Acetaminophen Toxicity

Overview

4.7 out of 5 (463 Reviews)

Credits

1.50

Post Assessment Questions

9

Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


 
Need Help?  If you have a system or content concerns, please contact support@statpearls.com

Activity Description

Acetaminophen toxicity is the second most common cause of liver transplantation worldwide and the most common cause of liver transplantation in the US. It is responsible for 56,000 emergency department visits, 2,600 hospitalizations, and 500 deaths per year in the United States. Fifty percent of these are unintentional overdoses. More than 60 million Americans consume acetaminophen on a weekly basis, and many are unaware that it is contained in combined products. This activity reviews the etiology, evaluation, and treatment of acetaminophen overdose and highlights the importance of the interprofessional team in both managing and preventing this problem.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Review the pathophysiology of acetaminophen toxicity.
  • Describe the four clinical stages of acetaminophen toxicity.
  • Identify the treatment strategies for an alert patient who presents within an hour of overdose versus a patient who presents after two hours.
  • Explain interprofessional team strategies for educating patients about acetaminophen toxicity with the goal of preventing overdose.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Deborah Z. on 1/3/2021

Chinye O. on 3/15/2021

Sabrina C. on 2/26/2021

Mark C. on 6/14/2021

Lisa R. on 7/4/2021

Victoria C. on 9/4/2021

Larry M. on 7/14/2021

Michele C. on 8/8/2021

Lisa S. on 8/13/2021

Michelle W. on 8/19/2021

Patricia M. on 8/19/2021

Janet S. on 8/25/2021

Thiago C. on 8/30/2021

Vektra C. on 8/30/2021

sharon s. on 9/6/2021

Harry A. on 9/26/2021

i really appreciated this lesson and now appreciate the teaching style of this course!! Thank you!

lee a. on 10/1/2021

Hurline S. on 10/5/2021

Valencia N. on 10/7/2021

Patrick G. on 10/14/2021

Jennifer F. on 10/31/2021

Kathleen D. on 10/31/2021

Kevin C. on 11/8/2021

nicole o. on 11/14/2021

david h. on 11/26/2021

Patricia s. on 12/2/2021

Kelly S. on 12/8/2021

Anne W. on 12/9/2021

Walter P. on 12/10/2021

Brandon C. on 12/27/2021

Laurie K. on 12/28/2021

Elaine N. on 1/14/2022

Ellen L. on 1/17/2022

sean l. on 1/20/2022

Jessica J. on 1/25/2022

Travis V. on 2/6/2022

on 2/10/2022

Maria B. on 3/6/2022

Elizabeth C. on 3/7/2022

Adriana M. on 3/10/2022

Miranda H. on 3/12/2022

Joseph T. on 3/30/2022

Emmy K. on 4/25/2022

Indumathi D. on 4/29/2022

Marlena I. on 5/10/2022

Kathryn B. on 5/13/2022

Mala B. on 5/25/2022

Ejaz J. on 5/27/2022

Stephanie V. on 5/29/2022

Bridgette H. on 6/11/2022

Christina B. on 6/18/2022

Brian T. on 7/6/2022

Taylor C. on 7/18/2022

michael o. on 7/24/2022

KIMBERLY R. on 8/8/2022

Peter M. on 8/19/2022

Santa B. on 9/16/2022

Annamma J. on 9/22/2022

SAMUEL B. on 9/27/2022

Maylin G. on 10/10/2022

Leon C. on 10/12/2022

Scott S. on 10/14/2022

Ivonne D. on 10/15/2022

Snehit P. on 10/21/2022

Leland J. on 10/17/2022

Vert good

Kenneth R. on 10/24/2022

Himeshkumar P. on 10/30/2022

Lindsey M. on 11/19/2022

Dr Narinder S. on 11/25/2022

Rosemary V. on 11/28/2022

Scott R. on 11/29/2022

Christine G. on 12/3/2022

Adi F. on 12/6/2022

reno l. on 12/8/2022

Mary C. on 12/10/2022

long h. on 12/9/2022

Claudia C. on 12/11/2022

Brian C. on 12/22/2022

Emily B. on 12/29/2022

Fredrick J. on 12/31/2022

Natalie p. on 1/4/2023

Kimberly H. on 1/9/2023

Florence Y. on 1/13/2023

jon d. on 1/19/2023

Laura p. on 2/5/2023

I would add the Rumack-Mathew Nomogram and explain based on it where low risk, high risk and in between means

Lillian O. on 2/12/2023

Marc D. on 2/15/2023

Deborah B. on 3/4/2023

Cruz s. on 3/6/2023

Noel J. on 3/8/2023

John C. on 3/11/2023

Theodore D. on 3/12/2023

Raven H. on 3/15/2023

Murali M. on 3/18/2023

jennifer m. on 3/24/2023

Alexander D. on 3/27/2023

Susan h. on 4/7/2023

Maili N. on 4/9/2023

Mary C. on 4/26/2023

Austin T. on 4/26/2023

Svetlana T. on 4/28/2023

Karim M. on 5/2/2023

Brianna P. on 5/2/2023

Brendalla G. on 5/3/2023

Mohammed J. on 5/14/2023

Michelle K. on 5/14/2023

Theodore K. on 5/17/2023

Haleigh F. on 6/2/2023

Mary M. on 5/22/2023

Amie B. on 8/23/2023

Lily L. on 5/24/2023

John G. on 5/25/2023

Nicole M. on 5/28/2023

Bryan B. on 6/1/2023

Laxmi S. on 6/4/2023

Mohamed E. on 6/21/2023

Andrew M. on 6/5/2023

Iftikhar A. on 6/9/2023

Ann K. on 6/12/2023

RICHARD P. on 6/13/2023

Gregory P. on 6/16/2023

Aditya S. on 6/22/2023

Breena A. on 6/24/2023

Patricia R. on 6/27/2023

Gary A. on 7/1/2023

Michele N. on 7/7/2023

Catherine R. on 7/9/2023

Lisa R. on 7/12/2023

Qefli N. on 7/15/2023

Patricia G. on 7/15/2023

Anne C. on 7/18/2023

Miguel D. on 7/18/2023

Gregory S. on 7/25/2023

Katherine L. on 7/27/2023

Fidel H. on 7/30/2023

Haiyan Z. on 7/31/2023

Dat N. on 7/31/2023

Grace A. on 8/8/2023

Cathy G. on 8/8/2023

Wendy L. on 8/9/2023

Samar f. on 8/15/2023

Nicholas T. on 8/22/2023

Mark S. on 8/29/2023

Ali S. on 8/31/2023

Shearin H. on 9/1/2023

Emily V. on 9/2/2023

Nathaniel S. on 9/5/2023

DONG D. on 9/5/2023

Christina D. on 9/6/2023

Christina B. on 9/6/2023

shri v. on 9/9/2023

ROBERT M. on 9/9/2023

Chris C. on 9/10/2023

Christopher L. on 9/12/2023

Jose D. on 9/14/2023

Xasan W. on 9/14/2023

David G. on 9/14/2023

Nicole F. on 9/15/2023

Christopher R. on 9/15/2023

Leslie A. on 9/16/2023

Jonathan Z. on 9/18/2023

Julia D. on 9/19/2023

Eric T. on 9/23/2023

mary m. on 9/23/2023

Stephanie R. on 9/25/2023

gerard b. on 9/26/2023

Melissa B. on 9/29/2023

Melody M. on 9/30/2023

Rodrigo C. on 10/1/2023

Humayun Z. on 10/1/2023

Byron L. on 10/2/2023

Karen K. on 10/3/2023

Sarah R. on 10/4/2023

rajab i. on 10/4/2023

Rosemary V. on 10/9/2023

Sendil K. on 10/12/2023

Adina S. on 10/15/2023

Ralph C. on 10/17/2023

Brian G. on 10/19/2023

Karamo C. on 10/19/2023

Jami P. on 10/20/2023

John M. on 10/20/2023

DELALI A. on 10/20/2023

Jordan L. on 10/22/2023

Andrew W. on 10/23/2023

Mark G. on 10/23/2023

Karen G. on 10/24/2023

MICHELLE B. on 10/24/2023

Kayci H. on 10/24/2023

julie j. on 10/25/2023

Lazo K. on 10/25/2023

Nyomi W. on 10/26/2023

281 on 10/26/2023

Andrew L. on 10/30/2023

Frederick S. on 10/30/2023

Mary k. on 10/31/2023

sharon o. on 10/31/2023

Juan H. on 11/1/2023

Christopher E. on 11/2/2023

Helen d. on 11/4/2023

Srijna N. on 11/6/2023

Ann c. on 11/6/2023

Suzana S. on 11/6/2023

Joanne Z. on 11/7/2023

David V. on 11/7/2023

John H. on 11/9/2023

Chad S. on 11/11/2023

ravinder w. on 11/12/2023

ISLAM A. on 11/12/2023

Darren S. on 11/14/2023

Katherine H. on 11/15/2023

Robert R. on 11/15/2023

Andrew C. on 11/15/2023

Anne S. on 11/15/2023

Edward F. on 11/16/2023

Ruchira V. on 11/16/2023

Christopher K. on 11/18/2023

Nizar N. on 11/19/2023

Carolyn B. on 11/19/2023

William L. on 11/19/2023

prabhakar r. on 11/20/2023

Kevin B. on 11/21/2023

JAY J. on 11/22/2023

Brian M. on 11/22/2023

Robin M. on 11/23/2023

Shandal E. on 11/24/2023

Marcus H. on 11/25/2023

Tarik H. on 11/25/2023

Manish S. on 11/25/2023

Jennifer S. on 12/3/2023

Naga Dharshan D. on 11/26/2023

THAN A. on 11/26/2023

SILVIO M. on 11/26/2023

Frank C. on 11/26/2023

Sanjay T. on 11/26/2023

Mark S. on 11/26/2023

Alexei K. on 11/27/2023

Wei-hsung L. on 11/26/2023

Ann C. on 11/27/2023

Kathryn g. on 11/27/2023

Steven G. on 11/27/2023

Scott O. on 11/28/2023

harold m. on 11/28/2023

Lynda N. on 11/29/2023

kristi f. on 11/29/2023

Michelle R. on 11/30/2023

Robert P. on 11/30/2023

Denise W. on 12/1/2023

Nestor C. on 11/30/2023

Erin M. on 12/1/2023

Alaina L. on 12/1/2023

Carolyn B. on 12/1/2023

Ephrem Hector P. on 12/2/2023

Daniel A. on 12/3/2023

Nanette M. on 12/3/2023

unnikrishnan t. on 12/3/2023

Katarina V. on 12/4/2023

Laura D. on 12/4/2023

Paige M. on 12/4/2023

Robert H. on 12/4/2023

Antonio H. on 12/4/2023

Craig W. on 12/6/2023

Kaman C. on 12/7/2023

Cathryn C. on 12/7/2023

Fabian L. on 12/9/2023

Rahul P. on 12/10/2023

Mark M. on 12/11/2023

Nafea Z. on 12/11/2023

Hawabu S. on 12/12/2023

sean l. on 12/12/2023

Kamran T. on 12/13/2023

Kathleen C. on 12/13/2023

Hamid B. on 12/13/2023

Robert H. on 12/14/2023

Mandy H. on 12/14/2023

Adrian d. on 12/16/2023

Bruce T. on 12/17/2023

none

osei b. on 12/17/2023

Margaret D. on 12/17/2023

Thomas S. on 12/17/2023

mohamad a. on 12/18/2023

NATHAN M. on 12/18/2023

DILIPKUMAR P. on 12/19/2023

Aviva Z. on 12/19/2023

Ranjana S. on 12/19/2023

William E. on 12/19/2023

Addison Z. on 12/19/2023

Samantha B. on 12/20/2023

Wayne S. on 12/20/2023

Cynthia W. on 12/22/2023

Gregorio J. on 12/21/2023

Jocelyn R. on 12/21/2023

Jane R. on 12/22/2023

Kimberly O. on 12/22/2023

Park C. on 12/22/2023

Cynthia O. on 12/23/2023

Becky C. on 12/23/2023

vasudha d. on 12/23/2023

Susan W. on 12/24/2023

Barbara S. on 12/24/2023

Son L. on 12/25/2023

Ronny A. on 12/25/2023

ARVIND B. on 12/25/2023

Thank you!

Michelle W. on 12/25/2023

JAMES L. on 12/26/2023

Jonathan L. on 12/28/2023

Tim P. on 12/26/2023

Hita S. on 12/27/2023

Jonathan B. on 12/27/2023

Antonio V. on 12/27/2023

Aurelio T. on 12/27/2023

John T. on 12/28/2023

Adrian G. on 12/28/2023

sandra r. on 12/28/2023

Kathleen . on 12/29/2023

David B. on 12/29/2023

David C. on 12/30/2023

Steven L. on 12/29/2023

Samuel M. on 12/29/2023

Adel H. on 12/29/2023

sundy h. on 12/30/2023

Dr. Amer J. on 12/30/2023

Guillermo M. on 12/30/2023

Maria R. on 12/30/2023

Pamela J. on 12/30/2023

Christopher B. on 12/30/2023

Elena V. on 12/30/2023

Elizabeth G. on 12/30/2023

Illuri r. on 12/30/2023

J B. on 12/31/2023

Joseph Y. on 12/31/2023

Melany H. on 12/31/2023

TRINA S. on 12/31/2023

Paul P. on 12/31/2023

Di Y. on 1/1/2024

cynthia W. on 1/1/2024

thank you

Opeyemi B. on 1/1/2024

Trent p. on 1/1/2024

Shakib S. on 1/1/2024

Chameng V. on 1/3/2024

Hooria I. on 1/3/2024

Richard M. on 1/4/2024

Amy B. on 1/5/2024

Patricia S. on 1/5/2024

Nancy S. on 1/6/2024

Zhengyi C. on 1/7/2024

terry k. on 1/13/2024

Ivel D. on 1/9/2024

Karl O. on 1/9/2024

Kathryn H. on 1/10/2024

William F. on 1/17/2024

Trishala A. on 1/19/2024

Stephen C. on 1/19/2024

Scott S. on 1/19/2024

Colin M. on 1/19/2024

David F. on 1/20/2024

Christin H. on 1/20/2024

hiba e. on 1/20/2024

Mary M. on 1/20/2024

Sharon T. on 1/20/2024

Cong N. on 1/21/2024

Jonathan L. on 1/21/2024

okeowo I. on 1/21/2024

Kenneth V. on 1/21/2024

Katie O. on 1/22/2024

Cathryn C. on 1/22/2024

Lisa C. on 1/22/2024

Muhammad K. on 1/23/2024

Ambreen S. on 1/25/2024

john d. on 1/26/2024

Kaman C. on 1/27/2024

Lazo K. on 1/27/2024

Stephanie E. on 1/27/2024

hans r. on 1/27/2024

JAMES P. on 1/28/2024

Elizabeth D. on 1/28/2024

Adrian G. on 1/29/2024

Cynthia V. on 1/30/2024

brian c. on 1/30/2024

Idrissa i. on 1/30/2024

Sai Sunil kishore M. on 1/31/2024

David S. on 2/1/2024

michael l. on 2/2/2024

Ernest S. on 2/3/2024

brian w. on 2/4/2024

JOSES Y. on 2/4/2024

Beatrice O. on 2/4/2024

Luis T. on 2/14/2024

Yongmei J. on 2/15/2024

Chris R. on 2/15/2024

Meredith G. on 2/21/2024

Sarah U. on 2/20/2024

PATRICK S. on 2/17/2024

Belinda L. on 2/17/2024

ISLAM A. on 2/18/2024

Makeswaran S. on 3/14/2024

Jonathan A. on 2/19/2024

Truclinh N. on 2/20/2024

Katayun S. on 2/20/2024

TRINA S. on 2/21/2024

Bozena B. on 2/22/2024

ROXANNA R. on 2/22/2024

excellent tutorial

Karol R. on 2/23/2024

Jill L. on 2/23/2024

Lisa D. on 2/24/2024

Said a. on 2/24/2024

PAUL W. on 2/24/2024

Klaus M. on 2/24/2024

Warren S. on 2/25/2024

henry c. on 2/26/2024

Syed B. on 2/27/2024

Lisa W. on 2/27/2024

Doug T. on 2/28/2024

Maria M. on 2/29/2024

Eric F. on 2/29/2024

Abdul K. on 3/2/2024

Olusanya R. on 3/2/2024

Melissa A. on 3/3/2024

sumalatha s. on 3/6/2024

Lauren H. on 3/7/2024

Hugh B. on 3/8/2024

Caleigh S. on 3/9/2024

Anton v. on 3/10/2024

Christopher K. on 3/10/2024

Sonia D. on 3/11/2024

SAJJAD M. on 3/11/2024

Laura P. on 3/11/2024

Kelly M. on 3/11/2024

Alexandra M. on 3/13/2024

Mark G. on 3/13/2024

James R. on 3/18/2024

Andrew F. on 3/18/2024

DANIELA j. on 3/18/2024

Ping-Yi L. on 3/19/2024

parthiv r. on 3/18/2024

JEANNETTE A. on 3/24/2024

Keep up the good work

Thomas S. on 3/24/2024

jesse b. on 3/26/2024

Prathibha P. on 3/27/2024

Luis R. on 3/28/2024

Zahid Q. on 3/28/2024

Mohammad I. on 3/29/2024

John B. on 3/29/2024

larry m. on 3/29/2024

Suma A. on 4/1/2024

Kristine R. on 4/2/2024

Excellent

Khodaidad B. on 4/2/2024

Nancy A. on 4/2/2024

Hui S. on 4/2/2024

Melissa D. on 4/3/2024

Nafea Z. on 4/3/2024

subodh m. on 4/14/2024

Mohammad G. on 4/4/2024

Tiffany M. on 4/5/2024

Fernando M. on 4/6/2024

Jayshree D. on 4/6/2024

Kevin M. on 4/8/2024

cyrus i. on 4/9/2024

Eskinder A. on 4/11/2024

Lesly P. on 4/14/2024

jemini i. on 4/14/2024

musib g. on 4/15/2024

Robert S. on 4/15/2024

Unlimited Physician CME

Stay up to date on the latest medical knowledge with 6673 CME activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7923.5 hours of CME.

Learn About Lifetime CME

Single Activity

Take this single activity

$73.50 1 activity

6 Month Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$399 per half year per user

1 Year Unlimited Physician CME

Access to all the Unlimited Physician CME activities in all specialties.

$599 per 1 year per user