BRCA1 and BRCA2 Mutations

Overview

4.7 out of 5 (55 Reviews)

Credits

1.00

Post Assessment Questions

8

Start Date

19 Jul 2022

Last Review Date

23 Jul 2023

Expiration Date

31 Dec 2023

Estimated Time To Finish

60 Minutes


 
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Activity Description

Breast cancer genes BRCA1 and BRCA2 are tumor suppressor genes whose mutations significantly increase the likelihood of developing particular types of epithelial malignancies, namely breast and ovarian cancer. The management of patients with a BRCA1 and BRCA2 gene mutations is individualized and can include increased surveillance, chemoprevention using tamoxifen, a bilateral prophylactic oophorectomy, and/or bilateral prophylactic mastectomy. This activity describes the etiology, epidemiology, pathophysiology, screening, evaluation, and management of BRCA 1 and 2 mutations and shows the importance of the interprofessional team in educating patients about the risk of cancer and management strategy for such patients.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the pathophysiology of cancers associated with BRCA 1 and 2 mutations.
  • Outline the clinical presentation of patients with BRCA 1 and 2 mutations.
  • Explain the screening, monitoring, and treatment strategies in patients with BRCA 1 and 2 mutations.
  • Describe how an interprofessional team can collaborate to improve the diagnosis, monitoring, evaluation, and management of this condition and educate patients about the risk of cancer with BRCA 1 and 2 mutations.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Deborah Z. on 7/16/2021

Michael B. on 9/19/2021

Christine Z. on 10/7/2021

Kimberly P. on 12/2/2021

Christopher N. on 3/19/2022

Alexei K. on 5/26/2022

Shannon j. on 6/29/2022

Vincent I. on 7/1/2022

Richard H. on 7/31/2022

thank you for the presentation. it was a good format. I learned more from the teaching points after the questions than the article.

Faith G. on 8/2/2022

Deborah Z. on 8/2/2022

Phu D. on 9/15/2022

Sara M. on 9/21/2022

Tamatha J. on 10/4/2022

Nancy O. on 11/17/2022

Charles W. on 11/20/2022

Larissa k. on 11/28/2022

Thank you for the overview

Brittany S. on 12/19/2022

Clark P. on 2/8/2023

Nikotah C. on 3/2/2023

Mary Y. on 3/10/2023

Malcolm B. on 4/12/2023

Aseeb R. on 4/17/2023

Kelsey H. on 6/30/2023

Amy H. on 7/5/2023

Rebecca L. on 7/10/2023

Tracey O. on 9/11/2023

Celynne A. on 9/18/2023

Essam M. on 9/23/2023

Luba D. on 9/23/2023

Kathern R. on 10/1/2023

Jennifer T. on 10/11/2023

manojkumar b. on 10/24/2023

Sarah R. on 11/6/2023

ISLAM A. on 11/12/2023

louis v. on 11/22/2023

Susan S. on 11/26/2023

edward c. on 11/28/2023

Your questions for the quiz were excellent real world situations. Again, I'd encourage you to refer patients for genetic counseling to do a complete assessment of family history as there are often other hereditary cancer risks identified such as Lynch or polyposis syndromes. Also, genetic testing in the context of breast and ovarian cancer rarely includes only the two BRCA genes anymore as there are so many more breast and ovarian cancer genes identified now that larger gene panels are usually more appropriate.

Cherie R. on 12/13/2023

Waldo F. on 12/27/2023

Julie D. on 12/23/2023

Mary H. on 12/28/2023

MONICA D. on 12/30/2023

Kelly M. on 12/31/2023

Waldo F. on 1/3/2024

William R. on 1/21/2024

Maria D. on 1/27/2024

Great review.

Richard P. on 2/25/2024

Edward W. on 2/28/2024

Lisa R. on 3/2/2024

Mark A. on 3/16/2024

Elizabeth B. on 3/17/2024

DEAN E. on 4/3/2024

Martha D. on 4/4/2024

Dr K. on 4/14/2024

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