4.8 out of 5 (26 Reviews)



Post Assessment Questions


Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

60 Minutes

Need Help?  If you have a system or content concerns, please contact support@statpearls.com

Activity Description

Zolmitriptan is a medication used in the management and treatment of acute migraines. It is in the triptan class of drugs. Migraines are due to local cranial vasodilatation and the release of neuropeptides (calcitonin gene-related peptide, vasoactive intestinal peptide (VIP), and substance P) in the trigeminal system. Zolmitriptan is a selective 5-hydroxytryptamine 1B/1D receptor agonist with a weak affinity for the 5-HT 1A receptor subtypes. This activity describes the indications, action, and contraindications for zolmitriptan as a valuable agent in the treatment of acute migraines. In addition, this activity will highlight the mechanism of action, adverse event profile, toxicity, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the healthcare team in the treatment of patients with migraine and related conditions.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the mechanism of action of zolmitriptan.
  • Describe the contraindications of zolmitriptan.
  • Review the common adverse effects of zolmitriptan.
  • Outline some interprofessional team strategies for improving care coordination and communication to advance zolmitriptan and improve outcomes.


StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Anesthesiology
  • Pain Medicine
American Board of Internal Medicine
  • Internal Medicine

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


    Alana H. on 8/26/2021

    Harry A. on 10/17/2021

    Sarah A. on 11/16/2021

    1. Text states: "Zolmitriptan is the generic formulation of two branded products." How about naming those products? 2. Text stats: "The maximum recommended daily dose is 10mg for adults and pediatric patients ages 12 to 17." This sentence does not flow well.

    john e. on 2/14/2022

    Janice on 3/15/2022

    Dr Haresh D. on 3/28/2022

    cyvada s. on 5/4/2022

    Christine D. on 5/13/2022

    Paul H. on 5/14/2022

    Shelia C. on 5/15/2022

    Megan G. on 5/19/2022

    Alexandra G. on 6/13/2022

    Rohit A. on 7/6/2022

    Brittany T. on 8/1/2022

    Victoria S. on 8/23/2022

    Alex N. on 8/30/2022

    Emily A. on 9/19/2022

    Mark O. on 10/24/2022

    Kecia T. on 12/26/2022

    long h. on 12/27/2022

    Laurie C. on 12/28/2022

    Natalie p. on 1/3/2023

    Connie D. on 1/3/2023

    Lisa B. on 1/29/2023

    Nancy H. on 1/30/2023

    Dr Jagveer S. on 3/26/2023

    Unlimited Physician CME

    Stay up to date on the latest medical knowledge with 6674 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7931 hours of CME.

    Learn About Lifetime CME

    Single Activity

    Take this single activity

    $39 1 activity

    6 Month Unlimited Physician CME

    Access to all the Unlimited Physician CME activities in all specialties.

    $289 per half year per user

    1 Year Unlimited Physician CME

    Access to all the Unlimited Physician CME activities in all specialties.

    $399 per 1 year per user