21-Hydroxylase Deficiency


4.6 out of 5 (74 Reviews)



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Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

60 Minutes

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Activity Description

21-hydroxylase deficiency is an autosomal recessive disorder caused by a deficiency in one of the enzymes required for the synthesis of cortisol in the adrenal glands. 21-Hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia but can be a challenge to diagnose and treat. This activity reviews the use of glucocorticoid and mineralocorticoid replacement as the mainstays of treatment and highlights the role of a well-coordinated interprofessional care team in improving outcomes for patients with congenital adrenal hyperplasia.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Review the pathophysiologic basis of 21-hydroxylase deficiency.
  • Describe the expected history and physical findings for a patient with 21-hydroxylase deficiency.
  • Outline the recommended screening tests to evaluate for 21-hydroxylase deficiency.
  • Summarize the need for an interprofessional team approach to caring for a patient with 21-hydroxylase deficiency.


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COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Anesthesiology
  • Pediatric Anesthesia
American Board of Internal Medicine
  • Adolescent Medicine
  • Endocrinology, Diabetes, and Metabolism
  • Internal Medicine
American Board of Otolaryngology
  • Pediatric Otolaryngology
American Board of Pathology
  • Endocrine
American Board of Pediatrics
  • General Pediatrics
  • Pediatric Endocrinology

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  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


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The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

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  • Name: 'Fig.1 Pathways of steroid biosynthesis in the adrenal cortex..JPG' Attribution: Contributed by Research Gate


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Richard P. on 6/20/2022

Its good.every single word is to the point.consised all imp points are covered

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Reagan P. on 12/29/2022

I paid for this. Should be able to do more testing for my AANP.

Holly R. on 1/16/2023

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Marcie R. on 3/13/2023

More pediatric urology topics needed

Clare C. on 3/25/2023

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