Delayed Hypersensitivity Reactions

Delayed Hypersensitivity Reactions

Credits: 1.00   Post-Assessment Questions:  6

Release Date: 5 Oct 2020
Expiration Date: 30 Dec 2021
Last Reviewed: 30 Dec 2020
Estimated Time To Finish: 60 Minutes

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Activity Description

Coombs and Gel classified type IV hypersensitivity reaction (HR) as a delayed hypersensitivity reaction (DHR), which takes more than 12 hours to develop. Typically the maximal reaction time occurs between 48 to 72 hours. Antibodies do not mediate DHR; it is mediated by T cells that cause an inflammatory reaction to either exogenous or autoantigens. This HR to exogenous antigens involves T cells and also antigen-presenting cells (APC) such as macrophages and dendritic cells, all produce cytokines that stimulate a local inflammatory response in a sensitized individual. The DHR to autoantigens can be seen in type 1 diabetes mellitus, which is an autoimmune disease that results from autoimmune cell-mediated destruction of insulin-secreting pancreatic beta cells. DHR cannot be transferred from an animal to another by means of antibodies or serum. However, it can be transferred by T cells, particularly CD4 Th1 cells, but it is progressively lost in individuals with HIV/AIDS. Antigen-presenting cells (APC) such as Langerhans cells engulf process and present antigens to antigen-specific T cells that become sensitized. Cytokines produced by keratinocytes, APC, and T cells recruit antigen-nonspecific T cells and macrophages to participate in a local inflammatory reaction. The activity describes the interprofessional evaluation and management of patients with delayed hypersensitivity reactions.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

• Describe the signs and symptoms of delayed hypersensitivity reactions.
• Identify how the diagnosis of delayed hypersensitivity reaction is confirmed.
• Explain treatment considerations for patients with a delayed hypersensitivity reaction.

Author(s) / Contributors Disclosure of Conflicts of Interest

Each author, editor, faculty and planning committee member have completed a disclosure form indicating that neither they nor their spouse/partner has a financial interest/arrangement or affiliation that could be perceived as a real or apparent conflict of interest related to the content of this activity.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Contributors

Hover over the contributor names to see details and disclosures of any financial relationships or relationships they or their spouse/life partner have with commercial interests related to the content of this continuing education activity.

Authors: Angel Justiz Vaillant, Hassam Zulfiqar
Editors: Kamleshun Ramphul
Editors-In-Chief: Joshua TuckPrashanth AnandMatthew Varacallo
Chief Medical Reviewer: Matthew Varacallo
Nurse Planner/Reviewer/Editor: Lisa Haddad
Nurse Planner/Reviewer/Editor: Bernadette Makar
Nurse Planner/Reviewer/Editor: Dorothy Caputo
Pharmacy Planner/Reviewer/Editor: Mark Pellegrini
Physician Planner/Reviewer/Editor: Scott Dulebohn

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

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Equal Opportunity

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Instructions for Credit

1. Register for the activity and create a StatPearls login.     
2. Review the required accreditation information:  Target audience, learning objectives, and disclosure information.
3. Complete the entire self-study activity.
4. Complete the post-test assessments.
5. Successfully pass the post-test with a minimum score of 100%.
6. Complete the evaluation form.
7. Obtain a certificate.

StatPearls and ETSU adhere to ACCME Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and ETSU that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

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