[1]
Halford GM, Lordkipanidzé M, Watson SP. 50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams. Platelets. 2012:23(6):415-22. doi: 10.3109/09537104.2011.632032. Epub 2011 Nov 18
[PubMed PMID: 22098129]
Level 3 (low-level) evidence
[2]
Konstan MW, VanDevanter DR, Sawicki GS, Pasta DJ, Foreman AJ, Neiman EA, Morgan WJ. Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis. Annals of the American Thoracic Society. 2018 Apr:15(4):485-493. doi: 10.1513/AnnalsATS.201706-486OC. Epub
[PubMed PMID: 29313709]
[3]
Sheridan DC,Hendrickson RG,Lin AL,Fu R,Horowitz BZ, Adolescent Suicidal Ingestion: National Trends Over a Decade. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. 2017 Feb
[PubMed PMID: 27889404]
[4]
Perry SJ,Streete PJ,Volans GN, Ibuprofen overdose: the first two years of over-the-counter sales. Human toxicology. 1987 Mar
[PubMed PMID: 3557476]
[5]
Gummin DD, Mowry JB, Spyker DA, Brooks DE, Fraser MO, Banner W. 2016 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 34th Annual Report. Clinical toxicology (Philadelphia, Pa.). 2017 Dec:55(10):1072-1252. doi: 10.1080/15563650.2017.1388087. Epub 2017 Nov 29
[PubMed PMID: 29185815]
[6]
Davies NM. Clinical pharmacokinetics of ibuprofen. The first 30 years. Clinical pharmacokinetics. 1998 Feb:34(2):101-54
[PubMed PMID: 9515184]
[7]
Kauffman RE, Nelson MV. Effect of age on ibuprofen pharmacokinetics and antipyretic response. The Journal of pediatrics. 1992 Dec:121(6):969-73
[PubMed PMID: 1447669]
[8]
Section on Clinical Pharmacology and Therapeutics, Committee on Drugs, Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics. 2011 Mar:127(3):580-7. doi: 10.1542/peds.2010-3852. Epub 2011 Feb 28
[PubMed PMID: 21357332]
[9]
Antal EJ, Wright CE 3rd, Brown BL, Albert KS, Aman LC, Levin NW. The influence of hemodialysis on the pharmacokinetics of ibuprofen and its major metabolites. Journal of clinical pharmacology. 1986 Mar:26(3):184-90
[PubMed PMID: 3958223]
[10]
Wanwimolruk S, Brooks PM, Birkett DJ. Protein binding of non-steroidal anti-inflammatory drugs in plasma and synovial fluid of arthritic patients. British journal of clinical pharmacology. 1983 Jan:15(1):91-4
[PubMed PMID: 6849750]
[11]
Hall AH, Smolinske SC, Conrad FL, Wruk KM, Kulig KW, Dwelle TL, Rumack BH. Ibuprofen overdose: 126 cases. Annals of emergency medicine. 1986 Nov:15(11):1308-13
[PubMed PMID: 3777588]
Level 3 (low-level) evidence
[12]
Volans G, Monaghan J, Colbridge M. Ibuprofen overdose. International journal of clinical practice. Supplement. 2003 Apr:(135):54-60
[PubMed PMID: 12723749]
[13]
Kimmey MB, Silverstein FE, Saunders DR, Chapman RC. Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine. Digestive diseases and sciences. 1987 Aug:32(8):851-6
[PubMed PMID: 3301232]
[14]
Marciniak KE, Thomas IH, Brogan TV, Roberts JS, Czaja A, Mazor SS. Massive ibuprofen overdose requiring extracorporeal membrane oxygenation for cardiovascular support. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2007 Mar:8(2):180-2
[PubMed PMID: 17273120]
[15]
Lee CY, Finkler A. Acute intoxication due to ibuprofen overdose. Archives of pathology & laboratory medicine. 1986 Aug:110(8):747-9
[PubMed PMID: 3755329]
[16]
Clarke SF, Arepalli N, Armstrong C, Dargan PI. Duodenal perforation after ibuprofen overdose. Journal of toxicology. Clinical toxicology. 2004:42(7):983-5
[PubMed PMID: 15641644]
[17]
Whelton A, Stout RL, Spilman PS, Klassen DK. Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison. Annals of internal medicine. 1990 Apr 15:112(8):568-76
[PubMed PMID: 2183665]
Level 1 (high-level) evidence
[18]
Murray MD, Brater DC. Adverse effects of nonsteroidal anti-inflammatory drugs on renal function. Annals of internal medicine. 1990 Apr 15:112(8):559-60
[PubMed PMID: 2327675]
[19]
Kim J, Gazarian M, Verjee Z, Johnson D. Acute renal insufficiency in ibuprofen overdose. Pediatric emergency care. 1995 Apr:11(2):107-8
[PubMed PMID: 7596869]
[20]
Hall AH, Smolinske SC, Stover B, Conrad FL, Rumack BH. Ibuprofen overdose in adults. Journal of toxicology. Clinical toxicology. 1992:30(1):23-37
[PubMed PMID: 1542147]
[21]
Court H, Volans GN. Poisoning after overdose with non-steroidal anti-inflammatory drugs. Adverse drug reactions and acute poisoning reviews. 1984 Spring:3(1):1-21
[PubMed PMID: 6541425]
[22]
Mattana J, Perinbasekar S, Brod-Miller C. Near-fatal but reversible acute renal failure after massive ibuprofen ingestion. The American journal of the medical sciences. 1997 Feb:313(2):117-9
[PubMed PMID: 9030680]
[23]
McElwee NE, Veltri JC, Bradford DC, Rollins DE. A prospective, population-based study of acute ibuprofen overdose: complications are rare and routine serum levels not warranted. Annals of emergency medicine. 1990 Jun:19(6):657-62
[PubMed PMID: 2188537]
[24]
Chelluri L, Jastremski MS. Coma caused by ibuprofen overdose. Critical care medicine. 1986 Dec:14(12):1078-9
[PubMed PMID: 3780253]
[25]
Oker EE, Hermann L, Baum CR, Fentzke KM, Sigg T, Leikin JB. Serious toxicity in a young child due to ibuprofen. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2000 Jul:7(7):821-3
[PubMed PMID: 10917334]
[26]
Easley RB, Altemeier WA 3rd. Central nervous system manifestations of an ibuprofen overdose reversed by naloxone. Pediatric emergency care. 2000 Feb:16(1):39-41
[PubMed PMID: 10698143]
[27]
Holubek W, Stolbach A, Nurok S, Lopez O, Wetter A, Nelson L. A report of two deaths from massive ibuprofen ingestion. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2007 Jun:3(2):52-5
[PubMed PMID: 18072160]
[28]
Zuckerman GB, Uy CC. Shock, metabolic acidosis, and coma following ibuprofen overdose in a child. The Annals of pharmacotherapy. 1995 Sep:29(9):869-71
[PubMed PMID: 8547735]
[29]
Page CB, Wilson PA, Foy A, Downes MA, Whyte IM, Isbister GK. Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis. The Medical journal of Australia. 2011 Jun 6:194(11):614
[PubMed PMID: 21644884]
[30]
Levine M, Khurana A, Ruha AM. Polyuria, acidosis, and coma following massive ibuprofen ingestion. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2010 Sep:6(3):315-7. doi: 10.1007/s13181-010-0076-8. Epub
[PubMed PMID: 20419362]
[31]
Jain S. Ibuprofen-induced thrombocytopenia. The British journal of clinical practice. 1994 Jan-Feb:48(1):51
[PubMed PMID: 8179987]
[32]
Seifert SA, Bronstein AC, McGuire T. Massive ibuprofen ingestion with survival. Journal of toxicology. Clinical toxicology. 2000:38(1):55-7
[PubMed PMID: 10696926]
[33]
Meyer T, Herrmann C, Wiegand V, Mathias B, Kiefel V, Mueller-Eckhardt C. Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration. The Clinical investigator. 1993 May:71(5):413-5
[PubMed PMID: 8508012]
[34]
Benmoussa J, Chevenon M, Nandi M, Forlenza TJ, Nfonoyim J. Ibuprofen-induced thrombotic thrombocytopenic purpura. The American journal of emergency medicine. 2016 May:34(5):942.e5-7. doi: 10.1016/j.ajem.2015.10.044. Epub 2015 Oct 26
[PubMed PMID: 26643158]
[36]
Soos A. [Thrombocytopenic purpura caused by ibuprofen]. Ugeskrift for laeger. 1979 Oct 15:141(42):2901
[PubMed PMID: 574324]
[37]
Catizone L, Santoro A, Scialfa G, Cagnoli L, Fabbri L. [Thrombotic thrombocytopenic purpura due to administration of Ibuprofen]. Minerva nefrologica. 1974 Nov-Dec:21(6):439-44
[PubMed PMID: 4477894]
[38]
Vogts N, Young S. Pulmonary infiltrates with eosinophilia syndrome in ibuprofen overdose. The New Zealand medical journal. 2012 Aug 24:125(1360):74-5
[PubMed PMID: 22932657]
[39]
Lindblad R, Rödjer S. A case of severe pancytopenia caused by ibuprofen. Journal of internal medicine. 1991 Mar:229(3):281-3
[PubMed PMID: 2007846]
Level 3 (low-level) evidence
[40]
Lapatto-Reiniluoto O, Kivistö KT, Neuvonen PJ. Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram. British journal of clinical pharmacology. 1999 Aug:48(2):148-53
[PubMed PMID: 10417490]
[41]
Richy F, Bruyere O, Ethgen O, Rabenda V, Bouvenot G, Audran M, Herrero-Beaumont G, Moore A, Eliakim R, Haim M, Reginster JY. Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Annals of the rheumatic diseases. 2004 Jul:63(7):759-66
[PubMed PMID: 15194568]
Level 3 (low-level) evidence
[42]
Gummin DD, Mowry JB, Beuhler MC, Spyker DA, Rivers LJ, Feldman R, Brown K, Pham NPT, Bronstein AC, DesLauriers C. 2022 Annual Report of the National Poison Data System(®) (NPDS) from America's Poison Centers(®): 40th Annual Report. Clinical toxicology (Philadelphia, Pa.). 2023 Oct:61(10):717-939. doi: 10.1080/15563650.2023.2268981. Epub 2023 Dec 12
[PubMed PMID: 38084513]
[43]
Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arteriosclerosis, thrombosis, and vascular biology. 2011 May:31(5):986-1000. doi: 10.1161/ATVBAHA.110.207449. Epub
[PubMed PMID: 21508345]