BRCA1 and BRCA2 Mutations

Overview

4.7 out of 5 (55 Reviews)

Credits

1.00

Post Assessment Questions

8

Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Breast cancer genes BRCA1 and BRCA2 are tumor suppressor genes whose mutations significantly increase the likelihood of developing particular types of epithelial malignancies, namely breast and ovarian cancer. The management of patients with a BRCA1 and BRCA2 gene mutations is individualized and can include increased surveillance, chemoprevention using tamoxifen, a bilateral prophylactic oophorectomy, and/or bilateral prophylactic mastectomy. This activity describes the etiology, epidemiology, pathophysiology, screening, evaluation, and management of BRCA 1 and 2 mutations and shows the importance of the interprofessional team in educating patients about the risk of cancer and management strategy for such patients.

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the pathophysiology of cancers associated with BRCA 1 and 2 mutations.
  • Outline the clinical presentation of patients with BRCA 1 and 2 mutations.
  • Explain the screening, monitoring, and treatment strategies in patients with BRCA 1 and 2 mutations.
  • Describe how an interprofessional team can collaborate to improve the diagnosis, monitoring, evaluation, and management of this condition and educate patients about the risk of cancer with BRCA 1 and 2 mutations.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

American Board of Surgery: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Deborah Z. on 7/16/2021

Michael B. on 9/19/2021

Christine Z. on 10/7/2021

Kimberly P. on 12/2/2021

Christopher N. on 3/19/2022

Alexei K. on 5/26/2022

Shannon j. on 6/29/2022

Vincent I. on 7/1/2022

Richard H. on 7/31/2022

thank you for the presentation. it was a good format. I learned more from the teaching points after the questions than the article.

Faith G. on 8/2/2022

Deborah Z. on 8/2/2022

Phu D. on 9/15/2022

Sara M. on 9/21/2022

Tamatha J. on 10/4/2022

Nancy O. on 11/17/2022

Charles W. on 11/20/2022

Larissa k. on 11/28/2022

Thank you for the overview

Brittany S. on 12/19/2022

Clark P. on 2/8/2023

Nikotah C. on 3/2/2023

Mary Y. on 3/10/2023

Malcolm B. on 4/12/2023

Aseeb R. on 4/17/2023

Kelsey H. on 6/30/2023

Amy H. on 7/5/2023

Rebecca L. on 7/10/2023

Tracey O. on 9/11/2023

Celynne A. on 9/18/2023

Essam M. on 9/23/2023

Luba D. on 9/23/2023

Kathern R. on 10/1/2023

Jennifer T. on 10/11/2023

manojkumar b. on 10/24/2023

Sarah R. on 11/6/2023

ISLAM A. on 11/12/2023

louis v. on 11/22/2023

Susan S. on 11/26/2023

edward c. on 11/28/2023

Your questions for the quiz were excellent real world situations. Again, I'd encourage you to refer patients for genetic counseling to do a complete assessment of family history as there are often other hereditary cancer risks identified such as Lynch or polyposis syndromes. Also, genetic testing in the context of breast and ovarian cancer rarely includes only the two BRCA genes anymore as there are so many more breast and ovarian cancer genes identified now that larger gene panels are usually more appropriate.

Cherie R. on 12/13/2023

Waldo F. on 12/27/2023

Julie D. on 12/23/2023

Mary H. on 12/28/2023

MONICA D. on 12/30/2023

Kelly M. on 12/31/2023

Waldo F. on 1/3/2024

William R. on 1/21/2024

Maria D. on 1/27/2024

Great review.

Richard P. on 2/25/2024

Edward W. on 2/28/2024

Lisa R. on 3/2/2024

Mark A. on 3/16/2024

Elizabeth B. on 3/17/2024

DEAN E. on 4/3/2024

Martha D. on 4/4/2024

Dr K. on 4/14/2024

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