Donepezil

Overview

4.7 out of 5 (41 Reviews)

Credits

1.50

Post Assessment Questions

10

Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


 
Need Help?  If you have a system or content concerns, please contact support@statpearls.com

Activity Description

Donepezil hydrochloride, a piperidine derivative, is a centrally acting, rapid, and reversible acetylcholinesterase inhibitor primarily utilized for treating Alzheimer disease. Acetylcholinesterase is an enzyme that breaks down acetylcholine after its release from the presynapse. By binding reversibly to acetylcholinesterase, donepezil inhibits acetylcholine hydrolysis, thereby increasing acetylcholine availability at the synapses and enhancing cholinergic transmission. The U.S. Food and Drug Administration (FDA) approved the drug for the treatment of dementia in mild, moderate, and severe Alzheimer disease. Although there is currently no evidence to suggest that donepezil can alter the progression of the disease, it has shown efficacy in alleviating specific symptoms by improving cognition and/or behavior in affected individuals. In addition to its FDA-approved use in Alzheimer disease, donepezil has various off-label indications. This activity emphasizes the mechanism of action, adverse event profile, pharmacokinetics, monitoring requirements, and relevant drug interactions of donepezil. This information is crucial for interprofessional team members involved in treating patients with dementia associated with Alzheimer disease.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify appropriate candidates for donepezil therapy based on clinical criteria and diagnostic guidelines for Alzheimer disease.
  • Screen patients for potential contraindications, comorbidities, or risk factors associated with donepezil, which may influence the use of the drug in Alzheimer treatment.
  • Assess the treatment efficacy and tolerability of donepezil in patients with Alzheimer disease through regular cognitive and behavioral evaluations.
  • Coordinate ongoing monitoring and follow-up care among healthcare professionals, caregivers, and support systems to address the potential issues and complex needs of patients receiving donepezil for Alzheimer disease management.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Physicians and Physician Associates: StatPearls, LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 Credit(s)TM. Physicians and PAs should only claim credit commensurate with the extent of their participation in the activity.

American Board of Anesthesiology: This activity contributes to the CME component of the American Board of Anesthesiology’s redesigned Maintenance of Certification in AnesthesiologyTM (MOCA®) program, known as MOCA 2.0®. Please consult the ABA website, www.theABA.org, for a list of all MOCA 2.0 requirements.

American Board of Internal Medicine: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology: Successful completion of this Continuing Certification activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Lifelong Learning (CME) credits in the American Board of Pathology’s Continuing Certification Program.

American Board of Pediatrics: Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 1.50 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

Royal College of Physicians and Surgeons of Canada: Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Thomas P. on 3/20/2021

devin n. on 2/26/2022

Janet M. on 5/3/2022

Angjelin S. on 5/3/2022

Carolyn G. on 5/22/2022

Kimberly G. on 6/21/2022

Soheyla M. on 7/8/2022

Natalia M. on 8/21/2022

victoria s. on 8/23/2022

Nicole F. on 8/29/2022

Nicole G. on 9/6/2022

IRIS O. on 9/25/2022

Darra H. on 1/6/2023

Abrah N. on 1/13/2023

MARGARONE M. on 1/25/2023

jubril o. on 1/24/2023

Wayne S. on 1/29/2023

JOSE P. on 2/7/2023

Dominika S. on 2/8/2023

amy s. on 2/16/2023

Tammy S. on 3/28/2023

Jennifer P. on 4/15/2023

Arash S. on 4/22/2023

Lily L. on 4/26/2023

James N. on 5/31/2023

Kimberley R. on 6/5/2023

Hiroko P. on 6/7/2023

Peter M. on 6/13/2023

Amy G. on 8/1/2023

Yan L. on 9/28/2023

Theresa M. on 10/5/2023

Daniel S. on 10/6/2023

Sarah B. on 10/30/2023

Nanette M. on 12/3/2023

Lisa S. on 12/7/2023

alex b. on 1/21/2024

Joseph S. on 2/11/2024

Jibril Y. on 2/19/2024

Vincent B. on 3/18/2024

It would be helpful if this activity also included the co-treatment options with other medications for dementia to present a more well-rounded picture of treatment and titration options.

Nellyda A. on 4/8/2024

ALI O. on 4/22/2024

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