Factor XIII Deficiency

Overview

4.8 out of 5 (8 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Sep 2023

Last Review Date

12 Feb 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Factor XIII (FXIII) deficiency is a rare bleeding disorder that presents with symptoms spanning from delayed umbilical cord separation to intracranial hemorrhage. In its activated state, FXIII plays a pivotal role in stabilizing clots and facilitating the cross-linking of the fibrin polymer, thereby ensuring effective hemostasis. Routine coagulation assessments, such as prothrombin time and activated partial thromboplastin time, yield normal results, misleadingly indicating hemostatic normalcy. Individuals with FXIII deficiency may encounter life-threatening bleeding episodes, underscoring the importance of maintaining a heightened level of suspicion.

The acquired FXIII deficiency typically arises from factors such as hyperconsumption, hemodilution, and decreased synthesis and is more prevalent than the congenital form. In rare instances, individuals with acquired FXIII deficiency may generate autoantibodies targeting FXIII subunits. Conversely, most patients with the congenital variant display a deficiency in the A subunit. In addition, FXIII is instrumental in various physiological processes such as wound healing, phagocytosis by macrophages, tissue repair, and bacterial immobilization and clearance.

Diagnosis involves a stepwise approach, incorporating family history, personal responses to hemostatic challenges, and strategic laboratory testing. Although prophylactic and therapeutic treatment options exist, their limitations may include high cost, limited availability, infection risk, and administration-related complications. This activity discusses the etiology, evaluation, and treatment of FXIII deficiency, emphasizing the pivotal role of the interprofessional healthcare team in identifying and managing this condition.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify patients presenting with symptoms suggestive of Factor XIII deficiency through comprehensive clinical evaluation and thorough medical history assessment.

  • Implement prophylactic and therapeutic treatment strategies for patients diagnosed with Factor XIII deficiency, considering factors such as FXIII activity levels, bleeding severity, and individual patient needs, to optimize hemostasis and prevent life-threatening bleeding episodes.

  • Select alternative treatment options, such as cryoprecipitate and fresh frozen plasma, for effective hemostatic management when Factor XIII replacement products are unavailable or contraindicated.

  • Collaborate with healthcare team members to ensure comprehensive care for patients with Factor XIII deficiency by communicating effectively with them about the nature of FXIII deficiency, thereby minimizing the risk of bleeding complications and optimizing long-term outcomes.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Larry M. on 7/16/2021

Jennifer K. on 3/8/2022

Dr.Ayodhyaprasad S. on 6/24/2022

Prabhat K. on 7/8/2022

Gautam P. on 4/10/2023

Ajay P. on 6/4/2023

Dr Sruthi G. on 7/5/2023

Fatima H. on 8/3/2023

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