Leukocytosis

Overview

4.5 out of 5 (11 Reviews)

Credits

1.50

Post Assessment Questions

9

Start Date

1 Sep 2023

Last Review Date

21 Apr 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


 
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Activity Description

Leukocytosis, characterized by an elevation in the white blood cell count, is a common clinical finding with various potential causes, encompassing infections, inflammation, malignancies, and hereditary disorders. The threshold for leukocytosis varies with age and pregnancy status, with significant deviations from typical values prompting further evaluation. Identifying changes in the distribution of white blood cells aids in pinpointing the underlying cause, such as eosinophilia indicating allergic reactions or parasitic infections and lymphocytosis suggestive of viral syndromes or autoimmune diseases. While many cases of leukocytosis resolve without intervention, some may necessitate urgent evaluation for leukemia or myeloproliferative disorders.

Evaluating leukocytosis involves assessing clinical features, duration of results, the differential, and remaining complete blood count parameters. In cases of persistent leukocytosis, bone marrow aspiration and biopsy may be necessary to differentiate leukemia from benign conditions. Treatment of leukocytosis is often not required. Cases of leukemia, lymphoma, or hyperleukocytosis syndrome, where interventions like leukapheresis and chemotherapy may be necessary, are exceptions. Management strategies address the underlying etiology, emphasizing a comprehensive approach to patient care guided by diagnostic findings and clinical expertise. 

This activity discusses the etiology and pathophysiology of leukocytosis, offering nuanced perspectives on its assessment. Healthcare professionals will gain invaluable insights into accurately evaluating leukocytosis and employing evidence-based treatment strategies, emphasizing the importance of tailored management plans directed at the underlying cause. This comprehensive course empowers clinicians with essential knowledge and resources to optimize care for patients with this prevalent condition.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Differentiate between benign leukocytosis and conditions warranting urgent evaluation, such as hyperleukocytosis syndrome or leukemia.

  • Assess the need for further investigations, such as bone marrow biopsy, in cases of persistent leukocytosis to evaluate for malignancies.

  • Implement evidence-based treatment strategies for leukocytosis.

  • Collaborate with an interprofessional healthcare team to optimize patient care and coordinate transitions between care settings.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Otolaryngology–Head and Neck Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn their required annual part II self-assessment credit in the American Board of Otolaryngology–Head and Neck Surgery’s Continuing Certification program (formerly known as MOC). It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of recognizing participation.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Trista P. on 8/15/2021

Diane P. on 11/14/2021

Ronita B. on 7/2/2022

Harriette S. on 8/1/2022

Katrina T. on 8/18/2022

Richard H. on 12/25/2022

Swaminathan I. on 8/25/2023

Richard S. on 12/21/2023

Jeffrey W. on 1/15/2024

Dr Sruthi G. on 2/13/2024

Kelli M. on 4/11/2024

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