Traumatic brain injury (TBI) is a common presentation in emergency departments, which accounts for more than one million visits annually. It is a common cause of death and disability among children and adults.
Based on the Glasgow Coma Scale (GCS) score, it is classified as:
Based on the mechanism, head trauma is classified as (1) blunt (most common mechanism), (2) penetrating (most fatal injuries), (3) blast.
Most severe TBIs result from motor vehicle collisions and falls.
The following concepts are involved in the regulation of blood flow and should be considered.
1) Monroe-Kellie Doctrine
2) Regulation of Cerebral Blood Flow (CBF) (Autoregulation)
3) Cerebral Perfusion Pressure (CPP)
4) Mean arterial pressure (MAP)
5) Intracranial pressure (ICP)
TBI can be classified as primary injury and secondary injury:
Primary injury includes injury upon initial impact that causes displacement of the brain due to direct impact, rapid acceleration-deceleration, or penetration. These injuries may cause contusions, hematomas, or axonal injuries.
Secondary Injury/Secondary Neurotoxic Cascade
Secondary injury consists of the changes that occur after the initial insult. It can be due to:
After a primary brain injury, a cascade of cellular and biochemical events occurs which include the release of glutamate into the presynaptic space resulting in activation of N-methyl-D-aspartate, a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, and other receptors. This ionic shift may activate cytoplasmic and nuclear enzymes, resulting in mitochondrial damage, and cell death and necrosis.
Herniation occurs due to increased ICP. Following are the types of herniations.
1) Uncal transtentorial
2) Central transtentorial
3) Cerebellar tonsillar
4) Upward posterior fossa/cerebellar herniation
A good history concerning the mechanism of injury is important. Follow trauma life support protocol and perform primary, secondary, and tertiary surveys. Once the patient is stabilized, a neurologic examination should be conducted. CT scan is the diagnostic modality of choice in the initial evaluation of patients with head trauma.
CT scan is required in patients with head trauma
It is important to understand that no individual history and physical examination finding can eliminate the possibility of intracranial injury in head trauma patients.
New Orleans Criteria
Canadian CT Head Rule
Level A Recommendation
With the loss of consciousness or posttraumatic amnesia only if one or more of the following symptoms are present:
Level B Recommendation
Without loss of consciousness or posttraumatic amnesia if one of the following specific symptoms presents:
The risk of intracranial injury when clinical decision rule results are negative is less than 1%.
For children, Pediatric Emergency Care Applied Research Network (PECARN) decision rules exist to rule out the presence of clinically important traumatic brain injuries. However, this rule applies only to children with GCS > 14.
The most important goal is to prevent secondary brain injuries. This can be achieved by the following:
A relatively higher systemic blood pressure is needed:
Airway and Breathing
Identify any condition which might compromise airway, such as pneumothorax.
For sedation, consider using short-acting agents having minimal effect on blood pressure or ICP:
Consider endotracheal intubation in the following situations:
The cervical spine should be maintained in-line during intubation.
Nasotracheal intubation should be avoided in patients with facial trauma or basilar skull fracture.
Avoid hypotension. A normal blood pressure may not be adequate to maintain adequate flow and CPP if ICP is elevated.
Isolated head trauma usually does not cause hypotension. Look for another cause if the patient is in shock.
Increased ICP can occur in head trauma patients resulting in the mass occupying lesion. Utilize a team approach to manage impending herniation.
Signs and symptoms:
CT scan findings:
Head Position: Raise the head of the bed and maintain the head in midline position at 30 degrees: potential to improve cerebral blood flow by improving cerebral venous drainage.
Lower cerebral blood volume (CBV) can lower ICP.
Temperature Control: Fever should be avoided as it increases cerebral metabolic demand and affects ICP.
Seizure prophylaxis: Seizures should be avoided as they can also worsen CNS injury by increasing the metabolic requirement and may potentially increase ICP. Consider administering fosphenytoin at a loading dose of 20mg/kg.
Only use an anticonvulsant when it is necessary, as it may inhibit brain recovery.
Fluid management: The goal is to achieve euvolemia. This will help to maintain adequate cerebral perfusion. Hypovolemia in head trauma patients is harmful. Isotonic fluid such as normal saline or Ringer Lactate should be used. Also, avoid hypotonic fluid.
Sedation: Consider sedation as agitation and muscular activity may increase ICP.
Normocarbia is desired in most head trauma patients. The goal is to maintain PaCO between 35-45 mmHg. Judicious hyperventilation helps to reduce PaCO2 and causes cerebral vasoconstriction. Beware that, if extreme, it may reduce CPP to the point that exacerbation of secondary brain injury may occur. Avoid hypercarbia: PaCO > 45 may cause vasodilatation and increases ICP.
A potent osmotic diuretic with net intravascular volume loss
Reduces ICP and improves cerebral blood flow, CPP, and brain metabolism
Expands plasma volume and can improve oxygen-carrying capacity
Onset of action is within 30 minutes
Duration of action is from two to eight hours
Dose is 0.25-1 g/kg (maximum: 4 g/kg/day)
Avoid serum sodium > 145 m Eq/L
Relative contraindication: hypotension does not lower ICP in hypovolemic patients.
May be used in hypotensive patients or patients who are not adequately resuscitated.
Dose is 250 mL over 30 minutes.
Serum osmolality and serum sodium should be monitored.
Mild Head Trauma
The majority of head trauma is mild. These patients can be discharged following a normal neurological examination as there is minimal risk of developing an intracranial lesion.
Consider observing at least 4 to 6 hours if no imaging was obtained.
Consider hospitalization if these other risk factors are present:
Provide strict return precautions for patients discharged without imaging.
Hyperglycemia may worsen the outcome.
An elevated temperature may increase ICP and worsen outcome.
A prolonged seizure may worsen secondary brain injuries.
Head trauma is a major public health problem accounting for thousands of admissions each year and costing the healthcare system billions of dollars. The majority of patients with head trauma are seen in the emergency department and is often associated with other organ injuries as well. The care of a patient with head trauma is multidisciplinary as almost every organ system is affected. Most patients require admission and monitoring in an ICU setting. The outcome of these patients depends on the severity of the head trauma, initial GCS score, and any other organ injury. Data indicates that those patients with an initial GCS of 8 or less have a mortality rate of 30% within 2 weeks of the injury. Other negative prognostic factors include advanced age, elevated intracranial pressure, and presence of a gross neurologic deficit on presentation. Patients with a GCS less than 9 often require mechanical ventilation, tracheostomy, and a feeding tube. With prolonged hospital stay, there are prone to pressure ulcers, aspiration, sepsis, failure to thrive and deep vein thrombus. Recovery in most patients can take months or even years. Even those who are discharged often have residual deficits in executive function or neurological deficits. Despite education of the public, many young people still lead a lifestyle that predisposes them to head injury. Young people still drink and drive, text while driving, abuse alcohol and illicit drugs, and are often involved in high-risk sporting activities, which makes them susceptible to head trauma.
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