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Expiration Date

31 Dec 2023

Last Reviewed

1 Jan 2021

Estimated Time To Finish

75 Minutes

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Activity Description

Amitriptyline is FDA approved medication to treat depression in adults. The Non-FDA approved indications are anxiety, post-traumatic stress disorder, insomnia, chronic pain (diabetic neuropathy, fibromyalgia), irritable bowel syndrome, interstitial cystitis (bladder pain syndrome), migraine prophylaxis, postherpetic neuralgia, and sialorrhea. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of amitryptiline in the clinical setting related to the essential points needed by members of an interprofessional team managing the care of patients that can benefit from amitriptyline therapy.

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Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the mechanism of action of amitriptyline.
  • Describe FDA-approved and off-label indications of amitriptyline.
  • Review the appropriate adverse drug reactions of amitriptyline.
  • Outline interprofessional team strategies for improving patient outcomes.

Author(s) / Contributors Disclosure of Conflicts of Interest

Each author, editor, faculty and planning committee member have completed a disclosure form indicating that neither they nor their spouse/partner has a financial interest/arrangement or affiliation that could be perceived as a real or apparent conflict of interest related to the content of this activity.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.25 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Anesthesiology
  • Ambulatory/Outpatient
  • General Operative Anesthesia
  • Sleep Medicine
American Board of Internal Medicine
  • Cardiovascular Disease
  • Endocrinology, Diabetes, and Metabolism
  • Internal Medicine
  • Gastroenterology
American Board of Otolaryngology
  • Sleep Medicine
American Board of Pathology
  • Cardiovascular
  • Endocrine
  • GI (incl. Liver, Pancreas, Bilary)
  • Hematology (Blood, BM)
  • Male Genital
  • Neuropathology (incl. Neuromuscular)
  • Urinary Tract
American Board of Pediatrics
  • Pediatric Cardiology
  • Pediatric Endocrinology
  • Pediatric Nephrology
  • Pediatric Neurology
  • Pediatric Pulmonology
  • Sleep Medicine

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearls and ETSU reserve the right to cancel any course due to unforeseen circumstances. StatPearls and ETSU will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and ETSU are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives, and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation survey. 
  7. Obtain a certificate.

StatPearls and ETSU adhere to ACCME Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and ETSU that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

  • If you need help with the system or have a question about content, please contact, or call 727-289-9796.
  • If you have a question about the ETSU CME providership, please contact


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


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    Thank you

    Douglas T. on 12/5/2021


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    Samantha B. on 5/6/2022

    There is a vast difference in the questions presented.Some of them give a clear and concise presentation. Meds and conditions are listed and we can make a sound decision. Other questions yield very little information and require us to do a lot of assuming when there in fact, could be multiple different causes for a patient's presentation.

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    Appreciate the education!

    Eddie T. on 7/2/2022

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