Liddle Syndrome (Pseudohyperaldosteronism)

Overview

4.7 out of 5 (7 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Jan 2021

Last Review Date

1 Mar 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Liddle syndrome, also known as pseudohyperaldosteronism, is one of the rare causes of resistant hypertension that presents in early childhood. The syndrome is a rare cause of secondary hypertension due to a genetic mutation affecting the function of the collecting tubule sodium channel. This hereditary condition follows a dominant pattern of inheritance; typical symptoms include hypertension, hypokalemia, and metabolic alkalosis. Pathophysiologically, the levels of the hormones aldosterone and renin are low. Managing clinicians may see features overlapping with renal and related endocrinological diseases, such as renal tubular acidosis, diabetes mellitus, and Cushing syndrome.

Furthermore, the course addresses the challenges clinicians may encounter due to overlapping features with other renal and endocrinological conditions, such as renal tubular acidosis, diabetes mellitus, and Cushing syndrome. This activity reviews this syndrome's causes, symptoms, evaluation, and treatment and discusses the interprofessional team's role in diagnosing and managing the condition.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Select appropriate pharmacological agents, including epithelial sodium channel blockers, as first-line therapy for managing hypertension and electrolyte abnormalities in patients with Liddle syndrome, considering individual patient characteristics and comorbidities.

  • Determine the workup to establish Liddle syndrome, including potential differential diagnoses.

  • Assess the effectiveness of treatment interventions and monitor for potential complications associated with Liddle syndrome, such as electrolyte imbalances and cardiovascular sequelae, through regular clinical evaluations and laboratory monitoring.

  • Collaborate with interprofessional healthcare teams, including primary care physicians, endocrinologists, nephrologists, and genetic counselors, to facilitate comprehensive evaluation, diagnosis, and management of Liddle syndrome.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Anna I. on 8/1/2021

Christine U. on 2/26/2022

Karl S. on 2/12/2023

Valentine C. on 5/26/2023

Shirley A. on 9/16/2023

Kathleen on 10/16/2023

Fatima H. on 12/18/2023

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