Bone Marrow Transplantation in Sickle Cell Disease

Overview

4.2 out of 5 (8 Reviews)

Credits

1.00

Post Assessment Questions

5

Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

60 Minutes

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Activity Description

Since the Sickle Cell Anemia Act, there has been progress in the screening and treatment of sickle cell disease. For instance, in most parts of the United States, sickle cell screening is done before babies are discharged from the hospital. As a result, parents know the status of their baby, leading to early medical intervention at a young age and reducing morbidity and mortality. Treatment of sickle cell disease has also improved, including the use of penicillin prophylaxis for patients less than 5 years old, the use of hydroxyurea for increasing the number of fetal hemoglobin, blood transfusions, and pain medications, including opioids. Most of these treatments are palliative, and unfortunately, patients still have a poor quality of life because of extreme pain episodes, end-organ damage, and also a reduced life expectancy. In September 2018, the National Heart, Lung, and Blood Institute (NHLBI) launched the Cure Sickle Cell Initiative. Advancement in new gene therapy has shown a promising result in both preclinical and clinical trials. This new technology will entail removing the patient’s stem cells from the bone marrow and then adding a therapeutic gene to those cells, which will then lead to the production of anti-sickling cells. This activity reviews the role of bone marrow transplant (BMT) in sickle cell disease and highlights the role of the interprofessional team in the management of these patients.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Outline the indications for bone marrow transplant in sickle cell disease.
  • Describe the complications of bone marrow transplant in sickle cell disease.
  • Summarize the technique of bone marrow transplant in sickle cell disease.
  • Summarize the importance of care coordination among interprofessional team members to improve outcomes for patients with sickle cell undergoing bone marrow transplants.

Disclosures

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COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Internal Medicine
  • Adolescent Medicine
  • Internal Medicine
  • Hematology
  • Rheumatology
American Board of Pathology
  • Clinical Pathology
  • Hematology (Blood, BM)
  • Molecular Genetic Pathology
American Board of Pediatrics
  • Adolescent Medicine
  • General Pediatrics
  • Pediatric Rheumatology
American Board of Surgery
  • Surgical Critical Care

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  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

Disclaimer

Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 

 

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The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.

    Reviews

    MOSFER A. on 9/4/2022

    Micah L. on 12/28/2021

    Jennifer K. on 3/2/2022

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    Samantha h. on 8/28/2022

    Rita B. on 9/11/2022

    Khelsea C. on 12/16/2022

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