervation to the sweat glands is mediated by the thermoregulatory center of the hypothalamus. A short preganglionic cholinergic fiber is originating from the thoracolumbar region of the spinal cord synapses with the postganglionic neuron via nicotinic acetylcholine. The postganglionic fiber releases acetylcholine, which differs from all other sympathetic postganglionic fibers that release norepinephrine. Cholinergic stimulation of muscarinic receptors induces sweating. Apocrine sweat glands receive adrenergic sympathetic innervation. Because apocrine sweat glands respond to norepinephrine, they are involved in emotional sweating due to stress, fear, pain, and sexual stimulation.
Given the role of sweat glands in thermoregulation, both eccrine and apocrine glands are associated with various diseases ranging from mild and discomforting to life-threatening. Disorders of sweating can have emotional, social, and professional implications.
Hyperhydrosis is the excessive excretion of sweat above the quantity needed for thermoregulation. It can be idiopathic or due to another endocrine, neurologic, or infectious disorders. Treatment options include topical medications, oral medications, surgical procedures, or botulinum toxin injection. Bromhidrosis is a similar disorder that presents with excessive malodorous perspiration. It can involve either apocrine or eccrine sweat glands; apocrine bromhidrosis tends to develop after puberty, while eccrine bromhidrosis may develop at any age. It is caused by excessive perspiration that secondarily becomes malodorous by bacterial breakdown. Because poor hygiene most often aggravates bromhidrosis, an effective treatment is improving personal hygiene. Surgical approaches, antibacterial agents, and antiperspirants are treatment options as well.
The sweat glands of patients with cystic fibrosis (CF) are ineffective at reabsorbing salt which has major implications. CF is an autosomal recessive congenital disease in which the cystic fibrosis transmembrane regulator (CFTR) that normally inhabits the apical membrane of epithelial cells is defective. CFTR is a transmembrane protein that functions as part of a cAMP-regulated chloride ion channel; in normal sweat glands, the ductal epithelium reabsorbs sodium and chloride ions in response to aldosterone so that sweat is hypotonic. In CF patients, the sweat glands fail to reabsorb chloride which affects sodium reabsorption resulting in salty sweat and an inability of sweat glands to participate in ion regulation. Disruption of the same membrane proteins in the respiratory and gastrointestinal epithelium result in accumulations of thick mucus.
Another autosomal recessive congenital disorder that affects sweat glands is lamellar ichthyosis. Infants present with persistent scaling skin and growth of hair may be curtailed. Impairment of sweat gland development often causes infants to suffer in severely hot weather as they cannot maintain thermoregulation through sweating.
Hidradenitis suppurativa is a chronic, inflammatory disease affecting the hair follicles. This ailment has classically been associated with the apocrine sweat glands as it manifests after puberty in the apocrine-gland concentrated areas of the body. However, the pathophysiology involves follicular occlusion rather than an apocrine disorder as previously thought. Patients often present with tender, suppurative subcutaneous nodules and abscesses in the axillae and groin. The lesions can form sinus tracts and extensive scarring.
Hypohydrotic ectodermal dysplasia is a disease characterized by hypotrichosis (decreased growth of scalp and body hair), hypodontia (congenital absence of teeth), and hypohidrosis. The term “hypohidrotic” indicates impairment in the ability to perspire. Patients born with hipohydrotic ectodermal dysplasia have difficulty regulating body temperature and therefore must learn to modify their environment in order to control exposure to heat.
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