Overview

4.7 out of 5 (15 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Jan 2021

Last Review Date

14 Feb 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Doxepin belongs to the class of tricyclic antidepressant medications approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder, anxiety, and insomnia, as well as for managing skin pruritus. Doxepin functions by increasing the concentration of the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) and norepinephrine (NE) in the brain. This mechanism extends the availability of the neurotransmitters (5-HT and NE) within the synaptic cleft and enhances their neurotransmission by preventing their reuptake into the presynaptic terminal.

Doxepin also displays antagonistic effects in the central nervous system by blocking receptors such as histamine (H1), α1 adrenergic, and muscarinic. Furthermore, doxepin inhibits sodium and potassium channels in cardiomyocytes, thereby broadening the drug's indications profile. This activity provides an overview of doxepin's indications, administration, mechanism of action, adverse effects, contraindications, and toxicity to improve the competence of the interprofessional healthcare team in administering the drug safely and effectively. This activity highlights the importance of utilizing a team-based approach to treat patients with major depressive disorder. Collaborative care involving primary care, psychiatry, and other related disciplines would optimize patient outcomes.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the appropriate indications for prescribing doxepin, including its approved uses in the treatment of major depressive disorder, anxiety disorders, and insomnia.

  • Implement appropriate dosing strategies for initiating doxepin therapy, considering the recommended titration schedule and the need for dosage adjustments based on individual patient response and tolerability.

  • Select the most appropriate formulation, dose, and dosing schedule of doxepin based on individual patient factors, preferences, and treatment goals.

  • Collaborate with interdisciplinary healthcare team members to provide comprehensive care for patients receiving doxepin therapy, addressing both psychiatric and psychosocial needs.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

ROY A. on 10/19/2021

Christopher N. on 6/1/2022

David G. on 8/1/2022

Marlen L. on 10/18/2022

Alyssa C. on 1/22/2023

Latoya R. on 1/29/2023

Shirley A. on 4/13/2023

Susan M. on 4/21/2023

Lily L. on 4/26/2023

Michael P. on 6/5/2023

Kathleen P. on 6/21/2023

Christa R. on 9/6/2023

Margaret D. on 1/2/2024

Jibril Y. on 2/20/2024

Margaret M. on 3/28/2024

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