Acanthosis Nigricans


4.7 out of 5 (97 Reviews)



Post Assessment Questions


Expiration Date

28 Feb 2026

Last Reviewed

1 Mar 2023

Estimated Time To Finish

90 Minutes

Need Help?  If you have a system or content concerns, please contact

Activity Description

Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives. This activity reviews the workup and treatment of acanthosis nigricans and highlights the role of the interprofessional team in evaluating and treating patients with acanthosis nigricans.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify some of the more common and some of the less common etiologies of acanthosis nigricans.
  • Describe the management of acanthosis nigricans, and list any further evaluation that should be considered.
  • Explain the pathophysiologic basis for acanthosis nigricans.
  • Articulate the role of interprofessional team members in evaluating and treating patients with acanthosis nigricans.


StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Internal Medicine
  • Adolescent Medicine
  • Endocrinology, Diabetes, and Metabolism
  • Internal Medicine
American Board of Pathology
  • Dermatopathology
  • Molecular Genetic Pathology
American Board of Pediatrics
  • Adolescent Medicine
  • General Pediatrics
  • Pediatric Endocrinology

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on the applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Quillen College of Medicine, East Tennessee State University reserve the right to cancel any course due to unforeseen circumstances. StatPearls andQuillen College of Medicine, East Tennessee State University will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls andQuillen College of Medicine, East Tennessee State University are Equal Opportunity/Affirmative Action/Equal Access Institutions. 


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.

  • Name: 'Acanthosis-nigricans.jpg' Attribution: Contributed by Scott Dulebohn, MD
  • Name: 'acanthosis nigricans.jpg' Attribution: Contributed by DermNetNZ
  • Name: 'Skin Tag Removal.png' Attribution: Contributed by Dr. Amarendra Pandey
  • Name: 'Acanthosis nigricans SV1.JPG' Attribution: Contributed by Dr. Shyam Verma, MBBS, DVD, FRCP, FAAD, Vadodara, India
  • Name: 'Acanthosis nigricans SV2.JPG' Attribution: Contributed by Dr. Shyam Verma, MBBS, DVD, FRCP, FAAD, Vadodara, India


Deborah Z. on 1/10/2021


Resham V. on 2/3/2021

Bridget R. on 2/24/2021

Neeraj H. on 5/21/2021

Michelle W. on 8/19/2021

JANE P. on 8/23/2021

Helena a. on 9/2/2021

Casey B. on 9/17/2021

Harry A. on 9/26/2021

Mary K. on 10/18/2021

Diane P. on 10/25/2021

Sara C. on 11/2/2021

Carly S. on 11/11/2021

very educational

shelley h. on 11/15/2021

Eddie S. on 11/28/2021

COURTNEY M. on 1/2/2022

Carrie G. on 12/16/2021

SANDRA R. on 12/27/2021

SREEDEVI Y. on 1/1/2022

shelley h. on 12/11/2022

jennifer s. on 1/5/2022

sanaz l. on 1/15/2022

Emily E. on 2/25/2022

devin n. on 2/26/2022

Sherrika W. on 3/10/2022

This activity will help me better care for my patients.

BURTON L. on 3/14/2022

Angela G. on 6/16/2022

Jacinta U. on 5/9/2022

lesha s. on 5/13/2022

Christian M. on 5/13/2022

Shelia C. on 5/15/2022

erika w. on 5/17/2022

Lacey S. on 5/20/2022

Ejaz J. on 5/22/2022

Amy R. on 5/26/2022

Jacqueline S. on 5/31/2022

Stephanie C. on 6/5/2022

I should not be forced to complete a survey for a paid service

Gerald O. on 6/22/2022

Alexandra G. on 6/24/2022

Shannon j. on 6/27/2022

Nassifatou B. on 6/29/2022

Julie l. on 7/16/2022

Alyssa B. on 7/19/2022

Tracy L. on 7/21/2022

Kaitlin C. on 8/12/2022

MANJARI G. on 8/19/2022

Victoria S. on 8/25/2022

Michael A. on 8/29/2022

Alex N. on 8/30/2022

Muammar A. on 9/3/2022

Maura F. on 9/30/2022

Laura A. on 10/1/2022

Simranjit K. on 10/11/2022

Sheena A. on 10/11/2022

Savannah R. on 10/12/2022

Good review.

John B. on 10/23/2022

Joseph S. on 10/25/2022

Michele H. on 11/2/2022

Stephanie T. on 11/10/2022

Charles W. on 11/12/2022

April K. on 11/13/2022

Li Mei L. on 11/20/2022

Amr K. on 11/23/2022

richard k. on 12/6/2022

SOLOMON O. on 12/3/2022

Connie D. on 12/5/2022

Jaspreet K. on 12/15/2022

NISHA N. on 12/15/2022

Southern A. on 12/14/2022

Larry M. on 12/17/2022

Kecia T. on 12/19/2022

Laurel S. on 12/21/2022

Kelli M. on 12/22/2022

Karl S. on 12/23/2022

Ingerlisa M. on 12/23/2022

Sean S. on 12/27/2022

Donald S. on 1/1/2023

Natalie p. on 1/2/2023

Brenna B. on 1/4/2023

Monika S. on 1/5/2023

Li Mei L. on 1/7/2023

syble c. on 1/11/2023

Nancy H. on 1/15/2023

Patricia F. on 1/15/2023


Sarah V. on 1/20/2023

Li s. on 1/24/2023

Lisa B. on 1/25/2023

Arthur L. on 2/2/2023

Katherine L. on 2/7/2023

Candice H. on 2/7/2023

Amy S. on 2/16/2023

Kurni R. on 2/21/2023

Nicole W. on 2/21/2023

Julie E. on 2/23/2023

Bashiru B. on 2/28/2023

Grace N. on 3/7/2023

Karl S. on 3/18/2023

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6674 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7931 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$39 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$289 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$399 per 1 year per user