Organophosphate Toxicity

Overview

4.3 out of 5 (3 Reviews)

Credits

1.50

Post Assessment Questions

6

Start Date

1 Jan 2021

Last Review Date

12 Nov 2023

Expiration Date

31 Dec 2023

Estimated Time To Finish

90 Minutes


 
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Activity Description

Organophosphates encompass a diverse group of chemical compounds with common applications in pesticides and herbicides, as well as nerve agents in chemical warfare. When introduced into the body, organophosphates inhibit the enzyme acetylcholinesterase, resulting in an overabundance of the neurotransmitter acetylcholine. This surplus of acetylcholine in the body manifests with cholinergic toxidrome, which includes effects on nicotinic and muscarinic receptors, as well as the central nervous system. Respiratory failure resulting from bronchorrhea and bronchospasm is the leading cause of death in cases of organophosphate toxicity. Chronic toxicity and neurological complications, such as the intermediate syndrome, are also well documented. Although developed nations have experienced a decline in poisoning cases due to stricter regulations on the use of these chemicals, developing countries still face a clinical concern, especially when these chemicals are used for self-harm purposes. Antidotal therapy and comprehensive supportive care from healthcare professionals are necessary for the effective treatment of organophosphate toxicity to prevent morbidity and mortality. This activity reviews the assessment and treatment of organophosphate toxicity while highlighting the role of the interprofessional healthcare team in recognizing organophosphate toxicity and treating patients with this condition.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the clinical signs and symptoms indicative of organophosphate toxicity, including manifestations of cholinergic toxidromes, such as miosis, diaphoresis, and bronchorrhea.

  • Assess the severity of organophosphate toxicity using clinical scoring systems, such as the Peradeniya Organophosphorus Poisoning (POP) scale, to guide treatment decisions and predict prognosis.

  • Select the appropriate dosage and administration route for atropine and pralidoxime based on the patient's age, weight, and clinical presentation.

  • Collaborate with an interdisciplinary healthcare team, including emergency medicine physicians, intensivists, and toxicologists, for cases of severe organophosphate toxicity to ensure that patients receive timely and appropriate care in an intensive care setting.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.50 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Bhupendra G. on 3/18/2022

Ehsan Q. on 5/28/2023

Eric F. on 2/28/2024

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