Cephalosporins

Overview

4.6 out of 5 (50 Reviews)

Credits

1.50

Post Assessment Questions

7

Start Date

1 Jan 2021

Last Review Date

17 Feb 2024

Expiration Date

31 Dec 2023

Estimated Time To Finish

90 Minutes


 
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Activity Description

Cephalosporins are β-lactam antimicrobials used to manage various infections caused by both gram-positive and gram-negative bacteria. The 5 generations of cephalosporins demonstrate efficacy in treating skin and soft tissue infections, pneumonia, meningitis, and other infections. Cefiderocol is a novel siderophore cephalosporin that exhibits remarkable antibacterial activity. This drug has been approved by the US Food and Drug Administration (FDA) to treat complicated urinary tract infections and ventilator-associated pneumonia caused by highly resistant gram-negative bacteria, including Klebsiella pneumoniaProteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii.

Cefiderocol emerges as a promising therapeutic option for challenging infections, with literature reviews suggesting its potential in combating strains resistant to carbapenems. Importantly, cefiderocol is the only recently approved β-lactam agent exhibiting in vitro activity against carbapenem-resistant A baumannii (CRAB) isolates. According to the Infectious Diseases Society of America guidelines, cefiderocol should be reserved for cases of CRAB infections that remain unresponsive to other antibiotics or when intolerance to alternative agents prohibits their use. This activity provides clinicians with comprehensive insights into indications, mechanisms of action, contraindications, monitoring protocols, potential adverse drug reactions, and clinical toxicology associated with cephalosporins. This activity also provides healthcare professionals with essential knowledge and necessary tools to make informed decisions, promptly identify adverse effects, and optimize patient outcomes through vigilant monitoring and effective cephalosporin utilization, thereby ensuring proficiency in antibiotic therapy.


Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the spectrum of activity of cephalosporins against both gram-positive and gram-negative bacteria.

  • Screen patients for potential contraindications and drug interactions before initiating cephalosporin therapy.

  • Implement appropriate dosing regimens and administration routes for cephalosporins based on the type and severity of infection.

  • Coordinate with other healthcare team members to ensure timely and appropriate use of cephalosporins in multidisciplinary patient care plans.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.50 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Mary S. on 7/27/2021

DIMITRIOS T. on 9/10/2021

Mirta A. on 10/19/2021

Laura B. on 12/28/2021

Brandy M. on 5/16/2022

Robin A. on 5/20/2022

Mica C. on 5/25/2022

Cara P. on 5/30/2022

Mark W. on 6/16/2022

Jennifer L. on 7/4/2022

Very educational.

Kelly A. on 8/24/2022

Christine G. on 10/28/2022

Dr.NIRMALA M. on 11/28/2022

Florence Y. on 1/14/2023

kevin n. on 1/20/2023

Austin S. on 1/20/2023

Skyler S. on 1/26/2023

Abbie J. on 2/25/2023

Raven H. on 3/17/2023

Haley K. on 3/31/2023

I wish there were tables to help me mentally stratify the cephalosporins.

john e. on 4/2/2023

Aaron M. on 4/18/2023

Rachel E. on 4/21/2023

Brianna B. on 4/24/2023

MELISSA B. on 5/10/2023

Cheyenne T. on 5/13/2023

Heather D. on 5/24/2023

Sheila C. on 6/17/2023

Matthew P. on 7/21/2023

Kara W. on 8/16/2023

Kathern R. on 9/21/2023

roxanna g. on 10/4/2023

Shelli H. on 10/21/2023

channa p. on 10/24/2023

Christine G. on 10/26/2023

Jack I. on 11/2/2023

Keaton A. on 11/14/2023

Matthew S. on 11/28/2023

John S. on 12/18/2023

makondo s. on 12/11/2023

Laura G. on 12/12/2023

Hawabu S. on 12/21/2023

Benjamin W. on 12/26/2023

Mandy H. on 12/27/2023

Stephen B. on 1/1/2024

Leila Z. on 2/25/2024

Kelly T. on 2/21/2024

John H. on 3/18/2024

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Gary A. on 4/4/2024

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