4.6 out of 5 (109 Reviews)



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Expiration Date

31 Dec 2023

Last Reviewed

1 Jan 2021

Estimated Time To Finish

75 Minutes

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Activity Description

Many diseases and conditions list pain as a component of their presentation; as a result, pain management is of great importance to clinicians and patients alike. Acetaminophen (APAP - also known as paracetamol in many countries) is a non-opioid analgesic and antipyretic agent used to treat pain and fever. It is used as a single agent for mild to moderate pain and combined with an opioid analgesic for severe pain. This activity outlines the use, dosing, indications, contraindications, toxicity, and toxicity management of acetaminophen and highlights the role of the interprofessional team in caring for patients who take acetaminophen.

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Target Audience

This activity has been designed to meet the educational needs of physicians.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the indications for acetaminophen use.
  • Describe the potential toxicity of acetaminophen.
  • Explain how to monitor for acetaminophen toxicity.
  • Review interprofessional team strategies for improving care coordination so that acetaminophen therapy is optimized as a useful tool to improve patient outcomes in pain management.

Author(s) / Contributors Disclosure of Conflicts of Interest

Each author, editor, faculty and planning committee member have completed a disclosure form indicating that neither they nor their spouse/partner has a financial interest/arrangement or affiliation that could be perceived as a real or apparent conflict of interest related to the content of this activity.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Quillen College of Medicine, East Tennessee State University, and StatPearls, LLC. The Quillen College of Medicine, East Tennessee State University is accredited by the ACCME to provide continuing medical education for physicians.

Quillen College of Medicine, East Tennessee State University designates this activity for a maximum of 1.25 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity is reported to the following Maintenance of Certification (MOC) boards:
American Board of Anesthesiology
  • Critical Care Medicine
American Board of Internal Medicine
  • Adolescent Medicine
  • Critical Care Medicine
  • Hospice and Palliative Medicine
  • Hospital Medicine
  • Internal Medicine
  • Gastroenterology
American Board of Pathology
  • Chemical Pathology
  • GI (incl. Liver, Pancreas, Bilary)
American Board of Pediatrics
  • Adolescent Medicine
  • Medical Toxicology
  • Pediatric Gastroenterology

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearls and ETSU reserve the right to cancel any course due to unforeseen circumstances. StatPearls and ETSU will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and ETSU are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives, and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation survey. 
  7. Obtain a certificate.

StatPearls and ETSU adhere to ACCME Standards regarding commercial support of continuing medical education. It is the policy of StatPearls and ETSU that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided at this CME/CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

  • If you need help with the system or have a question about content, please contact
  • If you have a question about the ETSU CME providership, please contact


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


    Dr Martin r. on 12/6/2020

    Deborah Z. on 1/10/2021

    good review

    NASAR S. on 2/26/2021

    Guillermina H. on 4/21/2021

    Sandeep S. on 5/9/2021

    Kayleigh S. on 6/10/2021

    Michele C. on 8/8/2021

    Alana H. on 8/23/2021

    JANE P. on 8/23/2021

    edwina w. on 8/29/2021

    B P. on 9/2/2021

    Marquita M. on 9/6/2021

    Elizabeth M. on 9/8/2021

    Ashley T. on 9/11/2021

    Tiffany M. on 9/12/2021

    Therese M. on 9/15/2021

    Casey B. on 9/17/2021

    Urvashi K. on 9/18/2021

    Christine F. on 9/23/2021

    Janet L. on 9/24/2021

    Harry A. on 9/26/2021

    Samuel k. on 9/27/2021

    Nancy N. on 9/28/2021

    Erika A. on 9/30/2021

    I would've like more info on IV tylenol for pain

    lee a. on 9/30/2021

    Timothy R. on 9/30/2021

    Michael Y. on 10/1/2021

    Hurline S. on 10/5/2021

    Patrick G. on 10/14/2021

    mikaela v. on 10/17/2021

    Adam T. on 10/17/2021

    Thomas P. on 10/25/2021

    Kimberly A. on 10/29/2021

    Anne H. on 10/31/2021

    Kathleen D. on 10/31/2021

    sarah s. on 11/1/2021

    Mary C. on 11/10/2021

    Stephanie K. on 11/16/2021

    Sarah A. on 11/19/2021

    Kevin L. on 11/21/2021

    Kenneth W. on 11/27/2021

    Kavishwar w. on 11/27/2021

    Eddie S. on 11/28/2021

    Thank you.

    Douglas T. on 12/5/2021

    Kelly S. on 12/6/2021

    Chris C. on 12/8/2021

    Hope H. on 12/17/2021

    Terri C. on 12/22/2021

    Eric Y. on 12/22/2021

    Joseph B. on 12/27/2021

    SANDRA R. on 12/27/2021

    Paige L. on 12/29/2021

    Neeraj H. on 12/30/2021


    SREEDEVI Y. on 12/31/2021

    Catilyn D. on 1/2/2022

    Great site for Nurse Practitioners!

    Irvin C. on 1/11/2022

    Elaine N. on 1/14/2022

    Dylan A. on 1/16/2022

    Ellen L. on 1/19/2022

    sanaz l. on 1/20/2022

    Laura P. on 1/27/2022

    Michael D. on 1/29/2022

    Kim N. on 2/7/2022

    Julie P. on 2/24/2022

    Miranda H. on 3/13/2022

    Robin A. on 3/22/2022

    Indumathi D. on 4/12/2022

    Abbey P. on 4/12/2022

    Emmy K. on 4/22/2022

    Stephanie H. on 4/20/2022

    Laura P. on 4/25/2022

    Michele D. on 5/1/2022

    Janet M. on 5/3/2022

    Esther B. on 5/11/2022

    cyvada s. on 5/12/2022

    Megan M. on 5/17/2022

    Ejaz J. on 5/25/2022

    MARC M. on 5/27/2022

    Peter M. on 5/27/2022

    Amy R. on 5/28/2022

    Pamela D. on 6/1/2022

    Stephen A. on 6/1/2022

    Rodabeh M. on 6/4/2022

    Stephanie C. on 6/5/2022

    Kerrey T. on 6/7/2022

    Bridgette H. on 6/11/2022

    Dawn E. on 6/12/2022

    Emily V. on 6/13/2022

    Krista M. on 6/14/2022

    Victoria P. on 6/18/2022

    Nathan S. on 6/18/2022

    Jennifer L. on 6/22/2022

    AC R. on 6/24/2022

    Grace N. on 6/26/2022

    Jennifer L. on 7/4/2022

    Ashley M. on 7/15/2022

    Shannon j. on 7/18/2022

    Kimberly T. on 7/26/2022

    Brittany T. on 8/1/2022

    Evaluation was longer than expected.

    Kelly A. on 8/4/2022

    Steve R. on 8/6/2022

    Richard M. on 8/10/2022

    brittany l. on 8/21/2022

    isabel c. on 8/21/2022

    Michael A. on 8/26/2022

    SHIRLEY A. on 8/29/2022

    siminibe m. on 9/13/2022

    Spencer A. on 9/14/2022

    Nicole G. on 9/17/2022

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