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Cutaneous Angiofibroma

Editor: Laura S. Tanner Updated: 9/12/2022 9:14:31 PM

Cutaneous angiofibroma is a term used to define a group of lesions with different clinical presentations but with the same histologic findings. They are benign fibrous neoplasms comprised of a proliferation of stellate and spindled cells, thin-walled blood vessels with dilated lumina in the dermis, and concentric collagen bundles. Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas.  Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.[1][2][3]


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TS is caused by mutations in the genes tuberous sclerosis complex 1 (TSC 1) that encodes the protein hamartin and tuberous sclerosis complex 2 (TSC 2) that encodes the protein tuberin. MEN-1 is due to a mutation in the MEN1 gene which encodes menin. Birt-Hogg-Dube syndrome is caused by a mutation in the FLCN gene which encodes folliculin.

Seventy-five percent of individuals with TS will eventually develop angiofibromas. Periungual angiofibromas are less common in children, but the incidence increases to 40% in adults. In TS, periungual angiofibromas occur in 30% to 60% of patients. Oral fibromas can occur in 30% to 70% of patients with TS and occur more in adults than in children. Pearly penile papules occur in about 30% of post-pubertal males.

As mentioned above TS is caused by mutations in TSC 1 which encodes the protein hamartin and TSC 2 which encodes the protein tuberin. These proteins normally suppress the activation of mammalian target of rapamycin (mTOR), however, when mutated, they cause unregulated proliferation of cell growth forming multi-organ hamartomas. mTOR is activated in the proliferating fibroblast-like cells within facial angiofibromas. The cells produce an epidermal growth factor called epiregulin, which stimulates epidermal cell proliferation so that they are produced at a faster rate. Angiofibromas of TS also have vascular proliferation from increased expression of angiogenic factors such as vascular endothelial growth factor (VEGF). VEGF stimulates mTOR.[4][5][6]

All cutaneous angiofibromas are composed of a dermal proliferation of fibroblasts in a collagenous stroma with an increase in the number of thin-walled, dilated blood vessels. Collagen fibers are concentrically arranged around hair follicles and blood vessels. Elastic fibers can be decreased, and the epidermis can be atrophic. Fibroblasts can be stellate in shape and can be multinucleated. Immunohistochemistry for these cells will show positivity for factor XIIa and negative for S100 protein.

History and Physical

Fibrous papules are solitary, dome-shaped, skin-colored to red papules located on the central face, usually around the nose and on the malar eminences. They can have tiny telangiectatic vessels located on the surface of the papule. In TS, angiofibromas typically arise symmetrically on the cheeks, nasolabial folds, nose, and chin. They can start off as erythematous macules that form into the red to red-brown papules that can coalesce into plaques.

Pearly penile papules are pearly, white, dome-shaped, closely aggregated small papules located on the glans penis in a multilayered and circumferential manner on the corona.

Periungual angiofibromas begin to occur in TS in late childhood to early adulthood. They arise from the lateral or proximal nail fold and more commonly occur on the toes. They can be painful and can distort the shape of the nail.

Oral fibromas occur most commonly on the gingiva, but lesions can also occur on buccal or labial mucosa and occasionally the tongue.

Clinical findings in Birt-Hogg-Dube include fibrofolliculomas, perifollicular fibromas (some authorities consider perifollicular fibroma to be related to angiofibroma), and trichodiscomas. These are all present as skin colored to hypopigmented papules on the head and neck or upper trunk.


The diagnosis of angiofibroma is made by history, physical exam, and skin biopsy. If TS, MEN-1, or Birt-Hogg-Dube are suspected, genetic testing should be completed as well as an extensive workup searching for tumors for their respected conditions.

Treatment / Management

Current treatments for angiofibromas include shave excision, cryotherapy, electrodessication, radiofrequency ablation, dermabrasion, lasers such as ablative fractional laser resurfacing (AFR) and pulsed dye laser (PDL), and topical podophyllotoxin. Although these treatments have proven to be successful, they can result in scarring, post-inflammatory hyperpigmentation, and pain. The recurrence rate can be up to 80%, necessitating follow-up treatments. Topical rapamycin, a mTOR inhibitor, seems to be a safe and effective treatment for angiofibromas however long-term studies still need to be conducted.  Combination treatments, such as fractional laser resurfacing and PDL laser, can be employed with topical medications, such as timolol or rapamycin, to effectively treat these lesions.[7][8][9]

Rapamycin has recently gained popularity in the treatment of angiofibromas. After binding to mTOR, it inhibits its activity which downregulates cell proliferation. It also decreases VEGF production by downregulating VEGF- stimulated endothelial cell proliferation (Habib). Several case series, case reports, and one randomized controlled trial have been published verifying the effectiveness of topical rapamycin used as .1% once or twice daily, as well as .2%, used 5 times a week and .4% used 3 times a week. The angiofibromas cleared as long as the medication was being used. The longest reported follow up has been 3 years. Many have used crushed rapamycin tablets and mixed them in Vaseline to obtain the desired concentration which was not a standardized dose. DeKlotz et al. proposed a standardized formulation on how to make .1% topical rapamycin in 2011. Few if any side effects occur from the topical medication including mild irritation and erythema. Park et al. showed that topical rapamycin was enough to treat the lesions when they were small in size, that is less than 4 mm. However, if they were larger than 4 mm, ablative resurfacing was needed in conjunction with rapamycin. It can also be costly to use topical rapamycin in the treatment of angiofibromas due to the length of treatment that is necessary to obtain sufficient results costing several hundred to several thousand dollars out of pocket.

Beta-blockers have been used for many years now in the treatment of vascular lesions. Oral propranolol has been successful in the treatment of hemangiomas in the pediatric population. However, side effects such as hypoglycemia limit its use in certain patients. Topical timolol .5% solution or gel used 2 or 3 times a day has proven to be very successful in the treatment of superficial hemangiomas. The mechanism of action of beta-blockers is thought to be due to its role in blocking the formation of renin to angiotensin II. In doing so, angiotensin II does not form VEGF, which converts endothelial stem cells to endothelial cells, leading to decreased capillary development. Matrix metalloproteinase-9 is involved in angiogenesis, and its activity is thought to be inhibited by beta blockers. One other way beta- blockers work to decrease angiogenesis is by producing osteoprotegerin. This causes tumor necrosis factor apoptosis of mesenchymal and endothelial cells.[10][11]

Differential Diagnosis

For lesions on the face, angiofibromas can be confused with acne, acrochordons, intradermal melanocytic nevi, basal cell carcinoma, and adnexal tumors. Periungual angiofibroma can look similar to verruca vulgaris and subungual exostosis. Pearly penile papules can be confused with condyloma acuminatum and molluscum contagiosum.


Angiofibromas are benign prolifferations however they do not spontaneous improve and, when multiple, can cause significant disfigurement, bleeding, pruritus, and erythema emanating the need for an effective treatment.  

Enhancing Healthcare Team Outcomes

Cutaneous angiofibromas are managed by an interprofessional team. Current treatments for angiofibromas include shave excision, cryotherapy, electrodessication, radiofrequency ablation, dermabrasion, lasers such as ablative fractional laser resurfacing (AFR) and pulsed dye laser (PDL), and topical podophyllotoxin. Although these treatments have proven to be successful, they can result in scarring, post-inflammatory hyperpigmentation, and pain. The recurrence rate can be up to 80%, necessitating follow-up treatments. Topical rapamycin, a mTOR inhibitor, seems to be a safe and effective treatment for angiofibromas however long-term studies still need to be conducted.  Combination treatments, such as fractional laser resurfacing and PDL laser, can be employed with topical medications, such as timolol or rapamycin, to effectively treat these lesions. Because the lesions are benign, they should only be removed for cosmesis or compression on adjacent structures resulting in pain. (Level V)


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<p>Tuberous Sclerosis Angiofibromas</p>

Tuberous Sclerosis Angiofibromas

Source: DermNet



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Kundu GK,Ahmed S,Akhter S,Islam MT,Dwa T,Sabbir AM, Clinical and Neuro-radiological Presentation of Tuberous Sclerosis Complex in Tertiary Care Centre. Mymensingh medical journal : MMJ. 2018 Jan;     [PubMed PMID: 29459606]


Wang S,Liu Y,Wei J,Zhang J,Wang Z,Xu Z, Tuberous Sclerosis Complex in 29 Children: Clinical and Genetic Analysis and Facial Angiofibroma Responses to Topical Sirolimus. Pediatric dermatology. 2017 Sep;     [PubMed PMID: 28771801]


Garcia NG,de Carli ML,Oliveira DT,Soares CT,Ribeiro Júnior NV,Sperandio FF,Hanemann JA, Tuberous Sclerosis with Severe Cutaneous Manifestation and Multiples Facial Angiofibromas. Head and neck pathology. 2016 Dec;     [PubMed PMID: 27140177]


DiCicco B,Johnson W,Allred J,Soldano AC,Ramsdell WM, Koenen's tumor and facial angiofibromas in a case of Birt-Hogg-Dubé syndrome: A cutaneous contribution to growing evidence of a relationship with tuberous sclerosis complex. JAAD case reports. 2016 May;     [PubMed PMID: 27274535]

Level 3 (low-level) evidence


Bouguéon G,Lagarce F,Martin L,Pailhoriès H,Bastiat G,Vrignaud S, Formulation and characterization of a 0.1% rapamycin cream for the treatment of Tuberous Sclerosis Complex-related angiofibromas. International journal of pharmaceutics. 2016 Jul 25;     [PubMed PMID: 27260135]


Salomon FF,Barreto MM,Zanetti G,Rodrigues RS,Gasparetto EL,Marchiori E, CNS and cutaneous involvement in tuberous sclerosis complex. Arquivos de neuro-psiquiatria. 2015 Sep;     [PubMed PMID: 26352504]


Wataya-Kaneda M,Tanaka M,Yang L,Yang F,Tsuruta D,Nakamura A,Matsumoto S,Hamasaki T,Tanemura A,Katayama I, Clinical and Histologic Analysis of the Efficacy of Topical Rapamycin Therapy Against Hypomelanotic Macules in Tuberous Sclerosis Complex. JAMA dermatology. 2015 Jul;     [PubMed PMID: 25692384]


Ma G,Wu P,Lin X,Chen H,Li W,Hu X,Jin Y, Nd:YAG laser for     [PubMed PMID: 24602020]


Park J,Yun SK,Cho YS,Song KH,Kim HU, Treatment of angiofibromas in tuberous sclerosis complex: the effect of topical rapamycin and concomitant laser therapy. Dermatology (Basel, Switzerland). 2014;     [PubMed PMID: 24401865]


Patel AM,Chou EL,Findeiss L,Kelly KM, The horizon for treating cutaneous vascular lesions. Seminars in cutaneous medicine and surgery. 2012 Jun;     [PubMed PMID: 22640429]