4.7 out of 5 (28 Reviews)



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Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

60 Minutes

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Activity Description

Alprostadil is a medication used in the management and treatment of erectile dysfunction in males and for temporary patency of ductus arteriosus in newborns with congenital heart diseases before surgical intervention. It is in the prostaglandin analog class of medications. This activity reviews the indications, action, and contraindications for alprostadil as a valuable agent in the therapy of erectile dysfunction in males and presurgical management for newborns with congenital heart diseases with ductus arteriosus dependent circulation. This activity will also highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, monitoring, relevant interactions) pertinent for members of the interprofessional team in the management of those conditions.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Review the indications for alprostadil.
  • Describe the adverse effects and contraindications of alprostadil.
  • Identify the appropriate monitoring and toxicity of alprostadil.
  • Summarize interprofessional team strategies for enhancing care coordination and communication to advance the management of conditions that can be treated with alprostadil and improve patient outcomes.


StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Internal Medicine
  • Adolescent Medicine
  • Cardiovascular Disease
  • Geriatric Medicine
  • Internal Medicine
American Board of Pathology
  • Cardiovascular
  • Clinical Pathology
  • Male Genital

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


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