Acetylcholinesterase Inhibitors Toxicity

Overview

4.8 out of 5 (61 Reviews)

Credits

1.50

Post Assessment Questions

7

Start Date

1 Jan 2021

Last Review Date

27 Apr 2023

Expiration Date

31 Dec 2023

Estimated Time To Finish

90 Minutes


 
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Activity Description

Nerve agents are some of the most deadly and easily employed chemical warfare agents. Given the global threat of terrorism, it is prudent to have a baseline knowledge of nerve agents. Some of the more recognizable nerve agents are sarin [(RS)-propan-2-yl methyphosphonofluoridate], also known as GB; soman (O-Pinacolyl methylphosphonofluoridate), also known as GD; and VX (ethyl ({2-[bis(propan-2yl)amino]ethyl}sulfanyl)(methyl)phosphinate). Initially developed in the early-to-mid 1900s from chemically similar insecticides, their volatility and potential to be weaponized was exploited during World War II. More recent examples of nerve agent use include the 1995 Tokyo subway attack with Sarin gas and the 2017 assassination of Kim Jong-Nam with VX gas. This activity reviews some of the more common nerve agents used, their associated signs and symptoms, and recommendations for management. This activity reviews the importance of the interprofessional team in diagnosing and treating patients exposed to nerve agents.

Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the signs and symptoms that a patient with acetylcholinesterase inhibitor toxicity might exhibit.
  • Identify the organ system most at risk of failing and thereby leading to mortality in patients with acetylcholinesterase inhibitor toxicity.
  • Explain important treatment considerations for patients with acetylcholinesterase inhibitor toxicity.
  • Identify the most likely setting in which the interprofessional team would be expected to deal with widespread acetylcholinesterase inhibitor toxicity. Describe how team members would communicate and collaborate to reduce the burden of the toxicity.

Disclosures

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they or their immediate family may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by CUSOM for resolution, to ensure fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

CUSOM will identify, review, and resolve all conflicts of interest that faculty, authors, activity directors, planners, managers, peer reviewers, or relevant staff disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. Disclosure information for authors, editors, planners, peer reviewers, and/or relevant staff is provided with this activity.

Continuing Education Accreditation Information

 

 

The Campbell University Jerry M. Wallace School of Osteopathic Medicine (CUSOM) is accredited by the American Osteopathic Association to provide osteopathic continuing medical education for physicians. CUSOM designates this enduring material for a maximum of 1.50 AOA Category 1 B Credits and will report CME credits commensurate with the extent of the physician's participation in the activity.

Cancellation Policy: Cancellations must be received in writing and a money back guarantee is provided if not completely satisfied.

  • StatPearls and CUSOM reserve the right to cancel any course due to unforeseen circumstances. StatPearls and CUSOM will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and CUSOM are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and CUSOM adheres to AOA Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and Campbell that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

This course is intended for osteopathic physicians who wish to earn AOA CME credit. Take this version of the course to ensure you receive appropriate credit.

 

 
 

Reviews

Deborah Z. on 1/10/2021

Sabrina C. on 2/26/2021

Mark C. on 4/17/2021

Ajith N. on 7/8/2021

Larry M. on 7/14/2021

Michelle W. on 8/19/2021

Alana H. on 8/23/2021

Sami A. on 9/16/2021

Harry A. on 9/26/2021

Thank you so much!! So valuable - I may never need it, but I'll be more likely to help now knowing this!

lee a. on 10/1/2021

Kevin C. on 11/15/2021

Karl S. on 11/17/2021

Hillary C. on 1/6/2022

Bhupendra G. on 2/12/2022

Edward M. on 3/31/2022

very concise and to the point

Alexei K. on 3/8/2022

Ejaz J. on 5/30/2022

Brian G. on 6/11/2022

Paul M. on 6/26/2022

michael o. on 7/28/2022

Kara C. on 8/9/2022

Stacey G. on 8/27/2022

Katherine S. on 9/15/2022

Scott S. on 10/14/2022

Natalie p. on 1/4/2023

Florence Y. on 1/20/2023

Larry E. on 1/28/2023

Lillian O. on 2/19/2023

Bensson S. on 3/14/2023

Sarah S. on 3/16/2023

James M. on 3/23/2023

Rita O. on 4/4/2023

Theodore K. on 4/27/2023

Iftikhar A. on 5/21/2023

edwin g. on 5/22/2023

Leon B. on 6/17/2023

Tara B. on 6/25/2023

Christopher R. on 9/15/2023

Kenneth K. on 10/4/2023

LIDIA I. on 10/7/2023

Lazo K. on 10/25/2023

robert s. on 10/27/2023

Mark S. on 11/26/2023

Stephen G. on 11/30/2023

Alexei K. on 12/9/2023

Jovelie D. on 12/25/2023

Fred H. on 12/29/2023

John P. on 12/29/2023

Hooria I. on 1/3/2024

Jameson E. on 1/18/2024

Stephen C. on 1/19/2024

edwin g. on 1/24/2024

Lazo K. on 1/30/2024

john d. on 1/31/2024

brian w. on 2/3/2024

Dana H. on 2/8/2024

Karen L. on 3/12/2024

Joseph C. on 3/19/2024

Jessica C. on 4/2/2024

Excellent

Khodaidad B. on 4/2/2024

James M. on 4/15/2024

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