Donepezil

Overview

4.7 out of 5 (40 Reviews)

Credits

1.50

Post Assessment Questions

10

Start Date

1 Jan 2021

Last Review Date

17 Aug 2023

Expiration Date

31 Dec 2023

Estimated Time To Finish

90 Minutes


 
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Activity Description

Donepezil hydrochloride, a piperidine derivative, is a centrally acting, rapid, and reversible acetylcholinesterase inhibitor primarily utilized for treating Alzheimer disease. Acetylcholinesterase is an enzyme that breaks down acetylcholine after its release from the presynapse. By binding reversibly to acetylcholinesterase, donepezil inhibits acetylcholine hydrolysis, thereby increasing acetylcholine availability at the synapses and enhancing cholinergic transmission. The U.S. Food and Drug Administration (FDA) approved the drug for the treatment of dementia in mild, moderate, and severe Alzheimer disease. Although there is currently no evidence to suggest that donepezil can alter the progression of the disease, it has shown efficacy in alleviating specific symptoms by improving cognition and/or behavior in affected individuals. In addition to its FDA-approved use in Alzheimer disease, donepezil has various off-label indications. This activity emphasizes the mechanism of action, adverse event profile, pharmacokinetics, monitoring requirements, and relevant drug interactions of donepezil. This information is crucial for interprofessional team members involved in treating patients with dementia associated with Alzheimer disease.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify appropriate candidates for donepezil therapy based on clinical criteria and diagnostic guidelines for Alzheimer disease.
  • Screen patients for potential contraindications, comorbidities, or risk factors associated with donepezil, which may influence the use of the drug in Alzheimer treatment.
  • Assess the treatment efficacy and tolerability of donepezil in patients with Alzheimer disease through regular cognitive and behavioral evaluations.
  • Coordinate ongoing monitoring and follow-up care among healthcare professionals, caregivers, and support systems to address the potential issues and complex needs of patients receiving donepezil for Alzheimer disease management.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.50 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Thomas P. on 3/20/2021

devin n. on 2/26/2022

Janet M. on 5/3/2022

Angjelin S. on 5/3/2022

Carolyn G. on 5/22/2022

Kimberly G. on 6/21/2022

Soheyla M. on 7/8/2022

Natalia M. on 8/21/2022

victoria s. on 8/23/2022

Nicole F. on 8/29/2022

Nicole G. on 9/6/2022

IRIS O. on 9/25/2022

Darra H. on 1/6/2023

Abrah N. on 1/13/2023

MARGARONE M. on 1/25/2023

jubril o. on 1/24/2023

Wayne S. on 1/29/2023

JOSE P. on 2/7/2023

Dominika S. on 2/8/2023

amy s. on 2/16/2023

Tammy S. on 3/28/2023

Jennifer P. on 4/15/2023

Arash S. on 4/22/2023

Lily L. on 4/26/2023

James N. on 5/31/2023

Kimberley R. on 6/5/2023

Hiroko P. on 6/7/2023

Peter M. on 6/13/2023

Amy G. on 8/1/2023

Yan L. on 9/28/2023

Theresa M. on 10/5/2023

Daniel S. on 10/6/2023

Sarah B. on 10/30/2023

Nanette M. on 12/3/2023

Lisa S. on 12/7/2023

alex b. on 1/21/2024

Joseph S. on 2/11/2024

Jibril Y. on 2/19/2024

Vincent B. on 3/18/2024

It would be helpful if this activity also included the co-treatment options with other medications for dementia to present a more well-rounded picture of treatment and titration options.

Nellyda A. on 4/8/2024

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