Lipoprotein X-Induced Hyperlipidemia

Overview

3 out of 5 (1 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Jan 2021

Last Review Date

8 Jan 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Lipoprotein X (Lp-X)-induced hyperlipidemia is a rare condition primarily seen in liver dysfunction, notably in cholestasis-related conditions. This abnormal lipoprotein, Lp-X, lacks apolipoprotein B100 and contributes to severe elevations in cholesterol levels. While atherosclerosis is uncommon, Lp-X accumulation leads to skin xanthomas, thrombotic events, and hyperviscosity syndrome, potentially fatal complications. Diagnosis involves challenging laboratory interpretations due to interference with LDL calculations and apolipoprotein analyses. Management revolves around addressing the underlying liver dysfunction, considering therapies like ursodeoxycholic acid, obeticholic acid (for primary biliary cholangitis), and fibrate therapy in select cases. Plasmapheresis might be used for severe complications, but liver transplantation remains the definitive treatment for primary liver disease.

This activity discusses the intricacies of hyperlipidemia associated with Lp-X accumulation, offering a comprehensive exploration of its unique etiology, clinical presentation, and management. While hyperlipidemia is a well-established risk factor for cardiovascular disease, LpX-induced hyperlipidemia presents a distinct clinical picture with no associated increase in cardiovascular risk. Instead, it is closely linked to cholestatic liver disorders, making its prognosis and management markedly different from conventional hyperlipidemia. Through course participation, participants will be equipped with the specialized knowledge needed to navigate the complexities of LpX-induced hyperlipidemia confidently. An interprofessional team approach ensures a holistic and well-informed approach to managing LpX-induced hyperlipidemia This collaborative effort not only enhances the competence of each team member but also optimizes patient care, leading to improved clinical outcomes.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the common causes of lipoprotein X-induced hyperlipidemia.

  • Assess the clinical features and distinctive lipid profile patterns associated with Lipoprotein X-induced hyperlipidemia to facilitate accurate and early diagnosis.

  • Implement the typical management and treatment considerations for patients with lipoprotein X-induced hyperlipidemia.

  • Explain the role of an interprofessional team in managing patients with lipoprotein X-induced hyperlipidemia to help improve clinical outcomes for these patients.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

christopher k. on 8/17/2022

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