|Alpha 1 Antitrypsin Mutation|
Credits: 1.00 Post-Assessment Questions: 3
Release Date: 5 Oct 2020
Expiration Date: 15 Jul 2021
Last Reviewed: 15 Jul 2020
Estimated Time To Finish: 60 Minutes
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Alpha-1 antitrypsin is a protease inhibitor produced primarily in the liver. It inhibits the neutrophil elastase activity in the lung and hence can protect it from proteolytic damage. It is responsible for approximately 90% of the protection against elastolytic activity in the lower airways caused by elastase released from neutrophils. If the neutrophils' elastases are not opposed, panacinar lung tissue is damaged and increases the risk of developing chronic obstructive pulmonary disease (COPD). On the other hand, the retention and accumulation of mutated polymers in the endoplasmic reticulum of hepatocytes renders the individuals with this disease at risk of "a gain of toxic function" leading to liver disease. This activity reviews the evaluation and management of alpha-1 antitrypsin mutation and highlights the role of interprofessional team members in collaborating to provide well-coordinated care and enhance patient outcomes in the care of patients with this rare condition.
This activity has been designed to meet the educational needs of physicians.
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Authors: Ali Abdulkarim
Editors: Timothy Craig
Editors-In-Chief: Truptesh KothariSilvio de Melo Jr.Vittorio Giuliano
Chief Medical Reviewer: Donna Aileen Trovela
Nurse Planner/Reviewer/Editor: Lisa Haddad
Nurse Planner/Reviewer/Editor: Bernadette Makar
Nurse Planner/Reviewer/Editor: Dorothy Caputo
Pharmacy Planner/Reviewer/Editor: Mark Pellegrini
Physician Planner/Reviewer/Editor: Scott Dulebohn
The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.00 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.
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