Overview

4.7 out of 5 (15 Reviews)

Credits

1.00

Post Assessment Questions

5

Start Date

1 Sep 2023

Last Review Date

14 Feb 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
Need Help?  If you have a system or content concerns, please contact support@statpearls.com

Activity Description

Doxepin belongs to the class of tricyclic antidepressant medications approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder, anxiety, and insomnia, as well as for managing skin pruritus. Doxepin functions by increasing the concentration of the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) and norepinephrine (NE) in the brain. This mechanism extends the availability of the neurotransmitters (5-HT and NE) within the synaptic cleft and enhances their neurotransmission by preventing their reuptake into the presynaptic terminal.

Doxepin also displays antagonistic effects in the central nervous system by blocking receptors such as histamine (H1), α1 adrenergic, and muscarinic. Furthermore, doxepin inhibits sodium and potassium channels in cardiomyocytes, thereby broadening the drug's indications profile. This activity provides an overview of doxepin's indications, administration, mechanism of action, adverse effects, contraindications, and toxicity to improve the competence of the interprofessional healthcare team in administering the drug safely and effectively. This activity highlights the importance of utilizing a team-based approach to treat patients with major depressive disorder. Collaborative care involving primary care, psychiatry, and other related disciplines would optimize patient outcomes.


UAN: JA4008338-0000-23-5440-H01-P

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the appropriate indications for prescribing doxepin, including its approved uses in the treatment of major depressive disorder, anxiety disorders, and insomnia.

  • Implement appropriate dosing strategies for initiating doxepin therapy, considering the recommended titration schedule and the need for dosage adjustments based on individual patient response and tolerability.

  • Select the most appropriate formulation, dose, and dosing schedule of doxepin based on individual patient factors, preferences, and treatment goals.

  • Collaborate with interdisciplinary healthcare team members to provide comprehensive care for patients receiving doxepin therapy, addressing both psychiatric and psychosocial needs.

Pharmacy Activity Type:
Disease/Drug Therapy Related


Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Pharmacists: StatPearls, LLC designates this activity for a maximum of 1.00 ACPE credit(s). (UAN: JA4008338-0000-23-5440-H01-P ). Pharmacists should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

ROY A. on 10/19/2021

Christopher N. on 6/1/2022

David G. on 8/1/2022

Marlen L. on 10/18/2022

Alyssa C. on 1/22/2023

Latoya R. on 1/29/2023

Shirley A. on 4/13/2023

Susan M. on 4/21/2023

Lily L. on 4/26/2023

Michael P. on 6/5/2023

Kathleen P. on 6/21/2023

Christa R. on 9/6/2023

Margaret D. on 1/2/2024

Jibril Y. on 2/20/2024

Margaret M. on 3/28/2024

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