Isoniazid Toxicity

Overview

4.2 out of 5 (6 Reviews)

Credits

1.50

Post Assessment Questions

9

Start Date

1 Jan 2021

Last Review Date

28 Feb 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

90 Minutes


 
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Activity Description

Isoniazid (INH) is a potent bactericidal antibiotic prescribed for tuberculosis (TB). Treatment with INH therapy has a risk of toxicity, which is acute or chronic, leading to long-term liver damage if not appropriately treated. Acute toxicity manifests as neurological symptoms, often in the form of seizures refractory to benzodiazepines. Chronic toxicity usually presents as hepatotoxicity and peripheral neuropathy. The toxicity may easily present in the full spectrum of medical settings, though less likely in emergency departments, if pyridoxine is prescribed with INH from therapy initiation. With increasing INH prescriptions for TB, cases of INH toxicity may rise due to dosage errors. Management includes discontinuing INH, administering pyridoxine for acute toxicity, considering liver support therapies if hepatic damage occurs, and occasionally resorting to liver transplants.

Throughout this activity, participants explore the spectrum of INH toxicity presentations, learning to recognize key features and differentiate them from other drug toxicities. Emphasis is placed on early intervention strategies, including administering pyridoxine for acute toxicity and appropriate management of chronic hepatotoxicity. Moreover, this course underscores the importance of an interprofessional approach in managing INH toxicity, highlighting the collaborative efforts of clinicians across specialties. By participating in this course, clinicians enhance their competence in recognizing, diagnosing, and managing INH toxicity, ultimately improving patient outcomes and ensuring safe prescribing practices in TB treatment.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Determine the pathophysiology of isoniazid (INH) toxicity, including both acute and chronic presentations.

  • Interpret the presentation of isonizaid toxicity to determine the next best steps appropriately.

  • Implement the treatment options for isoniazid toxicity, considering medication interactions and exposure duration.

  • Coordinate strategies among interprofessional team members to identify patients affected by isoniazid toxicity and treat the condition rapidly.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.50 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Dr.NIRMALA M. on 11/15/2022

Christine G. on 11/15/2022

Christine G. on 1/2/2023

Adithya nikhileshwar B. on 9/5/2023

Akshaya K. on 11/11/2023

Nivetha V. on 1/9/2024

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