Tricyclic Antidepressant Toxicity

Overview

4.6 out of 5 (7 Reviews)

Credits

1.25

Post Assessment Questions

12

Expiration Date

31 Dec 2023

Last Reviewed

1 Jan 2021

Estimated Time To Finish

75 Minutes

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Activity Description

Tricyclic antidepressants (TCAs) were introduced in the late 1950s for the treatment of depression. With the advent of selective serotonin reuptake inhibitors (SSRIs) and other new antidepressants, the use of TCAs has decreased, although they are still used to treat depression that has not responded to treatment with less toxic agents. In adults, TCAs are also used for migraine headache prophylaxis, treatment of neuralgic pain, including the pain associated with Ciguatera poisoning, and obsessive-compulsive disorder. In children, TCAs have been used to treat nocturnal enuresis. Despite the current limited use of TCAs, TCA-overdose-associated hospitalizations and fatalities are on the rise. This activity reviews the evaluation and management of tricyclic antidepressant toxicity and highlights the role of interprofessional team members in collaborating to provide well-coordinated care and enhance outcomes for affected patients.

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Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the pathophysiology of tricyclic antidepressant toxicity.
  • Review the history and physical exam of a patient with tricyclic antidepressant toxicity.
  • Summarize the treatment options for tricyclic antidepressant toxicity.
  • Explain the importance of improving care coordination among interprofessional team members to improve outcomes for patients affected by tricyclic antidepressant toxicity.

Author(s) / Contributors Disclosure of Conflicts of Interest

Each author, editor, faculty and planning committee member have completed a disclosure form indicating that neither they nor their spouse/partner has a financial interest/arrangement or affiliation that could be perceived as a real or apparent conflict of interest related to the content of this activity.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.25 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Internal Medicine
  • Internal Medicine
American Board of Pathology
  • Chemical Pathology
  • Forensic Pathology
American Board of Pediatrics
  • General Pediatrics
  • Medical Toxicology

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  • StatPearls and ETSU reserve the right to cancel any course due to unforeseen circumstances. StatPearls and ETSU will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and ETSU are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

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Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives, and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation survey. 
  7. Obtain a certificate.

StatPearls and ETSU adhere to ACCME Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and ETSU that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

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    Reviews

    Thomas P. on 3/14/2021

    brandi m. on 3/30/2021

    Caleb P. on 7/28/2021

    Jessica S. on 11/14/2021

    MIA G. on 2/3/2022

    Jacklyn V. on 5/26/2022

    Finally some relatively straightforward questions that were pertinent.

    Brian G. on 5/28/2022

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